Michaela Müller-Trutwin is Professor at Institut Pasteur and the head of the “HIV, Inflammation and Persistence” Unit. She studied Biology at the University in Bonn, Germany and Frankfurt, Germany. She obtained her PhD from Paris University, France (Françoise Barré-Sinoussi lab). She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui (Central African Republic), the Institut Pasteur in Dakar (Senegal) and the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. As Dean, she was directing the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. She currently serves as Chair of the national coordinated action on HIV basic research at the ANRS and as Vice-president of the Scientific Council at Institut Pasteur. Among other duties, she is Steering Committee member of the Center for Innovative Therapies for infectious Disease models (IDMIT). Her research contributed to the discovery of several HIV and SIV viruses, such as the 1st SIV from African green monkeys in Central Africa and the first SIV from chimpanzees in Cameroon as well as to the demonstration of the expansion of HIV-1 subtype A (CRF02) in Central African Republic at the expense of other HIV-1 subtypes. Her work was instrumental for the development of tools allowing the study of African monkeys as models for protection against AIDS. Her work delivered the first indirect indication that natural hosts of SIV are protected against AIDS without controlling viral replication. Her team discovered that the lack of AIDS in the natural hosts of SIV is associated with a rapid control of inflammation. They also uncovered a role of NK cells in the control of SIV replication in tissues. Today, the lab is focused on deciphering the early host immune responses to identify factors involved in the protection against chronic inflammation and control of viral reservoirs in SIV and HIV-1 infections with the aim to translate the findings into clinical HIV research. Her work has been honored for instance by the French Medical Research Award and the Pasteur Vallery Radot award.
NK cells and viral reservoirs
Group for AIDS Research
The Group for AIDS Research (Groupe de Réflexion SIDA, GRS) organizes bimonthly meetings and seminars around an HIV / AIDS research topic. Since 2021, the meetings may also include topics related to emerging viruses. […]
The major goal of the vaccine research institute (VRI) consists in boosting the development of a vaccine against HIV. The VRI is a laboratory of excellence (Labex) created as part of the first PIA […]
European Network on Myeloid Regulatory Cells
In cancer, infection and inflammation, the immune system’s function can be dysregulated, contributing to disease pathology. As part of this process, instead of fighting disease, immune cells may suppress beneficial immune responses and increase […]
A model of control of chronic inflammation
Chronic immune activation during HIV infection is considered as the driving force of CD4+ T cell depletion and AIDS. In cART-treated patients, a residual systemic immune activation persists. It is this chronic low level […]
Michaela Müller-Trutwin studied Biology at the University in Bonn, Germany (Klaus Willecke lab) and Frankfurt, Germany (Helga Rübsamen lab). She obtained her PhD from Paris University, France (Françoise Barré-Sinoussi lab). She worked at Research Institutes in West- and Central Africa, in particular at the Institut Pasteur in Bangui (Central African Republic), the Institut Pasteur in Dakar (Senegal) and the CIRMF in Gabon and collaborated with the Institut Pasteur in South-East Asia. She holds the position of Professor at Institut Pasteur. Since 2014 she is the head of the Unit “HIV, Inflammation and Persistence”. As Dean, she was directing the Pasteur-Paris University International PhD Program from its beginning in 2008 until 2013. She currently serves as Chair of the national coordinated action on HIV basic research at the ANRS. Among other duties, she is member of the the Scientific Council at Institut Pasteur and of the Steering Committee from the Center for Innovative Therapies for infectious Disease models (IDMIT).
https://www.youtube.com/watch?v=efg2XvBkEZU , IAS 2019 http://www.aidsmap.com/news/jul-2019/could-better-understanding-inflammation-help-research-towards-hiv-cure MEDIA France3The 2017 IAS HIV Cure and Cancer Forum : http://www.aidsmap.com/What-marks-out-HIV-controllers-from-others/page/3162835/ Bremen-01-12-16-Welt-Aids-Tag Interview Pasteur Wien-29-11-16-Aids-Tag Interview Michaela Muller Trutwin Puyoo Award: http://www.prixpuyoo.fr/laureat-2016.html Cut AIDS Short: http://www.acconciatoricontroaids.it/unisciti_a_noi.php REUTERS : http://news.trust.org//item/20151009060306-cd93y/ http://www.rtl.fr/actu/bien-etre/sida-pourquoi-il-n-y-a-pas-encore-de-vaccin-7900012895 ; Pasteur Vallery-Radot Award: cp_vallery_radot_2014 CROI 2014, Boston, USA, “Toward a Cure” Symposium: A Challenging Game of Hide and Seek; Inflammation as an Obstacle for Remission: Lessons Learned From Non-Human Primate Models. http://www.croiwebcasts.org/portal;jsessionid=5A82A2D79E0C3E0E7964DC6CC45F2675 Le-Point Frankfurter Allgemeine Zeitung: FAZ ,
2021Ultrasensitive detection of p24 in plasma samples from people with primary and chronic HIV-1 infection., J Virol 2021 May; (): .
2021HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART., HIV Med 2021 May; 22(5): 397-408.
2021SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity., Nat Commun 2021 02; 12(1): 1282.
2021CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
2020DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4 + T cells in response to SIV infections., Clin Epigenetics 2020 Dec; 12(1): 188.
2020Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study., Cell Rep 2020 09; 32(12): 108174.
2020Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation., J Immunother Cancer 2020 Sep; 8(2): .
2020Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection., J Virol 2020 07; 94(14): .
2020Extremely low viral reservoir in treated chronically HIV-1-infected individuals., EBioMedicine 2020 Jul; 57(): 102830.
2020TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women., JCI Insight 2020 06; 5(12): .
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