Pierre-Marie Lledo

Much of our adult behaviors reflect the state of neural circuits sculpted by sensory experience in infancy and early childhood. At no other time in life does the surrounding environment so potently shape most of the brain functions – from basic motor skills or perception to higher cognitive processes like language. However, the existence of neural stem cells in the adult mammalian CNS, including humans, suggests previously unrealized neural plasticity where some circuits are endowed with a never-ending critical window, and thus remain sensitive to sensory experience, reward values and/or distinct brain states (emotion, etc.), throughout life. I seek to tackle the question of the meaning of adult brain plasticity brought into play by late neurogenesis. I’m particularly interested in determining the conditions that regulate the degree of adult neurogenesis and in turn the impact of adult neurogenesis on cognitive and affective functions, both in animal models and human beings.

BIOGRAPHICAL SKETCH

Pierre-Marie Lledo                                                                                   Phone: +33-145-688-803
The Pasteur Institute and CNRS,                                                              Fax: +33-145-688-369
25, rue du Dr. Roux, 75724 Paris, France.                                               E-mail: pmlledo@pasteur.fr

 Education / Training
1998 –  Habilitation (Paris XI University, School of Medicine).
1991  –   Ph.D. in Neuroscience (“Summa cum laude”, Bordeaux University).
1986 –   Ecole Normale Superieure (Cachan, Life Science).

 Current Positions
Chairman of the Department of Neuroscience at the Pasteur Institute

Head of the Laboratory “Perception and Memory” at the Pasteur Institute

Director of the Unit “Genes, Synapses and Cognition” at the French Center for Scientific Research (CNRS)

Director of the Teaching Graduate Program “Neuroscience” at the Pasteur Institute

Professional positions held
2012-2015      –   Member of the Scientific Council of Endowed International Chairs « Blaise Pascal ».

Since 2009       –   Chairman of the Scientific Council of the FNRS (Belgium).

2009-2014       –   Member of the Scientific Council of “Biovision” (The World Life Sciences Forum).

2009-2012      –   Vice-president of the Scientific Council at the Institut Pasteur.

2009-2014      –   Faculty member of the Universita’ di Torino (Italy).

2008 – 2012       –   Panel Expert at the European Commission (FP7 and ERA-Net program).

2007-2014       –   Member of the PhD program committee (Ecole Doctorale 3C) at University Paris VI.

2007-2009      –   Member of the Scientific Council of the Institut Pasteur.

2007 – 2013       –   Member of the Executive Council of the Paris Neuroscience Foundation (ENP).

2006-2014       –   Coordinator of the Network of European Neuroscience Institutes in Paris (ENINET).

Since 2004       –   Director of a Research Unit at the CNRS (UMR 3571, Paris, France).

Since 2003       –   Senior Scientist at the CNRS (DR1) at the Institut Pasteur in Paris (France).

2001-2003      –   Senior Scientist at the CNRS (DR2) in Gif-sur-Yvette (France).

Since 2001       –   Head of a Research Unit at the Institut Pasteur in Paris (France)

1997-2000      –   Associate Researcher (tenured position, CR1) at the CNRS in Gif-sur-Yvette (France).

1995-1997      –   Visiting Scientist (NSF & NIH fellowships) at U.C.S.F. (USA).

1992-1995      –   Assistant Researcher (tenured position, CR2) at the CNRS in Gif-sur-Yvette (France).

1991-1992      –   Post-doctoral fellow (Wellcome trust) at Cambridge University (U.K.).

Teaching Experience / Organizing meetings

June 2016        –   Organizer, Symposium “Olfactory Plasticity” for ISOT (Yokohama, Japan)

March 2013     –   Organizer, Symposium “Lifestyle diseases” for Biovision (Lyon, France)

Sept. 2012       –   Organizer, Les Treilles Meeting: Cognitive Development (Nice, France)

October 2011  –   Organizer, Les Treilles Meeting: Neuronal Development (Nice, France)

March 2011     –   Organizer, Biovision: The Social Brain (Lyon, France)

January 2011   –   Organizer, Keystone Symposia: Adult Neural Stem Cells (Taos, USA)

June 2009        –   Organizer, International Meeting: Neurosciences and Marketing (Tours, France)

March. 2008    –   Organizer, International Meeting: Brain plasticity (Paris, France)

Sept. 2007       –   Organizer, Pasteur Institute: A tribute to Jean-Pierre Changeux (Paris, France)

Sept. 2007       –   Organizer, Les Treilles Meeting: Olfactory systems (Nice, France)

Sept. 2006       –   Organizer, International Meeting: Stem Cells (Paris, France)

March 2005     –   Organizer, International Meeting: Sensory deficit (Paris, France)

Sept. 2004       –   Organizer, Les Treilles Meeting: Sensory systems (Nice, France)

April 2003       –   Organizer, International Workshop: Brain Variability (Paris, France)

Since 2003       –   Visiting Lecturer, Ecole Normale Supérieure (undergraduate, Cachan)

Since 2003       –   Visiting Lecturer, University of Marseille (undergraduate, France)

Since 2002       –   Visiting Lecturer, Ecole Normale Supérieure (undergraduate, Paris)

2002- 2006     –    Visiting Lecturer, Univ. of Versailles (PhD, France)

2002-2006      –   Visiting Lecturer, Inst. de Formation Supérieure Biomédicale (Paris)

Since 2001       –     Visiting Lecturer, Univ. of Paris VI (PhD program in Neuroscience)

March 2000     –   Visiting Lecturer, ESPCI, Paris (PhD program in Neuroscience)

1999-2004      –     Visiting Lecturer, University of Paris XI (PhD program in Neuroscience)

Dec. 1998        –   Instructor, INSERM Workshop: “Biotechnology applied to single cell”

Dec.1997         –   Instructor, CNRS Workshop: “Electrophysiology “ (Bordeaux, France)

Administrative Responsibilities / Referee / Editors

2008- 2012: Coordinator of The Stem Cells Collaborative Program in Paris (11 labs, 75 peoples, ENP).

Since 2007: Coordinator of The European Network of Neuroscience Institutes (ENI-NET).

Member of the Site Review Boards Post-transcriptome CNRS-Canada in 2007.

Member of the Executive Board Neuropole 2006-2007.

Member of EU Review Panels 2007, 2008, 2009, 2010.

2008-2010: Member of the Executive Board “Paris Neuroscience Foundation” (ENP).

Member of the Review Panel for the Deutsche Forschungsgemeinschaft (Olfaction) in 2009.

President, Site visits committee of the AERES (French research Natl. Agency) in Dijon (2009, 2011).

Member of the Site visits committee of the AERES in Bordeaux (2009).

President of the site visit committee of AERES in Dijon, 2011.

Grant Review (from 1996 onwards): France: CNRS, INSERM, Natl. Acad. of Science, French Res. Ministry, FRM, FRC, Neuropole, ANR and AERES) and Région Aquitaine; European Community (ERC and Marie Curie); U.K.: Wellcome Trust; Switzerland: SNF; Spain: CSIC; Belgium: FNRS; Italy: CNR; New Zealand: HRC; USA: NSF and NIH; Republic of Cyprus: Research Promotion Foundation; Israel: Israel Science Foundation and Weizmann Institute.

Thesis Referee (from 1997 onwards): 42 theses (in Belgium, France, Germany, Italy and Switzerland).

Since 2007: Review Editor for Frontiers in Neuroscience.

Since 2008: Associate Editor for Frontiers in Neurogenesis.

Since 2009: Associate Editor for Neural Systems & Circuits (BioMed Central).

Editor for Encyclopedia of Neuroscience, Springer Verlag (Berlin, 2009).

Editor for Textbook in Neurosciences, Springer Verlag (Berlin, 2012).

Since 2014: F1000Prime (Faculty Member).

Since 2014: F1000Research (Advisory Board Member).

Honors and Awards

1987-91: French Ministry of Education Research Scholarship.

1991-92: Welcome Trust Fellowship.

1995-97: National Science Foundation (NSF) and NIH Fellowships.

1995: CNRS Medal for the best Junior scientist.

1995: “Young Investigator” Award from Paris Academy.

1996: “Young Investigator” Award from Ministry of Defense and Technology  Researches (DRET).

2002: Award from the Schlumberger Foundation for Education & Research.

2004: First Award of the French National Academy of Medicine.

2005:  “NRJ” Award from the French National Academy of Science.

2006: Member of the Academia Europaea.

2007: Jaffé Award from the French National Academy of Science.

2009: Member of the New York Academy of Sciences.

2010: Award “Camille Woringer” from the Fondation pour la Recherche Médicale.

2011: Prize of Scientific Excellence (“Prime d’Excellence Scientifique”) of the CNRS.

2012: Award “Mémain-Pelletier” from the French National Academy of Science.

2012: Award “Grand Prix” from the Saintonge Academy.

2013: Award “Grand Prix” from the Fondation Prince Louis de Polignac.

2015: Grand Prix du Jury de la Fondation Internationale Roger de Spoelberch.

2017: Chaire d’excellence Elie Metchnikoff.

2018:  Prix X-Philo.

2020: Médaille d’Honneur du Cercle de Paris.

 Mentoring Graduate Students

1993 – 1995:  Annie Lannuzel (Ph.D. degree, Paris Univ.)

1997 – 2001: David Desmaisons (Ph.D. degree, Paris Univ.)

1997 – 2001: Alan Carleton (Ph.D. ENS, Paris Univ.)

1999 – 2002:  Christelle Rochefort (Ph.D. degree, Paris Univ.)

2000 – 2002: Javier Morante-Oria (Ph.D. degree, Paris Univ.)

2001 – 2006: Samuel Lagier (Ph.D. ENS, Paris Univ.)

2001 – 2006: Antoine DeChevigny (Ph.D. degree, Paris Univ.)

2001 – 2005: Morgane Lemasson (Ph.D. degree, Paris Univ.)

2004 – 2005: Catherine Kielar (Master degree, Paris Univ.)

2004 – 2005: Brice Bathelier (Master degree, ENS Paris Univ.)

2006 – 2009: Aurélie Mouret (Ph.D. ENS, Paris Univ.)

2008 – 2012: Marta Pallotto (Ph.D. degree, Paris Univ.)

2009 – 2010:  Bertrand Hermann (Ecole de l’Inserm, Paris VII)

2009 – 2010:  Aurélia Sahel (Master degree, Paris Univ.)

2010 – 2011: Isabelle Bourdet (Master degree, Paris Univ.)

2010 – 2011:  Walid Bouthour (Ecole de l’Inserm, Paris Univ.)

2011 – 2012: Andrew Sideris (Ph.D. ENP, Paris Univ.)

2013 – 2016: Marie Denizet (Ph.D. ENS, Paris Univ.)

2013 – 2016: Camille Mazo (Ph.D. ENS, Paris Univ.)

2016 – 2020: Soham Saha (Ph.D. ENP-Paris Univ.)

2016 – 2020: Maud Pascal (Ph.D. ENS, Paris Univ.)

2018 – 2021: Corentin Guerinot (Ecole Polytechnique, Paris Univ.)

Mentoring Postdoctoral Fellows

1993-1994: Serge Schiffmann (HSFP Fellow)

1993-1994: José-Antonio Lamas (CSIC Fellow)

1994-1997: Hassan Salim (AIDS Foundation Fellow)

1998-2000: Albert Hsia (FRM & Fyssen Fellow)

2001-2002:  Alan Carleton (Pasteur Institute Fellow)

2000-2005:  Armen Saghatelyan (Pasteur Institute Fellow)

2002-2004: Marc Davenne (HSFP & Schlumberger Foundation)

2003-2004: Xavier Grosmaitre (Pasteur Institute Fellow)

2004-2009 : Mariana Alonso (FRM Fellow)

2005- 2007:  Matt Grubb (Pierre & Marie Curie Fellow)

2005-2009:   Katagiri Hiroyuki (Pasteur Institute Fellow)

2005-2009:   Antoine Nissant (Schlumberger Foundation Fellow)

2006-2007:   Inmaculada Ortega-Pérez (ANR Fellow)

2006-2009:   Sheyla Mejia (ANR Fellow)

2008-2010:   Claudia Feistein (Paris Neuroscience Foundation Fellow)

2008-2010:   Cedric Bardy (ANR Fellow)

2008-2011:   Richard Belvindrah (ARC Fellowship)

2009-2014:   Gabriel Lespousez (FRM Fellowship)

2010-2014:   Benjamin Gallarda (Foundation Pasteur Fellowship)

2010-2014:   Matt Valley (EU-FP7 Fellowship)

Since 2011:   Martin Wiechert (Pasteur Institute Fellowship)

Since 2012:   Kurt Sailor (Pasteur Institute Fellowship)

Since 2014:   Aleksandra Polosukhina (Foundation Pasteur Fellowship)

Since 2012:   Eleni Siopi (ANR Fellow)

Since 2015: Lida Katsipardi (Labex Revive)

Since 2015: Damien Rei (ANR & Marie Curie H2020 fellowship).

Since 2016: Ilana Gabanyi (HFSP fellowship and ANR)

Since 2020: Erwant Poivet (Foundation PerFumum)

Bibliography

Selected Main Research Articles

1. Bigot M, Alonso M, Houenou J, Sarrazin S, Dargél AA, Lledo PM et Henry C (2020) An emotional-response model of bipolar disorders integrating recent findings on amygdala circuits. Neurosci Biobehav Rev. 118, 358-366.
2. Dargél AA, Mosconi E, Masson M, Plaze M, Taieb F, Von Platen C, Buivan TP, Pouleriguen G, Sanchez M, Fournier S, Lledo PM et Henry C (2020) Toi Même, a Mobile Health Platform for Measuring Bipolar Illness Activity: Protocol for a Feasibility Study. JMIR Res Protoc. 9(8):e18818.
3. Sarrazin S, Poupon C, Uszynski I, Teillac A, Mangin JF, Polosan M, Favre P, Laidi C, D’Albis MA, Leboyer M, Lledo PM, Henry C, Emsell L, Shakeel MK, Goghari VM et Houenou J. (2020) Neuroimaging Evidence for Increased Neurite Density in Patients Taking Lithium: A Replication Study. Psychother Psychosom. May 8, 1-2.
4. Henry C, Meyrel M, Bigot M, Alonso M, Lledo PM et Dargél AA (2020) Can olfactory dysfunction be a marker of trait or states of bipolar disorders? A comprehensive review. J Affect Disord. 266, 498-502.
5. Collea R, Lazarini F, Verstuyft C, El Asmara K, Lledo PM, Durona E, Rotenberg S, Costemale-Lacoste JF, David DJ, Gressier F, Gardier AM, Hummel T, Becquemont L et Corruble E (2020) The olfactory deficits of depressed patients are restored after remission with venlafaxine treatment. Psychological Medicine 22, 1-9.
6. Chevalier G, Siopi E, Guenin-Macé L, Pascal M, Laval T, Rifflet A, Gomperts Boneca I, Demangel C, Leulier F, Lepousez G, Eberl G et Lledo PM (2020) The impact of gut microbiota on depressive-like behaviors and adult hippocampal neurogenesis requires the endocannabinoid system. Nature Communication 11, 6363.
7. Siopi E, Chevalier G, Katsimpardi L, Saha S, Bigot M, Moigneu C, Eberl G et Lledo PM (2020) Changes in gut microbiota by chronic stress impair the efficacy of fluoxetine. Cell Report 30, 3682-3690.
8. Katsimpardi L, Kuperwasser N, Camus C, Moigneu C, Chiche A, Tolle V, Li H, Kokovay E et Lledo P-M (2019). Systemic GDF11 stimulates the secretion of adiponectin and induces a calorie restriction-like phenotype in aged mice. Aging Cell e13038. doi: 10.1111/acel.13038.
9. Wagner S, Lledo P-M et Lazarini F. (2019). Assessing Olfaction Using Ultrasonic Vocalization Recordings in Mouse Pups with a Sono-olfactometer. Bio-protocol9(4), e3170.
10. Lannuzel A et al. (2019). Long-term outcome in neuroZika: When biological diagnosis matters. Neurology 92, e2406-e2420.
11. Sarrazin S, Poupon C, Teillac A, Mangin JF, Polosan M, Favre P, Laidi C, d’Albis M, Leboyer M, Lledo P-M, Henry C et Houenou J (2019). Higher in vivo Cortical Intracellular Volume Fraction Associated with Lithium Therapy in Bipolar Disorder: A Multicenter NODDI Study. Psychother Psychosom 5, 1-6.
12. Lazarini F, Katsimpardi L, Levivien S, Wagner S, Gressens P, Teissier N et Lledo P-M. (2018). Congenital cytomegalovirus infection alters olfaction before hearing deterioration in mice. J Neurosci. 38, 10424-10437.
13. Thion MS, Low D, Silvin A, Chen J, Grisel P, Schulte-Schrepping J, Blecher R, Ulas T, Squarzoni P, Hoeffel G, Coulpier F, Siopi E, David FS, Scholz C, Shihui F, Lum J, Amoyo AA, Larbi A, Poidinger M, Buttgereit A, Lledo P-M, Greter M, Chan JKY, Amit I, Beyer M, Schultze JL, Schlitzer A, Pettersson S, Ginhoux F, Garel S. (2018). Microbiome influences prenatal and adult microglia in a sex-specific manner. Cell 172(3), 500-516.
14. Sailor KA et Lledo P-M (2018). Youth comes but once in a lifetime for adult-born neurons. Trends in Neurosciences 41, 563-565.
15. Katsimpardi L et Lledo P-M. (2018). Regulation of neurogenesis in the adult and aging brain. Current Opinion in Neurobiology 53, 131–138.
16. Grelat A, Benoit L, Wagner S, Moigneu C, Lledo P-M* et Alonso M* (2018). Adult-born neurons boost odor-reward association. Proc. Natl. Acad. Sci. 115, 2514-2519 (*co-senior authors).
17. Sailor KA, Schinder AF et Lledo P-M (2017). Adult neurogenesis beyond the niche: its potential for driving brain plasticity. Curr. Opin. Neurobiol. 42, 111-117.
18. Denizet M, Cotter L, Lledo P-M et Lazarini F (2017). Sensory deprivation increases phagocytosis of adult-born neurons by activated microglia in the olfactory bulb. Brain Behav and Immunity 60, 38-43.
19. Mazo C, Lepousez G, Nissant A, Valley MT et Lledo P-M (2016). GABA_b receptors tune cortical feedback to the olfactory bulb. J Neurosci. 36(32), 8289–8304.
20. Sailor KA, Valley MT, Wiechert MT, Riecke H, Sun GJ, Dennis JC, Sharafi S, Ming G-L, Song H et Lledo P-M (2016). Persistent structural plasticity optimizes sensory information processing in the olfactory bulb. Neuron 91, 1-13.
21. Lledo P-M et Valley M (2016). Adult Olfactory Bulb Neurogenesis. Cold Spring Harb Perspect Biol. 2016 May 27. pii: a018945. doi: 10.1101/cshperspect.a018945.
22. Grimaud J et Lledo P-M. (2016). Illuminating odors : When optogenetics brings to light  unexpected olfactory abilities. Learn Mem. 23, 249-254.
23. Siopi E, Denizet M, Gabellec M-M, De Chaumont F, Olivo-Marin J-C, Guilloux J-P, Lazarini* et Lledo P-M* (*co-auteurs seniors) (2016). Anxiety- and depression-like states lead to pronounced olfactory deficits and impaired adult neurogenesis in mice. J. Neurosci. 36, 518-531.
24. Cuccioli V, Belvindrah R, Lledo P-M et Martinez S. (2015). Attractive function of FGF-signaling contributes to the postnatal developing hippocampus. Hippocampus 25, 486-499.
25. Lepousez G, Nissant A et Lledo P-M. (2015). Adult neurogenesis and the future of the rejuvenating brain circuits. Neuron 86, 387-401.
26. Lazarini F, Gabellec M-M, Moigneu C et Lledo P-M (2014). Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb. J. Neurosci. 34, 14430-14442.
27. Sailor KA et Lledo P-M. (2014). Top-down modulation of interneuron survival in the olfactory bulb (Commentary on Komano-Inoue et al. Eur J Neurosci. 40, 2014). Eur. J. Neurosci. 40, 2723-2724.
28. Lepousez G, Nissant A, Bryant AK, Gheusi G, Greer CA et Lledo P-M. (2014). Olfactory learning promotes input-specific synaptic plasticity in a adult-born neurons. Proc. Natl. Acad. Sci. 111, 13984 -13989.
29. Gheusi G et Lledo P-M (2014). Adult neurogenesis in the olfactory system shapes odor memory and perception. Brain Res. 208, 157-175.
30. Soria-Gómez E, et coll. (2014). The endocannabinoid system controls food intake via olfactory processes. Nat. Neurosci. 17, 407-415.
31. Khodosevich K, Lazarini F, Kaneko H, Lledo PM et Monyer H (2013). Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb. Neuron 79, 1136-1151.
32. Lepousez G et Lledo P-M. (2013). Odor discrimination requires proper olfactory fast oscillations in awake mice. Neuron 80, 1010-1024.
33. Valley M, Henderson LG, Inverso SA et Lledo P-M. (2013). Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb. J. Neurosci., 33, 14660-14665.
34. Lepousez G, Valley M et Lledo P-M. (2013). Adult neurogenesis in olfactory processing. Annual Review of Physiology 75, 339-363.