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© Therese Couderc, Marc Lecuit
Project

Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
09
Sep 2015
Status
Ongoing
Members
4
Structures
1

About

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria monocytogenes (Lm), is a Gram-positive, environmentally ubiquitous bacterium that can breach intestinal, blood-brain and placental barriers. The clinical course of listeriosis has initially no specific symptoms until Lm reaches the central nervous system and/or the fetal-placental barrier. Thus Lm induces little inflammation in the host, either at the intestinal level or systemically. Proposing that anti-inflammatory responses mediated by bacterial factors are an essential component of Lm’s disease-causing potential, the project seeks to identify and characterize the bacterial factors that cause the suppression of the clinical symptoms of listeriosis.

PROANTILIS is an Infect-ERA project, an ERA-NET on human infectious diseases which is a continuation of PathoGenoMics.

Partners:

  • Trinad Chakraborty (Germany), coordinator
  • Pascale Cossart (France)
  • Marc Lecuit (France)
  • Didier Cabanes (Portugal)
  • Anat Herkovits (Israel)

 

Fundings