Elucidating the structural dynamics of a PENTAMERIC LIGAND-GATED ION CHANNEL for rational DRUG design
ERC advanced DYNACOTINE
Signal transduction and allosteric modulation of nicotinic acetylcholine receptors: from ion channel electrophysiology to atomic 3D structures
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Discovery of allosteric modulators specifically targeting α5-containing nAChRs. (ANR-Nicofive)
[Version française]… Cocaine addiction (CocAdd) is a major public health issue affecting 3% of the worlwide population, without validated pharmacotherapy. Nicotinic acetylcholine receptors (nAChRs)have been repeatedly associated in Human and rodent response to cocaine. […]
Research Director DR1 at the CNRS
Co-director of the CNRS Unit “Genes, Synapses and Cognition”
Co-director of the Neuroscience department of the Institut Pasteur
Education / Cursus
1988 Engineer in Chemistry (ESCIL, Lyon).
1992 Ph.D. Pharmacochemistry (Paris V University).
1992-1993 Post-doctoral fellow (Welcome trust) at Brighton University (U.K.).
1993-2006 Research Scientist at the CNRS, Receptor and Cognition unit (J.P. Changeux), Institut Pasteur.
2006-2012 Research Director at the CNRS. Head of a G5 research group, Institut Pasteur.
2009: Pasteur Vallery-Radot award
2013: Andrée et René Duquesnes award
2014: Elected member of Academia Europa
2015: Grand Prix Emile Jungfleisch from the French academy of sciences
2018: Silver medal of the CNRS
2018: Awarded and ERC advanced grant
2021Mutational analysis to explore long-range allosteric couplings involved in a pentameric channel receptor pre-activation and activation., Elife 2021 Sep; 10(): .
2021Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients., Prog Neurobiol 2021 02; 197(): 101898.
2020The desensitization pathway of GABAA receptors, one subunit at a time., Nat Commun 2020 10; 11(1): 5369.
2019Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors, ACS Chem Neurosci 2019 May;10(5):2551-2559.
2018Electrostatics, proton sensor, and networks governing the gating transition in GLIC, a proton-gated pentameric ion channel, Proc. Natl. Acad. Sci. U.S.A. 2018 12;115(52):E12172-E12181.
2018Conformational transitions of the serotonin 5-HT receptor, Nature 2018 11;563(7730):275-279.
2018Structural titration of receptor ion channel GLIC gating by HS-AFM, Proc. Natl. Acad. Sci. U.S.A. 2018 10;115(41):10333-10338.
2018The dual-gate model for pentameric ligand-gated ion channels activation and desensitization., J Physiol 2018 05; 596(10): 1873-1902.
2018Crystal structures of a pentameric ion channel gated by alkaline pH show a widely open pore and identify a cavity for modulation, Proc. Natl. Acad. Sci. U.S.A. 2018 04;115(17):E3959-E3968.
2017Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel, PLoS Biol. 2017 12;15(12):e2004470.
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