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  • center
  • program_project
  • nrc
  • whocc
  • project
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  • tool
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  • Assistant Professor
  • Associate Professor
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  • Clinical Research Nurse
  • Clinician Researcher
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  • Lab assistant
  • Master Student
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  • Pharmacist
  • PhD Student
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  • Post-doc
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  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
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Published in Cell reports. Medicine - 18 Jul 2023

Charlier C, Noel C, Hafner L, Moura A, Mathiaud C, Pitsch A, Meziane C, Jolly-Sanchez L, de Pontfarcy A, Diamantis S, Bracq-Dieye H, Disson O, Thouvenot P, Valès G, Tessaud-Rita N, Tourdjman M, Leclercq A, Lecuit M

Link to Pubmed [PMID] – 37385252

Link to DOI – 10.1016/j.xcrm.2023.101094

Cell Rep Med 2023 Jul; 4(7): 101094

We report a case of fulminant fatal neonatal listeriosis due to horizontal transmission of Listeria monocytogenes (Lm) in a neonatal double room. Genomic analyses reveal a close genetic relationship between clinical isolates, supporting cross-contamination. Oral inoculation experiments in adult and neonatal mice show that neonates are susceptible to a low Lm inoculum and that this susceptibility results from the immaturity of the neonatal gut microbiota. Infected neonates should therefore be isolated for as long as they shed Lm in their feces to avoid horizontal transmission and its dire consequences.