Use of microfluidic approaches to study Neutrophil Extracellular Trap formation
Netosis consists of the ejection of DNA filaments by activated neutrophils resulting in extracellular DNA (Neutrophil Extracellular Traps, NETs). This DNA has antimicrobial properties but is also toxic to surrounding tissues. NETs have recently […]
Role of platelets and their interactions in allergic diseases
Role of platelets and their interactions in allergic diseases that aims at understanding how platelets induce/promote/regulate antibody-induced allergic diseases, their interaction partners (myeloid cells, endothelium) and their dynamics.
Clinical and pathological consequences of human anti-drug antibodies (NASA study)
Clinical and pathological consequences of human anti-drug antibodies (NASA study) that aims at demonstrating in the clinic that neutrophils are activated by antibody-curare complexes and involved in curare-induced anaphylaxis (allergic shock) in humans, and […]
USE OF ANTl-FcyRI AND/OR ANTl-FcyRllA ANTIBODIES FOR TREATING ARTHRITIS, INFLAMMATION, THROMBOCYTOPENIA AND ALLERGIC SHOCK
The present invention relates to the prevention and/or treatment of arthritic, inflammatory and/or allergic reactions as well as thrombocytopenia, by blocking the human receptors FcyRI and FcyRIIA. It is disclosed a mouse monoclonal antibody […]
2021Platelet FcγRIIA-induced serotonin release exacerbates the severity of Transfusion-Related Acute Lung Injury in mice, Blood Adv. 2021 Sep 14;bloodadvances.2021004336.
2021Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome, J Exp Med. 2021 Oct 4;218(10):e20201466. doi: 10.1084/jem.20201466.
2021The role of IgG subclasses and platelets in experimental anaphylaxis., J Allergy Clin Immunol 2021 Jan; (): .
2020Cofilin1-driven Actin Dynamics Controls Migration of Thymocytes and Is Essential for Positive Selection in the Thymus, J Cell Sci. 2020 Mar 6;133(5):jcs238048..
2020Human IgA binds a diverse array of commensal bacteria, J. Exp. Med. 2020 Mar;217(3).
2020Mouse Models and Tools for the in vivo Study of Neutrophils., Front Immunol. 2020 Jan 21;10:3130..
2019Expression, Role, and Regulation of Neutrophil Fcγ Receptors., Front Immunol. 2019 Aug 27;10:1958. Review..
2019An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis, Sci Transl Med. 2019 Jul 10: Vol. 11, Issue 500, eaat1479 DOI: 10.1126/scitranslmed.aat1479 .
2018MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker., Cell Chem Biol 2018 04; 25(4): 483-493.e9.
2018Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis., Sci Immunol. 2018 Apr 13;3(22). .
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