Dr Sáez-Cirión received his PhD in Science in 2001 from the University of the Basque Country, Leioa, Spain. He joined the Institut Pasteur in Paris as a Postdoc in 2003 after a first postdoctoral period at the FDA-CBER in Bethesda. He leads now a research team in the HIV Inflammation and Persistence Unit. His research is currently focused in understanding (i) the mechanisms underlying control of HIV infection in natural HIV controllers and post-treatment controllers in remission of HIV infection after interruption of antiretroviral treatment; (ii) the factors associated with the establishment of HIV reservoirs and devising new approaches to tackle them.
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Timeline
Events
GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”
Building: Lwoff – Room: Room 14 , ground floor – Address: Institut Pasteur, Rue du Docteur Roux, Paris, France
2017-04-18 16:00:00
2017-04-18 18:00:00
Europe/Paris
GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”
Speakers : Romulus BREBAN, Jade GHOSN , Nathalie DEJUCQ —————- Romulus BREBAN Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris Meta-analysis of the residual risk of sexual HIV transmission from efficiently treated persons […]
Institut Pasteur, Rue du Docteur Roux, Paris, France
Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”
Building: Lwoff – Room: 14 RdC – Address: 28 Rue du Dr Roux, 75015 Paris, France
2017-11-21 16:00:00
2017-11-21 18:00:00
Europe/Paris
Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”
Organizer: Lisa CHAKRABARTI, for the GRS organization committee Unité de Pathogénie Virale, Institut Pasteur, Paris Speakers : Frédéric TANGY Unité de Génomique Virale et Vaccination, Institut Pasteur, Paris Protective efficacy of live measles-HIV vaccine […]
28 Rue du Dr Roux, 75015 Paris, France
Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”
Building: Lwoff – Room: 14 RdC – Address: 28 Rue du Dr Roux, Paris, France
2018-02-16 16:00:00
2018-02-16 18:00:00
Europe/Paris
Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”
Organizer : Asier SAEZ-CIRION, for the GRS organization committee Unité HIV, Inflammation, et Persistance, Institut Pasteur, Paris Speakers : Mireille LAFORGE UFR Biomédicale, Université Paris Descartes Impact de la morphogenèse mitochondriale sur le métabolisme […]
28 Rue du Dr Roux, Paris, France
GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”
Address: 25 Rue du Dr Roux, 75015 Paris, France
2018-03-13 16:00:00
2018-03-13 18:00:00
Europe/Paris
GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”
Organizer : Jade GHOSN UF de Thérapeutique en Immuno-Infectiologie, Hôtel Dieu, Paris Speakers : Dominique COSTAGLIOLA INSERM, Sorbonne Université, Institut Pierre Louis d’Epidémiologie et de Santé Publique, Paris Restauration immunitaire chez les PVVIH initiant […]
25 Rue du Dr Roux, 75015 Paris, France
Projects
CV
RESEARCH POSITIONS
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2018-present |
Associat Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
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2014-2017 |
Assistant Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
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2010-2014 |
Assistant Professor in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
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2007-2009 |
Senior Scientist in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
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2003-2007 |
Postdoctoral position in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. Research advisor: Dr. Gianfranco Pancino. Project: Mechanism of resistance to HIV-1 infection in human primary cells. |
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2002-2003 |
Postdoctoral position in the Division of Viral Products, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda MD, USA. Research advisor: Dr. Carol D. Weiss. Project: Rational approaches to block HIV entry. |
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1998-2001 |
PhD student in the Unidad de Biofisica (CSIC-UPV/EHU), Department of Biochemistry, University of the Basque Country, Leioa, Spain. Research advisor: Prof. J.L. Nieva. Project: Mechanisms of virus-induced membrane fusion. |
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1995-1998 |
Undergraduate Student in the Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain. Research advisors: Prof. A. Alonso and Prof. E. A. Rivas. Projects: Effects of lipids in membrane fusion and Effects of surfactants in the different phases of lipids on model membranes. |
ACADEMIC QUALIFICATION
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2013 |
HDR in Life Sciences, Université Pierre et Marie Curie, Paris VI, Paris, France. |
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2001 |
PhD in Biochemistry and Molecular Biology, University of the Basque Country, Leioa, Spain. “Membrane interacting domains in virus and prions”. Suma Cum Laude. |
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2000 |
MSc degree, in Biochemistry. University of the Basque Country, Leioa, Spain. |
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1998 |
Graduated in Biochemistry, University of the Basque Country, Leioa, Spain. |
SOME ADDITIONAL PROFESSIONAL RESPONSABILITIES
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2017-present |
President of Scientific and Medical Committee of SIDACTION |
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2014-present |
Coordinator of the ANRS RHIVIERA consortium on HIV remission |
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2013-present |
Coordinator of the ANRS International Post-Treatment Controllers cohort |
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2013-present |
Member of the Scientific and Medical Committee of SIDACTION |
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2012-present |
Member of the Scientific Committee of CO6 ANRS PRIMO cohort |
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2012-present |
Member of Institut Pasteur’s Groupe de Réflexion sur le SIDA (GRS) |
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2012-present |
Member of the Steering Committee of CO21 ANRS CODEX cohort |
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2011-2017 |
Co-president of the ANRS coordinated action AC32 “HIV reservoirs” |
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2010-2017 |
Elected Member of Institut Pasteur’s Virology Department Council |
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Publications
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2018Immune Responses to Retroviruses, Annu. Rev. Immunol. 2018 Jan;.
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2017Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities, PLoS ONE 2017;12(10):e0184496.
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2017p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity, J. Virol. 2017 Dec;91(23).
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2017HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION, J. Virol. 2017 Sep;.
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2017Clinical and public health implications of acute and early HIV detection and treatment: a scoping review, J Int AIDS Soc 2017 Jun;20(1):1-13.
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2017A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level, Open Forum Infect Dis 2017;4(2):ofx064.
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2017Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents, J. Virol. 2017 03;91(6).
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2016Polyfunctional HIV-specific T cells in Post-Treatment Controllers, AIDS 2016 Sep;30(15):2299-302.
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2016Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers, J. Immunol. 2016 Aug;.
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2016Strong Ifitm1 Expression In Cd4 T Cells In Hiv Controllers Is Correlated With Immune Activation, J. Acquir. Immune Defic. Syndr. 2016 Aug;.
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