This is an example of transplanted human iPSC derived cells.
Analysis of human iPSC derived neurons in vivo
One of the main obstacles for studying the molecular and cellular mechanisms underlying human neurodevelopment in vivo is the scarcity of experimental models. The discovery that neurons can be generated from human induced pluripotent […]
Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.
Drug addiction is a complex psychiatric disorder. Several predisposing factors can contribute to the vulnerability to develop this pathology, including environmental and genetic ones. Although smoking prevalence has declined in recent years, certain subpopulations […]
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. nAChRs alpha5 […]
A Project of Integrative Neurobiology
Understanding mechanisms underlying normal complex behaviours and the abnormalities that accompany most neuropathologies is a primary challenge in fundamental and biomedical research. However, optimal use of the large body of genetic, molecular, electrophysiological, behavioural […]
Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
2020Nicotinic Receptor Subunits Atlas in the Adult Human Lung., Int J Mol Sci 2020 Oct; 21(20): .
2020Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog. Neurobiol. 2020 Aug; (): 101898.
2020Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome., Elife 2020 Aug; 9(): .
2020A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation., Sci Rep 2020 Aug; 10(1): 13315.
2020Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution., Neuropharmacology 2020 Jul; 177(): 108234.
2020The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse., Biomolecules 2020 07; 10(7): .
2020The role of the non-neuronal cholinergic system in inflammation and degradation processes in osteoarthritis., 2020 Jul; (): .
2020Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex., Dev. Biol. 2020 May; 461(1): 86-95.
2020β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement., J. Neurosci. 2020 Apr; 40(17): 3465-3477.
2020The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges., J. Neurochem. 2020 Aug; 154(3): 241-250.
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