My research involves developping innovative and systematic computational approaches to analyze genomics and proteomics data of increasing quantity and quality. My goal is to characterize the mechanisms by which genomes, proteomes and interactomes evolve and how their perturbation can lead to different cellular states. In Prof. Bourgeron’s lab, I study the human protein interaction network to characterize complex genotype-phenotype relationships in the context of autism spectrum disorders. You can find more information on My Research Portal.
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2018Cerebellar Volume in Autism: Literature Meta-analysis and Analysis of the Autism Brain Imaging Data Exchange Cohort., Biol Psychiatry 2018 04; 83(7): 579-588.
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2017A framework to identify contributing genes in patients with Phelan-McDermid syndrome., NPJ Genom Med 2017 ; 2(): 32.
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2016CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders, Mol. Psychiatry 2017 04;22(4):625-633.
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2016An inter-species protein-protein interaction network across vast evolutionary distance, Mol. Syst. Biol. 2016;12(4):865.
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2015Genome-wide replication landscape of Candida glabrata, BMC Biol. 2015 Sep;13:69.
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2015Protein domain-level landscape of cancer-type-specific somatic mutations, PLoS Comput. Biol. 2015 Mar;11(3):e1004147.
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2014A proteome-scale map of the human interactome network, Cell 2014 Nov;159(5):1212-26.
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2014A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease, Cell Rep 2014 Nov;9(3):1135-50.
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2014Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage, Genes Dev. 2014 Sep;28(17):1957-75.
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2013Exploration of binary virus-host interactions using an infectious protein complementation assay, Mol. Cell Proteomics 2013 Oct;12(10):2845-55.
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