Laboratoire

Imagerie Dynamique du Neurone

Responsable

David Digregorio

CNRS UMR3571

Département de Neuroscience

• Biophysics
• Graphics and Image Processing
• Modeling
• Nanosciences
• Neurophysiology
• Neurosciences
• Optics
• Physics, Computer Science, Informatics Systems Biology and Technological Research
• Sensory systems
• Alzheimer
• Autism
• Neurological diseases
• Schizophrenia
• Model systems
• Mouse
• 2-photons microscopy
• Confocal Microscopy
• FRET/FLIM/FRAP/FCS
• In vivo molecular imaging
• Innovative microscopy approaches
• Microscopy
• Optical microscopy
• Optogenetics
• STED

VOIR TOUSFermer

Présentation

 

 

Membres

David Digregorio

Responsable de Structure

Responsable

Cécile Saint Cloment

Technicien(ne)

Nelson Rebola

Chercheur(euse) Permanent(e)

Andreas Hoehne

Etudiant(e) en thèse

Francisco José Urra Quiroz

Post-doctorant(e)

Maria Reva

Etudiant(e) en thèse

Alexandra Tran-Van-Minh

Post-doctorant(e)

Florian Ruckerl

Ingénieur(e) de Recherche

Kiri Couchman

Post-doctorant(e)

Gaël Moneron

Chercheur(euse) Permanent(e)

Alessandro Barri

Post-doctorant(e)

Grands Projets

Biologie quantitative

Le programme de biologie quantitative de l’Institut Pasteur est destiné à faciliter la recherche et l’éducation à l’interface entre la biologie et les sciences plus quantitatives. L’un des principaux objectifs de la biologie quantitative […]

Projets

Dynamic Neuronal Imaging

Understanding how information is processed within neuronal networks requires knowledge of how neurons use cellular and molecular mechanisms to transform information communicated by synapses. Defects in the communication between synapses are thought to be […]

Emplois

Etudiant(e) M2

Master 2 project: Model based inference of neural activity from nonlinear calcium signals

Background: Understanding information processing in the brain requires recording their electrical and biochemical activity across broad spatial (nm to mm) and with fast temporal resolution (~1ms). This is currently achieved through direct electrical recordings […]

Etudiant(e) M2

Master 2 project: Development of an ultrafast 3D beam-scanner for smart microscopy

Background: Information processing in the brain is based on electrical and chemical signals that propagate within neurons as well as between networks of neurons across millimeters and centimeters of tissue but on the millisecond […]

Etudiant(e) M2

Master 2 project: Development of a novel microscopy modality for imaging deep in scattering media

Background: Studying brain function requires the understanding of how neurons communicate with each other at specialized sub-micron sized contacts called synapses – the fundamental unit of computation within the brain. However these structures exhibit […]

Etudiant(e) M2

Master 2 project: Cellular and circuit mechanisms of information processing in cerebellar and cortical microcircuits

Background: The efficiency, precision and plasticity of communication at synapses is diverse throughout the brain, yet fundamental to establishing, directing and adapting specific information routes and processes that underlie behavior. Projects in the laboratory […]

Financements

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Publications

• 2016
  Differential Dendritic Integration of Synaptic Potentials and Calcium in Cerebellar Interneurons - Tran-Van-Minh A, Abrahamsson T, Cathala L, DiGregorio DA - Neuron
• 2016
  A Role for Synaptic Input Distribution in a Dendritic Computation of Motion Direction in the Retina - Vlasits AL, Morrie RD, Tran-Van-Minh A, Bleckert A, Gainer CF, DiGregorio DA, Feller MB - Neuron
• 2015
  Optical control of NMDA receptors with a diffusible photoswitch - Laprell L, Repak E, Franckevicius V, Hartrampf F, Terhag J, Hollmann M, Sumser M, Rebola N, DiGregorio DA, Trauner D - Nature communications
• 2015
  Synaptic diversity enables temporal coding of coincident multisensory inputs in single neurons - Chabrol FP, Arenz A, Wiechert MT, Margrie TW, DiGregorio DA - Nature neuroscience
• 2015
  Contribution of sublinear and supralinear dendritic integration to neuronal computations - Tran-Van-Minh A, Cazé RD, Abrahamsson T, Cathala L, Gutkin BS, DiGregorio DA - Frontiers in cellular neuroscience
• 2015
  Ca2+ channel to synaptic vesicle distance accounts for the readily releasable pool kinetics at a functionally mature auditory synapse - Chen Z, Das B, Nakamura Y, DiGregorio DA, Young SM - The Journal of neuroscience : the official journal of the Society for Neuroscience
• 2014
  Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development - Nakamura Y, Harada H, Kamasawa N, Matsui K, Rothman JS, Shigemoto R, Silver RA, DiGregorio DA, Takahashi T - Neuron
• 2014
  Non-associative potentiation of perisomatic inhibition alters the temporal coding of neocortical layer 5 pyramidal neurons - Lourenço J, Pacioni S, Rebola N, van Woerden GM, Marinelli S, DiGregorio D, Bacci A - PLoS biology
• 2014
  Confocal spot detection of presynaptic Ca²⁺ domains - DiGregorio D - Cold Spring Harbor protocols
• 2012
  Two-photon compatibility and single-voxel, single-trial detection of subthreshold neuronal activity by a two-component optical voltage sensor - Fink AE, Bender KJ, Trussell LO, Otis TS, DiGregorio DA - PloS one
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  Voir la liste complète de publications

Former members

François Chabrol
Emilienne Repak
Yukihiro Nakamura
Thérèse Abrahamsson
Ann Fink
Jonathan Bradley

Marla Feller (Berkeley, sabbatical)
Graeme Davis (UCSF, sabbatical)
Thomas Otis (UCLA, sabbatical)

Group Picture

Unit of Dynamic Neuronal Imaging, Institut Pasteur, September 2015

Contact

David DiGregorio

email: david.digregorio@pasteur.fr