Pierre Bruhns

The B-cell Interest Group (BIG) is a think-tank of immunologists focusing their research activities on diverse aspects of B lymphocytes and their effector molecules, antibodies. It gathers experts from the Institut Pasteur, the INEM […]

Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]

Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]

 In this project we propose to combine ultrahigh-throughput screening of primary B cells using droplet based microfluidics with next-generation sequencing to profile entire B cell antibody repertoires. This process will enable highly-efficient and rapid […]

Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.

Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice: establishment in these mice of clinically pertinent models of allergic and autoimmune (inflammatory) diseases. Refer to European Research Council Grant “MyeloSHOCK for […]

 Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction