Principal Investigator – Head of research unit Director of Research (DR1) @ INSERM & @ Institut Pasteur 2001: PhD in Immunology 2010: HDR diploma (Authorization to mentor PhD students) Publons / ResearcherID: F-5567-2013
High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)
Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples
Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]
DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery
In this project we propose to combine ultrahigh-throughput screening of primary B cells using droplet based microfluidics with next-generation sequencing to profile entire B cell antibody repertoires. This process will enable highly-efficient and rapid […]
Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Clinical and pathological consequences of human anti-drug antibodies (NASA study)
Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
Developing novel models of disease and vaccination in Ab- and FcR-humanized mice
Developing novel models of disease and vaccination in Ab- and FcR-humanized mice: establishment in these mice of clinically pertinent models of allergic and autoimmune (inflammatory) diseases. Refer to European Research Council Grant “MyeloSHOCK for […]
Antibody-based anti-tumor immunotherapy
Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction
METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS
Lactobacillus compositions, especially those based on L. casei, and methods for the prevention and treatment of diseases or disorders involving or mediated by mast cells, such as anaphylaxis, allergy, autoimmune and inflammatory disorders including […]
USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK
The present invention relates to the prevention and/or treatment of arthritic, inflammatory and/or allergic reactions as well as thrombocytopenia, by blocking the human receptors FcyRI and FcyRIIA. It is disclosed a mouse monoclonal antibody […]
2019An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence, Nat. Commun. 10, 5031..
2019An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis, Sci Transl Med. 2019 Jul 10: Vol. 11, Issue 500, eaat1479 DOI: 10.1126/scitranslmed.aat1479 .
2018Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis., Sci Immunol. 2018 Apr 13;3(22). .
2017Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions., Br J Anaesth. 2017 Nov 1;119(5):908-917.
2017Single-cell deep phenotyping of IgG-secreting cells for high-resolution immune monitoring, Nat. Biotechnol. 2017 Oct;35(10):977-982.
2017Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide, J Exp Med, 2017; in press.
2016In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models., J Autoimmun. 2016 Oct 10. pii: S0896-8411(16)30183-4..
2016Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice., J Allergy Clin Immunol. 2016 Aug 24..
2016IgG subclasses determine pathways of anaphylaxis in mice, J. Allergy Clin. Immunol. 2017 01;139(1):269-280.e7.
2015Mouse and human FcR effector functions., Immunol Rev. 2015 Nov;268(1):25-51..
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