Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)
Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. nAChRs alpha5 […]
Research Director DR1 at the CNRS
Co-director of the CNRS Unit “Genes, Synapses and Cognition“
Education / Cursus
1988 Engineer in Chemistry (ESCIL, Lyon).
1992 Ph.D. Pharmacochemistry (Paris V University).
1992-1993 Post-doctoral fellow (Welcome trust) at Brighton University (U.K.).
1993-2006 Research Scientist at the CNRS, Receptor and Cognition unit (J.P. Changeux), Institut Pasteur.
2006-2012 Research Director at the CNRS. Head of a G5 research group, Institut Pasteur.
2009: Pasteur Vallery-Radot award
2013: Andrée et René Duquesnes award
2014: Elected member of Academia Europa
2015: Grand Prix Emile Jungfleisch from the French academy of sciences
2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
2018The dual-gate model for pentameric ligand-gated ion channels activation and desensitization, J. Physiol. (Lond.) 2018 Feb;.
2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel, PLoS Biol. 2017 12;15(12):e2004470.
2017Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors, Sci Rep 2017 Nov;7(1):16606.
2016Interaction of three-finger proteins from snake venoms and from mammalian brain with the cys-loop receptors and their models, Dokl. Biochem. Biophys. 2016 May;468(1):193-6.
2016Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory pain, J. Clin. Invest. 2016 Jul;126(7):2547-60.
2016Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis, J. Mol. Biol. 2016 Jul;428(14):2898-915.
2016Emerging Molecular Mechanisms of Signal Transduction in Pentameric Ligand-Gated Ion Channels, Neuron 2016 05;90(3):452-70.
2016Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus), Toxicon 2016 Jun;116:63-71.
2015Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors, Alcohol. Clin. Exp. Res. 2015 Jun;39(6):962-8.
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