trained as a chemist and did my PhD (Paris) and post-doctoral fellowship (Brighton) in organic synthesis. He then joined the Pasteur Institute as a CNRS researcher to work on nicotinic acetylcholine receptors, and contributed to the discovery of bacterial homologues of these neurotransmitter receptors. In 2008, I created a research group, to decipher the allosteric mechanisms of bacterial and eukaryotic channel receptors by combining structural, electrophysiological and fluorescence approaches.
Click to view graph
Connections
Click to view timeline
Timeline
Projects
CV
Current Position
Research Director DR1 at the CNRS
Co-director of the CNRS Unit “Genes, Synapses and Cognition”
Co-director of the Neuroscience department of the Institut Pasteur
Education / Cursus
1988 Engineer in Chemistry (ESCIL, Lyon).
1992 Ph.D. Pharmacochemistry (Paris V University).
1992-1993 Post-doctoral fellow (Welcome trust) at Brighton University (U.K.).
1993-2006 Research Scientist at the CNRS, Receptor and Cognition unit (J.P. Changeux), Institut Pasteur.
2006-2012 Research Director at the CNRS. Head of a G5 research group, Institut Pasteur.
Awards
2009: Pasteur Vallery-Radot award
2013: Andrée et René Duquesnes award
2014: Elected member of Academia Europa
2015: Grand Prix Emile Jungfleisch from the French academy of sciences
2018: Silver medal of the CNRS
2018: Awarded and ERC advanced grant
Publications
Download-
2020The desensitization pathway of GABAA receptors, one subunit at a time., Nat Commun 2020 10; 11(1): 5369.
-
2020Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog. Neurobiol. 2020 Aug; (): 101898.
-
2019Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors, ACS Chem Neurosci 2019 May;10(5):2551-2559.
-
2018Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel, Proc. Natl. Acad. Sci. U.S.A. 2018 12;115(52):E12172-E12181.
-
2018Conformational transitions of the serotonin 5-HT receptor, Nature 2018 11;563(7730):275-279.
-
2018Structural titration of receptor ion channel GLIC gating by HS-AFM, Proc. Natl. Acad. Sci. U.S.A. 2018 10;115(41):10333-10338.
-
2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
-
2018The dual-gate model for pentameric ligand-gated ion channels activation and desensitization, J. Physiol. (Lond.) 2018 Feb;.
-
2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel, PLoS Biol. 2017 12;15(12):e2004470.
-
2017Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors, Sci Rep 2017 Nov;7(1):16606.
-
+View full list of publications