Use of microfluidic approaches to study Neutrophil Extracellular Trap formation
Netosis consists of the ejection of DNA filaments by activated neutrophils resulting in extracellular DNA (Neutrophil Extracellular Traps, NETs). This DNA has antimicrobial properties but is also toxic to surrounding tissues. NETs have recently […]
Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Clinical and pathological consequences of human anti-drug antibodies (NASA study)
Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK
The present invention relates to the prevention and/or treatment of arthritic, inflammatory and/or allergic reactions as well as thrombocytopenia, by blocking the human receptors FcyRI and FcyRIIA. It is disclosed a mouse monoclonal antibody […]
2019An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis, Sci Transl Med. 2019 Jul 10: Vol. 11, Issue 500, eaat1479 DOI: 10.1126/scitranslmed.aat1479 .
2018Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis., Sci Immunol. 2018 Apr 13;3(22). .
2018MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker, Cell Chem Biol 2018 Apr;25(4):483-493.e9.
2017Low end-tidal CO2 as a real-time severity marker of intra-anaesthetic acute hypersensitivity reactions., Br J Anaesth. 2017 Nov 1;119(5):908-917.
2017Neutrophil myeloperoxidase diminishes the toxic effects and mortality induced by lipopolysaccharide, J Exp Med, 2017; in press.
2016Trans-inhibition of activation and proliferation signals by Fc receptors in mast cells and basophils., Sci Signal. 2016 Dec 20;9(459):ra126..
2016In vivo effector functions of high-affinity mouse IgG receptor FcγRI in disease and therapy models., J Autoimmun. 2016 Oct 10. pii: S0896-8411(16)30183-4..
2016Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice., J Allergy Clin Immunol. 2016 Aug 24..
2016Mucosal mast cells are indispensable for the timely termination of Strongyloides ratti infection.fr, Mucosal Immunol. 2016 Jul 6..
2016IgG subclasses determine pathways of anaphylaxis in mice., J Allergy Clin Immunol. 2016 Apr 26. pii: S0091-6749(16)30158-0.
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