This is an example of transplanted human iPSC derived cells.
About
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Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
Publications
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2022Nicotinic receptors as SARS-CoV-2 spike co-receptors?, Med Hypotheses 2022 Jan; 158(): 110741.
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2021SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation., EMBO J 2021 12; 40(24): e108944.
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2021Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex, Cell Rep 2021 Nov; 37(8): 110035.
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2021An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions., Nat Commun 2021 11; 12(1): 6384.
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2021CD147 Promotes Tumor Lymphangiogenesis in Melanoma via PROX-1., Cancers (Basel) 2021 Sep; 13(19): .
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2021Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety., Neuron 2021 08; 109(16): 2604-2615.e9.
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2021Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia., Int J Mol Sci 2021 Jun; 22(13): .
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2021Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog Neurobiol 2021 02; 197(): 101898.
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2021Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality., Curr Res Neurobiol 2021 ; 2(): 100018.
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2020The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis., Arthritis Rheumatol 2020 12; 72(12): 2072-2082.
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