Michaela Müller-Trutwin is Professor at Institut Pasteur and the head of the “HIV, Inflammation and Persistence” Unit. She studied Biology at the University in Bonn, Germany and Frankfurt, Germany. She obtained her PhD from Paris University, France (Françoise Barré-Sinoussi lab). She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui (Central African Republic), the Institut Pasteur in Dakar (Senegal) and the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. As Dean, she was directing the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. She currently serves as Chair of the national coordinated action on HIV basic research at the ANRS and as Vice-president of the Scientific Council at Institut Pasteur. Among other duties, she is Steering Committee member of the Center for Innovative Therapies for infectious Disease models (IDMIT). Her research contributed to the discovery of several HIV and SIV viruses, such as the 1st SIV from African green monkeys in Central Africa and the first SIV from chimpanzees in Cameroon as well as to the demonstration of the expansion of HIV-1 subtype A (CRF02) in Central African Republic at the expense of other HIV-1 subtypes. Her work was instrumental for the development of tools allowing the study of African monkeys as models for protection against AIDS. Her work delivered the first indirect indication that natural hosts of SIV are protected against AIDS without controlling viral replication. Her team discovered that the lack of AIDS in the natural hosts of SIV is associated with a rapid control of inflammation. They also uncovered a role of NK cells in the control of SIV replication in tissues. Today, the lab is focused on deciphering the early host immune responses to identify factors involved in the protection against chronic inflammation and control of viral reservoirs in SIV and HIV-1 infections with the aim to translate the findings into clinical HIV research. Her work has been honored for instance by the French Medical Research Award and the Pasteur Vallery Radot award.
HIV Science MOOC
In this MOOC we will review different aspects of HIV infection: from its biological origin and its identification as the causative agent of AIDS to the perspectives of eradication. >>Register here<< In this MOOC […]
NK cells and viral reservoirs
Group for AIDS Research
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]
The major goal of the vaccine research institute (VRI) consists in boosting the development of a vaccine against HIV. The VRI is a laboratory of excellence (Labex) created as part of the first PIA […]
European Network on Myeloid Regulatory Cells
In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase […]
A model of control of chronic inflammation
Chronic immune activation during HIV infection is considered as the driving force of CD4+ T cell depletion and AIDS. In cART-treated patients, a residual systemic immune activation persists. It is this chronic low level […]
Michaela Müller-Trutwin studied Biology at the University in Bonn, Germany (Klaus Willecke lab) and Frankfurt, Germany (Helga Rübsamen lab). She obtained her PhD from Paris University, France (Françoise Barré-Sinoussi lab). She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui (Central African Republic), the Institut Pasteur in Dakar (Senegal) and the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. She holds the position of Professor at Institut Pasteur. Since 2014 she is the head of the Unit “HIV, Inflammation and Persistence”. As Dean, she was directing the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. She currently serves as Chair of the national coordinated action on HIV basic research at the ANRS. Among other duties, she is member of the the Scientific Council at Institut Pasteur and of the Steering Committee from the Center for Innovative Therapies for infectious Disease models (IDMIT).
https://www.youtube.com/watch?v=efg2XvBkEZU , IAS 2019 http://www.aidsmap.com/news/jul-2019/could-better-understanding-inflammation-help-research-towards-hiv-cure MEDIA France3The 2017 IAS HIV Cure and Cancer Forum : http://www.aidsmap.com/What-marks-out-HIV-controllers-from-others/page/3162835/ Bremen-01-12-16-Welt-Aids-Tag Interview Pasteur Wien-29-11-16-Aids-Tag Interview Michaela Muller Trutwin Puyoo Award: http://www.prixpuyoo.fr/laureat-2016.html Cut AIDS Short: http://www.acconciatoricontroaids.it/unisciti_a_noi.php REUTERS : http://news.trust.org//item/20151009060306-cd93y/ http://www.rtl.fr/actu/bien-etre/sida-pourquoi-il-n-y-a-pas-encore-de-vaccin-7900012895 ; Pasteur Vallery-Radot Award: cp_vallery_radot_2014 CROI 2014, Boston, USA, “Toward a Cure” Symposium: A Challenging Game of Hide and Seek; Inflammation as an Obstacle for Remission: Lessons Learned From Non-Human Primate Models. http://www.croiwebcasts.org/portal;jsessionid=5A82A2D79E0C3E0E7964DC6CC45F2675 Le-Point Frankfurter Allgemeine Zeitung: FAZ ,
2023SARS-CoV-2 viral persistence in lung alveolar macrophages is controlled by IFN-γ and NK cells., Nat Immunol 2023 Nov; (): .
2022NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections., Commun Biol 2022 Jul; 5(1): 674.
2022CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue., Pathogens 2022 Apr; 11(4): .
2022Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control., J Clin Invest 2022 06; 132(11): .
2021NK-B cell cross talk induces CXCR5 expression on natural killer cells., iScience 2021 Oct; 24(10): 103109.
2021Interests of the Non-Human Primate Models for HIV Cure Research., Vaccines (Basel) 2021 Aug; 9(9): .
2021IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques., Nat Commun 2021 05; 12(1): 2866.
2021Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection., J Virol 2021 06; 95(14): e0001621.
2021HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART., HIV Med 2021 May; 22(5): 397-408.
2021Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections., iScience 2021 Apr; 24(4): 102314.
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