Timeline

Asier Sáez-Cirión
Head of Structure
01 Feb 2024
publication

CD8 + T-cell priming is quantitatively but not qualitatively impaired in people with HIV-1 on antiretroviral therapy.

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11 Jan 2024
publication

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells.

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01 Oct 2023
publication

[A shot of synTac to activate CD8+ T cells cytotoxic specific response against HIV].

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06 Jul 2023
publication

Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller.

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17 May 2023
event

40 years of HIV science

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12 Apr 2023
publication

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection.

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20 Feb 2023
publication

In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation.

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24 Jan 2023
publication

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control.

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01 Jan 2023
publication

Highlights from the Inaugural HIV Reservoirs and Immune Control Conference, October 1st-4th 2023, Malahide Ireland.

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02 Oct 2022
publication

Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.

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17 Sep 2022
publication

Autopsy Study Defines Composition and Dynamics of the HIV-1 Reservoir after Allogeneic Hematopoietic Stem Cell Transplantation with CCR5Δ32/Δ32 Donor Cells.

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07 Jul 2022
publication

NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections.

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13 Apr 2022
publication

Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.

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11 Apr 2022
publication

Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers.

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05 Apr 2022
publication

Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control.

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04 Feb 2022
course

HIV Science MOOC

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01 Jan 2022
publication

Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function.

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01 Jul 2021
publication

Antiretroviral therapy for HIV controllers: Reasons for initiation and outcomes in the French ANRS-CO21 CODEX cohort.

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05 May 2021
publication

Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection.

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18 Apr 2021
project

Humoral immunoprofiling in HIV-1 post-treatment controllers

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24 Feb 2021
publication

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity.

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01 Jan 2021
publication

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.

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01 Jan 2021
publication

Immunometabolism and HIV-1 pathogenesis: food for thought.

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22 Sep 2020
publication

Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study.

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18 Aug 2020
publication

Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments.

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26 Jul 2020
publication

The genome-wide methylation profile of CD4+ T cells from HIV-infected individuals identifies distinct patterns associated with disease progression.

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01 Jul 2020
publication

Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection.

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01 Jul 2020
publication

Extremely low viral reservoir in treated chronically HIV-1-infected individuals.

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08 Jun 2020
publication

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends.

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06 May 2020
publication

Vulnerability to reservoir reseeding due to high immune activation after allogeneic hematopoietic stem cell transplantation in individuals with HIV-1.

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18 Dec 2019
project

ANRS-12414-PediacamNeg

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14 Oct 2019
publication

HIV controllers: to treat or not to treat? Is that the right question?

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02 Aug 2019
publication

The proportion of CD57+ cells among effector CD8+ T cells is lower HIV controllers compared to ART treated patients

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01 Jul 2019
publication

Metabolic plasticity of HIV-specific CD8+ T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection.

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01 Jun 2019
publication

The Yellow Brick Road towards HIV Eradication.

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10 May 2019
event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of HIV antigen presentation”

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01 May 2019
publication

HIV Controllers Have Low Inflammation Associated with a Strong HIV-Specific Immune Response in Blood

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08 Apr 2019
event

Groupe de Reflexion SIDA (GRS) seminar: “Determinants of HIV-1 broadly neutralizing antibody induction”

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05 Mar 2019
publication

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4+ T Cells and Offers an Opportunity to Tackle Infection.

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04 Mar 2019
event

Groupe de Réflexion SIDA (GRS) meeting: “Mechanisms of restriction of viral entry”

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26 Feb 2019
publication

Safety of CD34 Hematopoietic Stem Cells and CD4 T Lymphocytes Transduced with LVsh5/C46 in HIV-1 Infected Patients with High-Risk Lymphoma

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31 Jan 2019
project

Archive of the Group for AIDS Research

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01 Jan 2019
publication

Dynamics in HIV-DNA levels over time in HIV controllers

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21 Nov 2018
event

Groupe de Reflexion SIDA (GRS) seminar: “Tissue-like 3D environment shape modes of HIV-spread”

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18 Sep 2018
event

Groupe de Réflexion SIDA (GRS) seminar: “Defining Correlates of Immunology using Systems Serology”

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27 Aug 2018
news

MOOC on HIV Science (registration free)

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22 May 2018
event

Groupe de Réflexion SIDA (GRS) meeting: “Humanized mice models for HIV studies”

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27 Feb 2018
event

GRS (Groupe de Réflexion SIDA) meeting: “Immune reconstitution in HIV infection”

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02 Feb 2018
event

Groupe de Réflexion SIDA (GRS) meeting: “Metabolism and HIV”

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12 Jan 2018
publication

Immune Responses to Retroviruses

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01 Jan 2018
publication

Cellular Determinants of HIV Persistence on Antiretroviral Therapy

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31 Oct 2017
event

Groupe de Réflexion SIDA (GRS) meeting: “HIV vaccination strategies”

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11 Oct 2017
publication

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

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06 Sep 2017
publication

HLA-B*14:02-RESTRICTED ENV-SPECIFIC CD8+ T-CELL ACTIVITY HAS HIGHLY POTENT ANTIVIRAL EFFICACY ASSOCIATED WITH IMMUNE CONTROL OF HIV INFECTION

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28 Jun 2017
publication

Clinical and public health implications of acute and early HIV detection and treatment: a scoping review

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06 Apr 2017
event

GRS (Groupe de Reflexion SIDA) meeting: “Residual risk of HIV sexual transmission”

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03 Apr 2017
publication

A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level

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15 Mar 2017
publication

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents.

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24 Sep 2016
publication

Polyfunctional HIV-specific T cells in Post-Treatment Controllers

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26 Aug 2016
publication

Preservation of Lymphopoietic Potential and Virus Suppressive Capacity by CD8+ T Cells in HIV-2-Infected Controllers

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19 Aug 2016
publication

Strong Ifitm1 Expression In Cd4 T Cells In Hiv Controllers Is Correlated With Immune Activation

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01 Aug 2016
publication

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset.

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11 Jul 2016
publication

International AIDS Society global scientific strategy: towards an HIV cure 2016

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27 Apr 2016
publication

Long-term Spontaneous control of HIV-1 relates to low frequency of infected cells and inefficient viral reactivation

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12 Feb 2016
project

Group for AIDS Research

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01 Jan 2016
publication

Dendritic Cells from HIV Controllers Have Low Susceptibility to HIV-1 Infection In Vitro but High Capacity to Capture HIV-1 Particles.

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09 Dec 2015
publication

HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report

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10 Sep 2015
project

ICISTEM-International Collaboration to guide and investigate the potential for HIV cure by Stem Cell Transplantation

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09 Sep 2015
project

Etude ANRS-EP59-CLEAC (Comparison of Late versus Early Antiretroviral therapy in HIV-infected Children) : Etude physiopathologique comparant l’impact de l’instauration précoce (avant 6 mois) ou tardive (après 2 ans) du traitement antirétroviral sur l’évolution immuno-virologique des enfants infectés par le VIH-1 en période périnatale)

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03 Sep 2015
project

Natural Control of HIV-1 Infection

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03 Sep 2015
project

Role of CD8 T cells responses in the control of HIV-2 infection-ANRS Immunovir2

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16 Jul 2015
team

Viral reservoirs and immune control

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06 Jul 2015
publication

Immunologic and Virologic Progression in HIV Controllers: The Role of Viral “Blips” and Immune Activation in the ANRS CO21 CODEX Study

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21 Apr 2015
publication

Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

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18 Feb 2015
publication

Intensive five-drug antiretroviral therapy regimen versus standard triple-drug therapy during primary HIV-1 infection (OPTIPRIM-ANRS 147): a randomised, open-label, phase 3 trial

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14 Jan 2015
publication

Long-term control of simian immunodeficiency virus (SIV) in cynomolgus macaques not associated with efficient SIV-specific CD8+ T-cell responses

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12 Jan 2015
publication

Immediate T-Helper 17 Polarization Upon Triggering CD11b/c on HIV-Exposed Dendritic Cells

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01 Jan 2015
publication

Posttreatment controllers: what do they tell us?

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06 Aug 2014
publication

High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection

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07 Jul 2014
publication

Potential role for HIV-specific CD38-/HLA-DR+ CD8+ T cells in viral suppression and cytotoxicity in HIV controllers

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01 Apr 2014
publication

Reply to Pauls et al.: p21 is a master regulator of HIV replication in macrophages through dNTP synthesis block

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11 Mar 2014
publication

HIV cure research: advances and prospects.

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20 Feb 2014
publication

What is the significance of posttreatment control of HIV infection vis-à-vis functional cure?

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20 Feb 2014
publication

The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate

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20 Feb 2014
publication

Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients

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17 Jan 2014
publication

Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration

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01 Jan 2014
publication

Immune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?

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16 Oct 2013
publication

Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers

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30 Sep 2013
publication

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

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23 Sep 2013
publication

High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

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01 Jul 2013
publication

HIV controllers: a genetically determined or inducible phenotype?

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01 May 2013
publication

Will it be possible to live without antiretroviral therapy?

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29 Mar 2013
publication

CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection

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25 Mar 2013
publication

Immunovirologic control 24 months after interruption of antiretroviral therapy initiated close to HIV seroconversion

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14 Mar 2013
publication

Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

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01 Jan 2013
publication

NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers

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13 Oct 2012
publication

Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency

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11 Oct 2012
publication

Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes

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06 Mar 2012
publication

Kidney transplantation in an elite HIV controller: limited impact of immunosuppressive therapy on viro-immunological status

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03 Jun 2011
publication

Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers

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21 Apr 2011
publication

CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory

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01 Nov 2010
publication

Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals

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13 May 2010
publication

Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses

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15 Jun 2009
publication

Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses

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23 Apr 2009
publication

Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity

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04 Jan 2008
publication

The characteristic CD8+ T cell response in HIV controllers: an objective to achieve?

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03 Jan 2008
publication

Interfacial pre-transmembrane domains in viral proteins promoting membrane fusion and fission

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05 Nov 2007
publication

HIV controllers: how do they tame the virus?

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16 May 2007
publication

Ku80 participates in the targeting of retroviral transgenes to the chromatin of CHO cells

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11 May 2007
publication

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

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11 Apr 2007
publication

HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype

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08 Nov 2006
publication

Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks

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01 Nov 2006
publication

The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages

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01 Jun 2006
publication

Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells

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06 Apr 2005
publication

First Dominique Dormont International Conference on “Host-pathogen interactions in chronic infections – viral and host determinants of HCV, HCMV, and HIV infections”.

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01 Dec 2003
publication

Structural and functional roles of HIV-1 gp41 pretransmembrane sequence segmentation

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01 Nov 2003
publication

The hydrophobic internal region of bovine prion protein shares structural and functional properties with HIV type 1 fusion peptide

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01 Jan 2003
publication

Pre-transmembrane sequence of Ebola glycoprotein. Interfacial hydrophobicity distribution and interaction with membranes

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19 Aug 2002
publication

Conformational transitions of membrane-bound HIV-1 fusion peptide

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02 Apr 2002
publication

Sphingomyelin and cholesterol promote HIV-1 gp41 pretransmembrane sequence surface aggregation and membrane restructuring

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31 Aug 2000
publication

Sphingolipids (Galactosylceramide and Sulfatide) in Lamellar−Hexagonal Phospholipid Phase Transitions and in Membrane Fusion

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14 Jul 2000
publication

The pre-transmembrane region of the human immunodeficiency virus type-1 glycoprotein: a novel fusogenic sequence

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01 Jan 2000
publication

Equilibrium and Kinetic Studies of the Solubilization of Phospholipid−Cholesterol Bilayers by C12E8. The Influence of the Lipid Phase Structure

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