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© Michaela Muller-Trutwin
HIV

About

Our research activities are centered on the discovery of mechanisms responsible for the control HIV replication and HIV-induced chronic inflammation

Since the discovery of HIV at the Institut Pasteur, tremendous progress has been made in preventing and treating HIV infection. However, a vaccine and a cure are still missing. Our laboratory aims to discover mechanisms that control HIV infection and HIV-associated disease. Our original approach consists in learning from the efficient control of HIV/AIDS that exists in HIV-infected individuals who control HIV replication, either spontaneously or after an antiretroviral treatment (HIV remission) and in some very rare animal models of spontaneous protection against AIDS. We aim to discover immunological and genetic factors that are responsible for such a protection in vivo. We focus in particular on:

– the early phases of HIV/SIV infection
– the interplay between innate and adaptive immunity
– regulation of HIV infection through metabolic factors

Such insights will allow a better understanding of how these protective mechanisms are induced. Such results might also contribute to a better understanding of the factors regulating the critical balance between helpful inflammation (leading to efficient antiviral immune responses) and harmful inflammation (enhancing infection and disease). On the longer term, the studies shall help to define scalable approaches for a durable HIV remission and contribute to the development of an efficient vaccine against HIV. In addition, the studies are designed to allow for the screening of biomarkers of inflammation and HIV remission, an essential step for clinical management for the patients.

HIPER 2014-2015

Former Members

2000
2000
Name
Position
2015
2017
Kathleen Gartner
Post-doc
2011
2014
Simon Jochems
PhD student
2015
2016
Sylvie Garnero
Administrative Staff
2014
2018
Mickael Ploquin
Post-doc
2017
2018
Alexandra Prost
Administrative Staff
2014
2019
Annie David
Research Engineer
2014
2019
Mathieu Angin
Post-doc
2014
2019
Jose Carlos Valle Casuso
Post-doc
2015
2019
Thalìa Garcìa
PhD Student
2015
2019
Anastassia Mikhailova
PhD Student
2018
2019
Antonia-Maria Schafer
MD, Undergraduate Student
2017
2019
Nicolas Noël
MD, Post-doc
2018
2019
Benedikt Wimmer
Undergraduate Student
2018
2019
Emma Booth
Undergraduate Student
2018
2019
Sophie Benard
Technician
2019
2019
Roseline Affi Mihesse
Scientist
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Contact

Phone:+33145688760 Email: brigitte.bidault@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France