This is an example of transplanted human iPSC derived cells.
Brain connectivity and neurodegenerative diseases
The brain is a complex organ, and its well-being depends on the harmonic interactions with the rest of our body. Nearly all brain disorders manifest themselves in the dysfunction of communication between brain cells […]
Analysis of human iPSC derived neurons in vivo
[Version française]… One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human […]
Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.
[Version française]… Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, […]
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]
Role of the nicotinic receptor in Alzheimer’s disease pathology
[Version française]… There is experimental and biomedical evidence that the nicotinic acetylcholine receptor (nAChR) is implicated in Alzheimer’s Disease (AD) pathology. The only reasonably efficient FDA approved treatment for early stage AD, blockers of […]
A Project of Integrative Neurobiology
[Version française]… Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, […]
Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
2023Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor., Cell Mol Life Sci 2023 May; 80(6): 164.
2023Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero., Cells 2023 Mar; 12(7): .
2023Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice., Neuropsychopharmacology 2023 Mar; (): .
2022[Nicotinic acetylcholine receptor and chronic obstructive pulmonary disease]., Med Sci (Paris) ; 38(8-9): 637-639.
2022The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients., Cells 2022 Sep; 11(19): .
2022Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice., Endocrinology 2022 Jul; 163(7): .
2022Nicotinic receptors as SARS-CoV-2 spike co-receptors?, Med Hypotheses 2022 Jan; 158(): 110741.
2021SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation., EMBO J 2021 12; 40(24): e108944.
2021Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex, Cell Rep 2021 Nov; 37(8): 110035.
2021An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions., Nat Commun 2021 11; 12(1): 6384.
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