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  • Visiting Scientist
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  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Uwe Maskos
Tranche d'hippocampe de souris colorée avec deux toxines spécifiques de sous-types de récepteur nicotinique, en rouge (grains), et en vert (corps cellulaires). L'hippocampe est la zone du cerveau qui gère la mémoire spatiale.

About

This is an example of transplanted human iPSC derived cells.

Transversal Projects

Brain connectivity and neurodegenerative diseases

The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]

Major Federating Program Microbes & Brain

Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]

Projects

Project
Ongoing
3 Members

Analysis of human iPSC derived neurons in vivo

Uwe Maskos (PI)

[Version française]… One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human […]
Project
Ongoing
5 Members

Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.

Morgane Besson (PI)

[Version française]… Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, […]
Project
Ongoing
4 Members

Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

Pierre-Jean Corringer (PI)
Project
Ongoing
8 Members

MECANICOC

Uwe Maskos (PI)

[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]
Project
Ongoing
3 Members

Role of the nicotinic receptor in Alzheimer’s disease pathology

Uwe Maskos (PI)

[Version française]… There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of […]
Project
Ongoing
2 Members

A Project of Integrative Neurobiology

Uwe Maskos (PI)

[Version française]… Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, […]

CV

Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.

Publications

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