This is an example of transplanted human iPSC derived cells.
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Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
Publications
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2020Nicotinic Receptor Subunits Atlas in the Adult Human Lung., Int J Mol Sci 2020 Oct; 21(20): .
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2020Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog. Neurobiol. 2020 Aug; (): 101898.
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2020Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome., Elife 2020 Aug; 9(): .
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2020A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation., Sci Rep 2020 Aug; 10(1): 13315.
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2020Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution., Neuropharmacology 2020 Jul; 177(): 108234.
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2020The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse., Biomolecules 2020 07; 10(7): .
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2020The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis., 2020 Jul; (): .
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2020Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex., Dev. Biol. 2020 May; 461(1): 86-95.
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2020β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement., J. Neurosci. 2020 Apr; 40(17): 3465-3477.
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2020The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges., J. Neurochem. 2020 Aug; 154(3): 241-250.
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