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© Charles Dauguet
Virus VIH-2, second virus du sida isolé en 1985 par l'équipe du Pr. Montagnier de l'Institut Pasteur.
Starting Date
01
Sep 2014
Ending Date
01
Sep 2017
Status
Ongoing
Members
3
Structures
2
Publications
1

About

The number of persons living with HIV-1 is around 35 million while roughly one million persons are living with HIV-2, with a decreasing prevalence. Both HIV-1 and HIV-2 are associated with AIDS, however most HIV-2 infected individuals can control the virus replication and maintain undetectable levels of viremia. The results generated by Dr. Saez-Cirion laboratory and others strongly suggest that “natural” HIV-1 controllers – a very rare phenotype- can contain virus replication through cytotoxic HIV-1 specific CD8 T cells in absence of antiretroviral treatment. However little is known on the role of CD8+ T cells to control HIV-2. In the context of the ANRS Immunovir2 study the team aims to understand the mechanisms of natural HIV-2 control and whether they may share similar characteristics to those found in HIV-1 controllers. The results of this study may help understanding the type of responses needed to control HIV disease progression and ultimately lead to the development of efficient immunotherapies to achieve remission.

Fundings