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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.

About

My research involves developping innovative and systematic computational approaches to analyze genomics and proteomics data of increasing quantity and quality. My goal is to characterize the mechanisms by which genomes, proteomes and interactomes evolve and how their perturbation can lead to different cellular states. In Prof. Bourgeron’s lab, I study the human protein interaction network to characterize complex genotype-phenotype relationships in the context of autism spectrum disorders. You can find more information on My Research Portal.

Projects

Project
Ongoing
9 Members

Étude des facteurs génétiques impliqués dans l’autisme et les troubles apparentés (projet “C07/C16”)

Richard Delorme (PI)

Sorry, this entry is only available in FR.
Project
Ongoing
11 Members

PARIS: Paris Autism Research International Sib-Pair Study

Thomas Bourgeron (PI)

The Paris Autism Research International Sib-pair (PARIS) Study has been launched as a collaborative project by Prof. M. Leboyer (Paris) and Prof. C. Gillberg (Göteborg) in the 2000s. Its main goal is to join […]
Project
Ongoing
13 Members

EU-AIMS

Thomas Bourgeron (PI)

Around 1% of children are diagnosed with autism spectrum disorders (ASD), yet there are currently no drugs designed specifically to treat their main symptoms. Working to change this is the IMI-funded EU-AIMS project. The […]
Project
Ongoing
18 Members

Background on the genetics of ASD

Thomas Bourgeron (PI)

Autism spectrum disorders (ASD) are a heterogeneous group of pervasive neurodevelopmental disorders affecting approximately 1% of the population. The diagnosis of ASD is based on impairments in reciprocal social communication and stereotyped behaviors. Behind […]
Project
Ongoing
2 Members

Protected: Risk and Resilience in Neuropsychiatry

Thomas Bourgeron (PI)

There is no excerpt because this is a protected post.
Project
Ongoing
15 Members

Phelan-McDermid Syndrome: from mechanisms to treatments

Thomas Bourgeron (PI)

Our team identified the first mutations in the SHANK3 gene, showing it’s role in autism and Phelan-McDermid Syndrome (PMS). Thanks to a donation from the French Association of Phelan-McDermid Syndrome, we will continue the […]
Project
Ongoing
8 Members

The serotonin-NAS-melatonin pathway and susceptibility to ASD

Thomas Bourgeron (PI)

Sleep difficulties are a major concern for families with ASD, but are often considered as an epiphenomenon, and therefore do not catch the attention of the medical and scientific community. In 2008, we reported […]

Tools

Tool
Ongoing
4 Members

GeneTrek

Thomas Bourgeron (PI)

GeneTrek is an online tool that enables users to explore the association of human genes to neurodevelopmental disorders. Users can explore their own gene list or any of the curated gene list. Once queried, […]
Tool
Ongoing
2 Members

Brain protein-protein interactions visualizer

Thomas Bourgeron (PI)

This tool allows you to visualize protein-protein interactions at different developmental periods and in different regions of the human brain : http://ppiviz.pasteur.fr/

Publications

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