Timeline
Uwe Maskos
Head of Structure
14 Mar 2024
publication
Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation
Read more12 Jan 2024
event
Neuroscience Departmental Seminar “Neurocognitive impact of juvenile obesity: circuit-specific memory deficits, endocannabinoid system involvement and gender differences.”
Read more25 Sep 2023
publication
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Read more25 May 2023
publication
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Read more31 Mar 2023
publication
Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero.
Read more17 Mar 2023
publication
Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice.
Read more01 Jan 2023
publication
Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue.
Read more13 Oct 2022
20 Sep 2022
publication
The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients.
Read more01 Jul 2022
publication
Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice.
Read more01 Jan 2022
15 Dec 2021
publication
SARS-CoV-2 Alpha, Beta, and Delta variants display enhanced Spike-mediated syncytia formation.
Read more14 Dec 2021
14 Dec 2021
news
CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A GENETIC MUTATION CONFIRMED AS PREDISPOSING FACTOR
Read more23 Nov 2021
publication
Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex
Read more04 Nov 2021
publication
An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions.
Read more28 Sep 2021
18 Aug 2021
22 Jun 2021
publication
Chr15q25 Genetic Variant rs16969968 Alters Cell Differentiation in Respiratory Epithelia.
Read more04 May 2021
01 Feb 2021
publication
Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients.
Read more01 Jan 2021
publication
Cholinergic modulation of hierarchical inhibitory control over cortical resting state dynamics: Local circuit modeling of schizophrenia-related hypofrontality.
Read more01 Dec 2020
publication
The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis.
Read more09 Nov 2020
15 Oct 2020
publication
Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution.
Read more09 Oct 2020
12 Aug 2020
publication
Alterations of specific cortical GABAergic circuits underlie abnormal network activity in a mouse model of Down syndrome.
Read more07 Aug 2020
publication
A chimeric mouse model to study human iPSC-derived neurons: the case of a truncating SHANK3 mutation.
Read more01 Aug 2020
publication
The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges.
Read more16 Jul 2020
publication
The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse.
Read more01 May 2020
publication
Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex.
Read more22 Apr 2020
publication
β4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement.
Read more17 Feb 2020
27 Nov 2019
publication
β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward.
Read more30 Oct 2019
publication
A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency.
Read more01 Oct 2019
publication
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.
Read more01 Oct 2019
publication
Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior.
Read more06 Jul 2019
01 Jan 2019
publication
Human Autoantibodies Against N-Methyl-D-Aspartate Receptor Modestly Alter Dopamine D1 Receptor Surface Dynamics.
Read more01 Jan 2019
publication
Corticosteroid-Binding Globulin Deficiency Specifically Impairs Contextual and Recognition Memory Consolidation in Male Mice.
Read more27 Nov 2018
publication
Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in Aβ- induced Alzheimer disease
Read more22 Oct 2018
publication
A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats.
Read more04 Sep 2018
publication
Manipulating midbrain dopamine neurons and reward-related behaviors with light-controllable nicotinic acetylcholine receptors.
Read more01 Sep 2018
publication
iPlasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants.
Read more23 Aug 2018
publication
Induced pluripotent stem cells as a tool to study brain circuits in autism-related disorders
Read more13 Aug 2018
publication
Gender-specific study of recurrent suicide attempts in outpatients with multiple substance use disorders
Read more01 Jul 2018
publication
Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity.
Read more01 Jun 2018
publication
Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria.
Read more01 Jun 2018
publication
Relevance of treated cocaine users’ retrospective memory of first cocaine use.
Read more27 Mar 2018
publication
Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
Read more02 Mar 2018
project
Studying vulnerability to drug addiction: contribution of the nicotinic acetylcholine receptor α5 subunit.
Read more01 Mar 2018
publication
GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.
Read more27 Feb 2018
project
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Read more24 Jan 2018
01 Jan 2018
publication
Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons.
Read more01 Jan 2018
publication
Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy.
Read more01 Oct 2017
publication
Transcriptome of melanoma cells from two mouse models, Tyr:NRasQ61K and Tyr:Rack1-HA, Tyr:NRasQ61K.
Read more01 Aug 2017
02 Mar 2017
01 Mar 2017
publication
Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.
Read more01 Feb 2017
publication
Human polymorphisms in nicotinic receptors: a functional analysis in iPS-derived dopaminergic neurons.
Read more23 Jan 2017
01 Jan 2017
publication
A novel adjustable automated system for inducing chronic intermittent hypoxia in mice.
Read more20 Dec 2016
publication
Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex.
Read more20 Dec 2016
publication
Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.
Read more20 Dec 2016
publication
Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex
Read more10 Dec 2016
publication
Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.
Read more01 Oct 2016
publication
A role for β2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus.
Read more01 Sep 2016
publication
Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.
Read more01 Aug 2016
publication
Chronic stress does not further exacerbate the abnormal psychoneuroendocrine phenotype of Cbg-deficient male mice.
Read more01 Jun 2016
publication
Role of β4* Nicotinic Acetylcholine Receptors in the Habenulo-Interpeduncular Pathway in Nicotine Reinforcement in Mice.
Read more10 May 2016
publication
CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders
Read more01 Mar 2016
publication
Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking.
Read more02 Nov 2015
event
NEUROSCIENCE SEMINAR : Pr. Salah El Mestikawy “Regulation of reward circuits and addiction by VGLUT3 and cholinergic interneurons from the nucleus accumbens”
Read more15 Oct 2015
publication
The multiple roles of the α7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system.
Read more30 Sep 2015
publication
New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates
Read more20 Sep 2015
01 Sep 2015
publication
Role of the nicotinic acetylcholine receptor in Alzheimer’s disease pathology and treatment.
Read more01 Sep 2015
01 Aug 2015
publication
Crucial role of nicotinic α5 subunit variants for Ca2+ fluxes in ventral midbrain neurons.
Read more03 Jul 2015
01 Jun 2015
publication
EMMPRIN regulates β1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells.
Read more13 May 2015
publication
The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors.
Read more12 May 2015
publication
High-throughput somatic mutation profiling in pulmonary sarcomatoid carcinomas using the LungCarta™ Panel: exploring therapeutic targets
Read more11 May 2015
01 Jan 2015
publication
EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.
Read more01 Jan 2015
publication
Differential roles of α6β2* and α4β2* neuronal nicotinic receptors in nicotine- and cocaine-conditioned reward in mice.
Read more01 Dec 2014
publication
Role of corticosteroid binding globulin in emotional reactivity sex differences in mice.
Read more17 Sep 2014
01 Sep 2014
publication
The novel α7β2-nicotinic acetylcholine receptor subtype is expressed in mouse and human basal forebrain: biochemical and pharmacological characterization.
Read more01 Aug 2014
publication
The α3β4* nicotinic ACh receptor subtype mediates physical dependence to morphine: mouse and human studies
Read more01 Aug 2014
publication
Nicotine consumption is regulated by a human polymorphism in dopamine neurons.
Read more01 May 2014
publication
Concomitant alpha7 and beta2 nicotinic AChR subunit deficiency leads to impaired energy homeostasis and increased physical activity in mice.
Read more01 Jan 2014
publication
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations
Read more11 Sep 2013
publication
Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb
Read more01 Jun 2013
publication
Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling.
Read more05 Mar 2013
publication
Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.
Read more01 Mar 2013
01 Aug 2012
publication
Selective re-expression of β2 nicotinic acetylcholine receptor subunits in the ventral tegmental area of the mouse restores intravenous nicotine self-administration.
Read more05 Jul 2012
publication
Receptor-type tyrosine phosphatase ligands: looking for the needle in the haystack
Read more01 May 2012
publication
Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.
Read more15 Feb 2012
publication
Striatal α5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum.
Read more01 Oct 2011
publication
Smoke extracts and nicotine, but not tobacco extracts, potentiate firing and burst activity of ventral tegmental area dopaminergic neurons in mice.
Read more12 Aug 2011
publication
Nicotinic acetylcholine receptor β2 subunits in the medial prefrontal cortex control attention.
Read more01 Aug 2011
publication
Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+.
Read more01 Jul 2011
12 May 2011
publication
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula.
Read more03 May 2011
publication
Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine.
Read more01 Jan 2011
publication
Antibodies against extracellular domains of α4 and α7 subunits alter the levels of nicotinic receptors in the mouse brain and affect memory: possible relevance to Alzheimer’s pathology
Read more01 Dec 2010
publication
α-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between α6ß4 and α6ß2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release.
Read more01 Aug 2010
publication
Role of endogenous acetylcholine in the control of the dopaminergic system via nicotinic receptors.
Read more01 Aug 2010
publication
Peroxisome proliferator-activated receptors-alpha modulate dopamine cell activity through nicotinic receptors.
Read more01 Mar 2010
publication
A versatile system for the neuronal subtype specific expression of lentiviral vectors.
Read more01 Feb 2010
publication
Effect of the alpha4beta2* nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in beta2 knock-out mice with selective re-expression of the beta2 subunit in the ventral tegmental area.
Read more18 Nov 2009
publication
Functional effects of antibodies against non-neuronal nicotinic acetylcholine receptors
Read more25 Dec 2008
publication
Regional changes in the cholinergic system in mice lacking monoamine oxidase A
Read more19 Nov 2008
publication
Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration.
Read more01 Nov 2008
publication
Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration.
Read more14 Oct 2008
publication
Interplay of beta2* nicotinic receptors and dopamine pathways in the control of spontaneous locomotion.
Read more08 Oct 2008
publication
Regional differential effects of chronic nicotine on brain alpha 4-containing and alpha 6-containing receptors
Read more01 Mar 2008
publication
The cholinergic mesopontine tegmentum is a relatively neglected nicotinic master modulator of the dopaminergic system: relevance to drugs of abuse and pathology.
Read more01 Dec 2007
publication
Loss of high-affinity nicotinic receptors increases the vulnerability to excitotoxic lesion and decreases the positive effects of an enriched environment.
Read more10 Apr 2007
publication
Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures
Read more01 Feb 2007
publication
Emerging concepts: novel integration of in vivo approaches to localize the function of nicotinic receptors.
Read more15 Nov 2006
publication
Nicotine and serotonin in immune regulation and inflammatory processes: a perspective
Read more01 Nov 2006
publication
Live imaging of neural structure and function by fibred fluorescence microscopy.
Read more15 Jun 2006
publication
Hierarchical control of dopamine neuron-firing patterns by nicotinic receptors.
Read more01 Jan 2006
publication
Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.
Read more01 Jan 2006
publication
Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors.
Read more20 Jul 2005
publication
Altered map of visual space in the superior colliculus of mice lacking early retinal waves
Read more07 Jul 2005
publication
Nicotine reinforcement and cognition restored by targeted expression of nicotinic receptors.
Read more10 Dec 2004
publication
5-HT activates ERK MAP kinase in cultured-human peripheral blood mononuclear cells via 5-HT1A receptors
Read more01 Oct 2003
publication
Neural cells without functional N-Methyl-D-Aspartate (NMDA) receptors contribute extensively to normal postnatal brain development in efficiently generated chimaeric NMDA R1 -/- +/+ mice
Read more01 Feb 2003
publication
Differential effect of serotonin on cytokine production in lipopolysaccharide-stimulated human peripheral blood mononuclear cells: involvement of 5-hydroxytryptamine2A receptors
Read more23 Jul 2002
publication
Retrograde trans-synaptic transfer of green fluorescent protein allows the genetic mapping of neuronal circuits in transgenic mice.
Read more01 Mar 2001
publication
Long-term survival, migration, and differentiation of neural cells without functional NMDA receptors in vivo
Read more01 Jan 2001
publication
Immunodepression in sepsis and SIRS assessed by ex vivo cytokine production is not a generalized phenomenon: a review
Read more01 Jan 1999
publication
5-HT1B receptors modulate release of [3H]dopamine from rat striatal synaptosomes
Read more15 Dec 1998
publication
Molecular, cellular and physiological characteristics of 5-HT-moduline, a novel endogenous modulator of 5-HT1B receptor subtype
Read more06 Jul 1998
publication
Mapping of 5-HT-moduline binding sites in guinea-pig brain by film and digital autoradiography
Read more02 Sep 1997
publication
Autoradiographic characterization of [3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT1B receptors
Read more01 May 1997
publication
The in situ hybridization and immunocytochemistry techniques for characterization of cells expressing specific mRNAs in paraffin-embedded brains
Read more01 Oct 1996
publication
5-hydroxytryptamine-moduline, a new endogenous cerebral peptide, controls the serotonergic activity via its specific interaction with 5-hydroxytryptamine1B/1D receptors
Read more01 Mar 1996
publication
Cellular localization of 5-HT1B receptor mRNA in the rat olfactory tubercle: do GABAergic neurons express the 5-HT1B gene?
Read more29 Dec 1995
publication
Effects of stress on the functional properties of pre- and postsynaptic 5-HT1B receptors in the rat brain
Read more01 Dec 1995
publication
Production and characterization of an antibody directed against the mouse 5HT1B receptor
Read more01 Dec 1995
publication
Host-guided migration allows targeted introduction of neurons into the embryonic brain
Read more30 Jun 1994
publication
Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides
Read more11 Oct 1993
publication
A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support
Read more11 May 1993
publication
A novel method for the analysis of multiple sequence variants by hybridisation to oligonucleotides
Read more11 May 1993
publication
A novel method for the parallel analysis of multiple mutations in multiple samples
Read more01 May 1993
publication
[Fundamental aspects of molecular biology. The multigene family of 5-HT1 receptors]
Read more01 Jan 1993
01 Aug 1992
publication
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models
Read more11 Apr 1992
publication
Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation
Read more11 Apr 1992
publication
Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ
Read more01 Jan 1992
publication
Molecular cloning of two partial serotonin 5-HT1D receptor sequences in mouse and one in guinea pig
Read more01 Jan 1992
publication
Inhibition of [3H] gamma-aminobutyric acid release from guinea-pig hippocampal synaptosomes by serotonergic agents
Read more01 May 1991
publication
Antagonism by antidepressant drugs of the inhibitory effect of trifluoromethylphenylpiperazine (TFMPP) on [3H]acetylcholine release in rat or guinea-pig hippocampal synaptosomes.
Read more01 Jan 1991
publication
A cerebral endogenous factor regulates the activity of the serotonergic receptors modulating the neuronal release of acetylcholine.
Read more01 Jan 1991
publication
The inhibitory effect of trifluoromethylphenylpiperazine on [3H]acetylcholine release in guinea pig hippocampal synaptosomes is mediated by a 5-hydroxytryptamine1 receptor distinct from 1A, 1B, and 1C subtypes.
Read more16 Oct 1989
publication
Sodium-dependent high-affinity uptake of taurine by isolated rat brain capillaries.
Read more01 Sep 1989
publication
Antioxidant enzymes and related trace elements in aging brain capillaries and choroid plexus.
Read more01 May 1989
publication
Alterations in protective enzymes against peroxidation in the central and peripheral nervous system of control and dysmyelinating mutant mice.
Read more16 Dec 1987
publication
Copper, manganese and zinc in the developing brain of control and quaking mice.
Read more12 Oct 1987
publication
Alterations of lipid synthesis in the normal and dysmyelinating trembler mouse sciatic nerve by heavy metals (Hg, Pb, Mn, Cu, Ni).
Read more01 Jan 1987
publication