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© Matteo Bonazzi, Edith Gouin
Observation en immunofluorescence d'une cellule infectée par Listeria monocytogenes. En bleu: marquage des protéines de surface de Listeria qui permet de visualiser les bactéries. En rouge et vert: marquage de l'actine, une protéine qui forme le cytosquelette des cellules. Les Listeria utilisent l'actine cellulaire pour former des "comêtes" et se déplacer à l'intérieur des cellules qu'elles infectent. Cell infected by Listeria monocytogenes. The surface proteins (in blue) of Listeria enable us to view the bacteria. Actin, a constituent protein of cells, is shown in red and green.

Projects

Project
Ongoing
3 Members

High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)

Pierre Lafaye (PI)
Project
Ongoing
15 Members

Microfluidics@Pasteur

Samy Gobaa (PI)

Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Project
Ongoing
6 Members

ERC-2013-CoG – 616050_MyeloSHOCK – Role of myeloid cells, their mediators and their antibody receptors in allergic shock (anaphylaxis) using humanized mouse models and clinical samples

Pierre Bruhns (PI)

Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment. Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific […]
Project
Ongoing
5 Members

DROPmAbs – Deep-mining of antibody repertoires using droplet-based microfluidics combined with barcoded deep sequencing for diagnostics and therapeutic antibody discovery

Pierre Bruhns (PI)

 In this project we propose to combine ultrahigh-throughput screening of primary B cells using droplet based microfluidics with next-generation sequencing to profile entire B cell antibody repertoires. This process will enable highly-efficient and rapid […]
Project
Ongoing
5 Members

Role of platelets and their interactions in allergic diseases

Friederike Jönsson (PI)

Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Project
Ongoing
3 Members

Clinical and pathological consequences of human anti-drug antibodies (NASA study)

Pierre Bruhns (PI)

Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
Project
Ongoing
2 Members

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice

Pierre Bruhns (PI)

Developing novel models of disease and vaccination in Ab- and FcR-humanized mice: establishment in these mice of clinically pertinent models of allergic and autoimmune (inflammatory) diseases. Refer to European Research Council Grant “MyeloSHOCK for […]
Project
Ongoing
3 Members

Antibody-based anti-tumor immunotherapy

Pierre Bruhns (PI)

 Antibody-based anti-tumor immunotherapy that aims at identifying the human FcγRs involved in melanoma and/or breast cancer immunotherapy, and at identifying the effector population(s) responsible for tumor destruction

Patents

METHODS FOR INHIBITING MAST CELL ACTIVATION AND TREATING MAST CELL-DEPENDENT INFLAMMATORY DISEASES AND DISORDERS USING LACTOBACILLUS

Lactobacillus compositions, especially those based on L. casei, and methods for the prevention and treatment of diseases or disorders involving or mediated by mast cells, such as anaphylaxis, allergy, autoimmune and inflammatory disorders including […]

USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK

The present invention relates to the prevention and/or treatment of arthritic, inflammatory and/or allergic reactions as well as thrombocytopenia, by blocking the human receptors FcyRI and FcyRIIA. It is disclosed a mouse monoclonal antibody […]

CV

Principal Investigator – Head of research unit Director of Research (DR1) @ INSERM & @ Institut Pasteur 2001: PhD in Immunology 2010: HDR diploma (Authorization to mentor PhD students) Publons / ResearcherID: F-5567-2013

Publications

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