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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Molecular and cellular neurosciences

Operative list of genes associated with autism and neurodevelopmental disorders based on database review.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular and cellular neurosciences - 01 Jun 2021

Leblond CS, Le TL, Malesys S, Cliquet F, Tabet AC, Delorme R, Rolland T, Bourgeron T,

Link to Pubmed [PMID] – 33932580

Link to DOI – S1044-7431(21)00036-110.1016/j.mcn.2021.103623

Mol Cell Neurosci 2021 Jun; 113(): 103623

The genetics of neurodevelopmental disorders (NDD) has made tremendous progress during the last few decades with the identification of more than 1,500 genes associated with conditions such as intellectual disability and autism. The functional roles of these genes are currently studied to uncover the biological mechanisms influencing the clinical outcome of the mutation carriers. To integrate the data, several databases and curated gene lists have been generated. Here, we provide an overview of the main databases focusing on the genetics of NDD, that are widely used by the medical and scientific communities, and extract a list of high confidence NDD genes (HC-NDD). This gene set can be used as a first filter for interpreting large scale omics dataset or for diagnostic purposes. Overall HC-NDD genes (N = 1,586) are expressed at very early stages of fetal brain development and enriched in several biological pathways such as chromosome organization, cell cycle, metabolism and synaptic function. Among those HC-NDD genes, 204 (12,9%) are listed in the synaptic gene ontology SynGO and are enriched in genes expressed after birth in the cerebellum and the cortex of the human brain. Finally, we point at several limitations regarding the relatively poor standardized information available, especially on the carriers of the mutations. Progress on the phenotypic characterization and genetic profiling of the carriers will be crucial to improve our knowledge on the biological mechanisms and on risk and protective factors for NDD.

https://pubmed.ncbi.nlm.nih.gov/33932580