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© Charles Dauguet
Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.
Bluesky Logo @asiersc.bsky.social (July 9, 2025, 8:28 am)

"We are at a dangerous crossroads. While scientific breakthroughs bring us closer to a cure, these advances are now at risk... Massive cuts threaten to slow or even undo decades of hard-won progress.” -IAS President Beatriz Grinsztejn, #IAS2025

About

Dr Sáez-Cirión received his PhD in Science in 2001 from the University of the Basque Country, Leioa, Spain. He joined the Institut Pasteur in Paris as a Postdoc in 2003 after a first postdoctoral period at the FDA-CBER in Bethesda. He leads now  the Viral Reservoirs and Immune Control Unit. His research is currently focused in understanding (i) the mechanisms underlying control of HIV infection in natural HIV controllers and post-treatment controllers in remission of HIV infection after interruption of antiretroviral treatment; (ii) the factors associated with the establishment of HIV reservoirs and devising new approaches to tackle them.

Courses

09:00
14
Nov 2023
Course

HIV Science MOOC

In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]
HIV, Inflammation and Viral Persistences
Virus HIV1
Virology
Immunology
Michaela Muller-Trutwin
Asier Sáez-Cirión
Aurelio Orta-Resendiz
2023-11-14 09:00:00 2024-01-31 22:00:00 Europe/Paris HIV Science MOOC In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]

Projects

Project
Not started
6 Members

Rôle des cellules immunitaires dénommées “Natural Killer” au cours de l’infection par le virus de l’immunodéficience humaine : HICONK (2024-050) 

Asier Sáez-Cirión (PI)

L’objectif de cette demande est de décrire les modifications observées des cellules NK lors du processus d’éducation.   Quelles données personnelles et quels échantillons collectés auprès des participants sont utilisés, et quelles analyses sont […]
Project
Ongoing
2 Members

Humoral immunity in HIV-1 post-treatment controllers

Hugo Mouquet (PI)

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers HIV-1 post-treatment controllers (PTC) are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control […]
Project
Not started
3 Members

ANRS-12414-PediacamNeg

Florence Buseyne (PI)

The ANRS 12225-Pediacam study is coordinated by Mr. Tejiokem at the Center Pasteur in Cameroon. Since 2007, the project has included children exposed or infected with HIV-1 and a group of unexposed and uninfected […]
Project
Ongoing
7 Members

Archive of the Group for AIDS Research

Lisa Chakrabarti (PI)

This page contains the list of past meetings held by the Group for AIDS Research (Groupe de Réflexion SIDA) of the Pasteur Institute since 2014. The list of previous meetings held since 2002 can […]
Project
Ongoing
11 Members

Group for AIDS Research

Nicoletta Casartelli (PI)

The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. Meetings […]
Project
Ongoing
3 Members

ICISTEM-International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation

Javier Martinez-Picado (PI)

ICISTEM is a collaborative project to guide and investigate the potential for HIV cure in HIV-infected patients requiring allogeneic stem cell transplantation for hematological disorders. The ICIISTEM consortium is composed of an expert European […]
Project
Ongoing
4 Members

Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)

Florence Buseyne (PI)

A  collaborative study with members of Pasteur Institute (A. Saez-Cirion, D. Scott-Algara), french perinatal cohort (ANRS CO10; J. Warszawsky) and 10 hospitals from Paris Area (Principal investigator, P. Frange). The study has included 76 […]
Project
Ongoing
3 Members

Natural Control of HIV-1 Infection

Asier Sáez-Cirión (PI)

HIV-controllers (HIC) (also called “elite controllers” or “elite suppressors”) are rare (less than 1%) persons living with HIV who control viral replication to undetectable levels in the absence of antiretroviral treatment. In the context […]
Project
Ongoing
4 Members

Role of CD8 T cells responses in the control of HIV-2 infection-ANRS Immunovir2

Asier Sáez-Cirión (PI)

The number of persons living with HIV-1 is around 35 million while roughly one million persons are living with HIV-2, with a decreasing prevalence. Both HIV-1 and HIV-2 are associated with AIDS, however most HIV-2 […]

CV

RESEARCH POSITIONS
2023-current Associate Professor and Head of the Viral Reservoirs and Immune Control Unit, Institut Pasteur, Paris, France.
2018-2022 Associate Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France.
2014-2017 Assistant Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France.
2010-2014 Assistant Professor in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.
2007-2009 Senior Scientist in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France.
2003-2007 Postdoctoral position in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. Research advisor: Dr. Gianfranco Pancino. Project: Mechanism of resistance to HIV-1 infection in human primary cells.
2002-2003 Postdoctoral position in the Division of Viral Products, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda MD, USA. Research advisor: Dr. Carol D. Weiss. Project: Rational approaches to block HIV entry.
1998-2001 PhD student in the Unidad de Biofisica (CSIC-UPV/EHU), Department of Biochemistry, University of the Basque Country, Leioa, Spain. Research advisor: Prof. J.L. Nieva. Project: Mechanisms of virus-induced membrane fusion.
1995-1998 Undergraduate Student in the Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain. Research advisors: Prof. A. Alonso and Prof. E. A. Rivas. Projects: Effects of lipids in membrane fusion and Effects of surfactants in the different phases of lipids on model membranes.
ACADEMIC QUALIFICATION
2013 HDR in Life Sciences, Université Pierre et Marie Curie, Paris VI, Paris, France.
2001 PhD in Biochemistry and Molecular Biology, University of the Basque Country, Leioa, Spain. “Membrane interacting domains in virus and prions”. Suma Cum Laude.
2000 MSc degree, in Biochemistry. University of the Basque Country, Leioa, Spain.
1998 Graduated in Biochemistry, University of the Basque Country, Leioa, Spain.
SOME ADDITIONAL PROFESSIONAL RESPONSABILITIES
2017-present  President of Scientific and Medical Committee of SIDACTION
2014-present Coordinator of the ANRS RHIVIERA consortium on HIV remission
2013-present Coordinator of the ANRS International Post-Treatment Controllers cohort
2013-present Member of the Scientific and Medical Committee of SIDACTION
2012-present Member of the Scientific Committee of CO6 ANRS PRIMO cohort
2012-present Member of Institut Pasteur’s Groupe de Réflexion sur le SIDA (GRS)
2012-present Member of the Steering Committee of CO21 ANRS CODEX cohort
2011-2017 Co-president of the ANRS coordinated action AC32 “HIV reservoirs”
2010-2017 Elected Member of Institut Pasteur’s Virology Department Council

Publications

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