Dr Sáez-Cirión received his PhD in Science in 2001 from the University of the Basque Country, Leioa, Spain. He joined the Institut Pasteur in Paris as a Postdoc in 2003 after a first postdoctoral period at the FDA-CBER in Bethesda. He leads now the Viral Reservoirs and Immune Control Unit. His research is currently focused in understanding (i) the mechanisms underlying control of HIV infection in natural HIV controllers and post-treatment controllers in remission of HIV infection after interruption of antiretroviral treatment; (ii) the factors associated with the establishment of HIV reservoirs and devising new approaches to tackle them.
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About
Courses
HIV Science MOOC
In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. Register on: https://www.fun-mooc.fr/en/courses/hiv-science/ Flyer: MOOC_VIH_2022 […]
2022-03-15 09:00:00
2022-05-10 22:00:00
Europe/Paris
HIV Science MOOC
In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. Register on: https://www.fun-mooc.fr/en/courses/hiv-science/ Flyer: MOOC_VIH_2022 […]
Projects
CV
RESEARCH POSITIONS
| 2023-current | Associate Professor and Head of the Viral Reservoirs and Immune Control Unit, Institut Pasteur, Paris, France. |
| 2018-2022 | Associate Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
| 2014-2017 | Assistant Professor and Team Leader in the Unité HIV inflammation et persistance, Institut Pasteur, Paris, France. |
| 2010-2014 | Assistant Professor in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
| 2007-2009 | Senior Scientist in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. |
| 2003-2007 | Postdoctoral position in the Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France. Research advisor: Dr. Gianfranco Pancino. Project: Mechanism of resistance to HIV-1 infection in human primary cells. |
| 2002-2003 | Postdoctoral position in the Division of Viral Products, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Bethesda MD, USA. Research advisor: Dr. Carol D. Weiss. Project: Rational approaches to block HIV entry. |
| 1998-2001 | PhD student in the Unidad de Biofisica (CSIC-UPV/EHU), Department of Biochemistry, University of the Basque Country, Leioa, Spain. Research advisor: Prof. J.L. Nieva. Project: Mechanisms of virus-induced membrane fusion. |
| 1995-1998 | Undergraduate Student in the Unidad de Biofísica (CSIC-UPV/EHU), University of the Basque Country, Leioa, Spain. Research advisors: Prof. A. Alonso and Prof. E. A. Rivas. Projects: Effects of lipids in membrane fusion and Effects of surfactants in the different phases of lipids on model membranes. |
ACADEMIC QUALIFICATION
| 2013 | HDR in Life Sciences, Université Pierre et Marie Curie, Paris VI, Paris, France. |
| 2001 | PhD in Biochemistry and Molecular Biology, University of the Basque Country, Leioa, Spain. “Membrane interacting domains in virus and prions”. Suma Cum Laude. |
| 2000 | MSc degree, in Biochemistry. University of the Basque Country, Leioa, Spain. |
| 1998 | Graduated in Biochemistry, University of the Basque Country, Leioa, Spain. |
SOME ADDITIONAL PROFESSIONAL RESPONSABILITIES
| 2017-present | President of Scientific and Medical Committee of SIDACTION | ||
| 2014-present | Coordinator of the ANRS RHIVIERA consortium on HIV remission | ||
| 2013-present | Coordinator of the ANRS International Post-Treatment Controllers cohort | ||
| 2013-present | Member of the Scientific and Medical Committee of SIDACTION | ||
| 2012-present | Member of the Scientific Committee of CO6 ANRS PRIMO cohort | ||
| 2012-present | Member of Institut Pasteur’s Groupe de Réflexion sur le SIDA (GRS) | ||
| 2012-present | Member of the Steering Committee of CO21 ANRS CODEX cohort | ||
| 2011-2017 | Co-president of the ANRS coordinated action AC32 “HIV reservoirs” | ||
| 2010-2017 | Elected Member of Institut Pasteur’s Virology Department Council | ||
Publications
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2022Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells., Viruses 2022 09; 14(9): .
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2022NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections., Commun Biol 2022 Jul; 5(1): 674.
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2022Novel role of UHRF1 in the epigenetic repression of the latent HIV-1., EBioMedicine 2022 Apr; 79(): 103985.
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2022Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers., Nat Commun 2022 Apr; 13(1): 1944.
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2022Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control., J Clin Invest 2022 06; 132(11): .
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2022Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function., Front Immunol 2022 ; 13(): 781356.
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2021Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort., EClinicalMedicine 2021 Jul; 37(): 100963.
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2021Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection., J Virol 2021 06; 95(14): e0001621.
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2021SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity., Nat Commun 2021 02; 12(1): 1282.
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2021Immunometabolism and HIV-1 pathogenesis: food for thought., Nat. Rev. Immunol. 2021 Jan;21(1):5-19.
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