Michaela Müller-Trutwin studied Biology at the University in Bonn and Frankfurt, Germany. She obtained her PhD from Paris University, France in the Barré-Sinoussi lab. She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui and Dakar as well as at the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. In 2009, she obtained the position of Associate Professor at Institut Pasteur. In 2014 she was appointed head of the Unit “HIV, Inflammation and Persistence”. As Dean, she was directing the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. Among other duties, she serves as a Steering Committee member of the Center for Innovative Therapies for infectious Disease models (IDMIT). Her research contributed to the discovery of several HIV and SIV viruses, such as the 1st SIV from African green monkeys in Central Africa and the first SIV from chimpanzees in Cameroon as well as to the demonstration of the expansion of HIV-1 subtype A in Central African Republic at the expense of other HIV-1 subtypes. Her work was instrumental for the development of tools allowing the study of African monkeys as models for protection against AIDS. Her work delivered the first indirect indication that natural hosts of SIV are protected against AIDS without controlling viral replication. Her team discovered that the lack of AIDS in the natural hosts of SIV is associated with a rapid control of inflammation. Today, the lab is focused on deciphering the early host immune responses to identify factors involved in the protection against chronic inflammation and control of viral reservoirs in SIV and HIV-1 infections with the aim to translate the findings into clinical HIV research. Her work has been honored for instance by the French Medical Research Award and the Pasteur Vallery Radot award.
NK cells and viral reservoirs
The goal of the vaccine research institute (VRI) is to conduct research to boost the development of a vaccine against HIV-AIDS and hepatitis C. Its scope is broad thanks to three developments: so-called innovative […]
European Network on Myeloid Regulatory Cells
In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase […]
A model of control of chronic inflammation
Chronic immune activation during HIV infection is considered as the driving force of CD4+ T cell depletion and AIDS. In cART-treated patients, a residual systemic immune activation persists. It is this chronic low level […]
Puyoo Award: http://www.prixpuyoo.fr/laureat-2016.html
Cut AIDS Short: http://www.acconciatoricontroaids.it/unisciti_a_noi.php
Pasteur Vallery-Radot Award: cp_vallery_radot_2014
CROI 2014, Boston, USA, “Toward a Cure” Symposium: A Challenging Game of Hide and Seek; Inflammation as an Obstacle for Remission: Lessons Learned From Non-Human Primate Models.
Frankfurter Allgemeine Zeitung: FAZ
2017Ancient hybridization and strong adaptation to viruses across African vervet monkey populations, Nat. Genet. 2017 Oct;.
2017Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys, Nat. Med. 2017 Nov;23(11):1277-1286.
2017p21 Restricts HIV-1 in Monocyte-Derived Dendritic Cells through the Reduction of Deoxynucleoside Triphosphate Biosynthesis and Regulation of SAMHD1 Antiviral Activity, J. Virol. 2017 Dec;91(23).
2017High proportion of PD-1-expressing CD4(+) T cells in adipose tissue constitutes an immunomodulatory microenvironment that may support HIV persistence, Eur. J. Immunol. 2017 Aug;.
2017Impact of early cART on HIV blood and semen compartments at the time of primary infection, PLoS ONE 2017;12(7):e0180191.
2017NKG2C(+) memory-like NK cells contribute to the control of HIV viremia during primary infection: Optiprim-ANRS 147, Clin Transl Immunology 2017 Jul;6(7):e150.
2017Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents, J. Virol. 2017 03;91(6).
2017A Mature NK Profile at the Time of HIV Primary Infection Is Associated with an Early Response to cART, Front Immunol 2017;8:54.
2017CXCR6-Mediated Simian Immunodeficiency Virus SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections, J. Virol. 2017 Feb;91(4).
2016Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset, PLoS Pathog. 2016 Aug;12(8):e1005774.
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