This is an example of transplanted human iPSC derived cells.
Analysis of human iPSC derived neurons in vivo
One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human induced pluripotent […]
Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.
Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, certain subpopulations […]
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. nAChRs alpha5 […]
A Project of Integrative Neurobiology
Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, electrophysiological, behavioural […]
Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
2020β4-nicotinic receptors are critically involved in reward-related behaviors and self-regulation of nicotine reinforcement, J. Neurosci. 2020 Mar;.
2020The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: functional dissection and remaining challenges, J. Neurochem. 2020 Feb;:e14989.
2020Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex, Dev. Biol. 2020 Jan;.
2019β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward, Proc. Natl. Acad. Sci. U.S.A. 2019 Nov;.
2019A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency, Elife 2019 Oct;8.
2019Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior, Neuropsychopharmacology 2019 Jul;.
2018Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease, Physiol. Behav. 2019 02;199:265-272.
2018A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats, Curr. Biol. 2018 Oct;28(20):3244-3253.e7.
2018Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors, Elife 2018 Sep;7.
2018Induced pluripotent stem cells as a tool to study brain circuits in autism-related disorders, Stem Cell Res Ther 2018 Aug;9(1):226.
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