Timeline

Pierre Lafaye
Head of Facility
01 Jul 2021
publication

A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.

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30 Sep 2020
publication

Brain Delivery of Single-Domain Antibodies: A Focus on VHH and VNAR.

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10 Apr 2020
project

CORONABODIES

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16 Jan 2020
project

VenoMATIcs: Toward a Global Management of Venoms and Envenomations: the Pasteur network Translational Approach

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01 Dec 2019
publication

[New formats for improving brain drug delivery of antibodies: the blood-brain barrier case].

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21 Jun 2019
project

Rapid diagnostic test of diphtheria

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07 Nov 2018
project

High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)

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25 Oct 2018
publication

Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.

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27 Feb 2018
project

Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)

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11 Jul 2017
publication

Paper microfluidics for nucleic acid amplification testing (NAAT) of infectious diseases.

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06 Jul 2017
publication

Selection of similar single domain antibodies from two immune VHH libraries obtained from two alpacas by using different selection methods

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28 Jun 2017
publication

Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer’s disease

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02 May 2017
publication

Paper-based RNA detection and multiplexed analysis for Ebola virus diagnostics

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10 Dec 2016
publication

Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.

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25 Nov 2015
publication

Ebola: lessons learned and future challenges for Europe

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04 Nov 2015
project

Protein conjugates for the diagnosis of Alzheimer’s disease

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01 Nov 2015
publication

Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes

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30 Sep 2015
publication

New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates

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12 Sep 2015
project

ChagasDiag

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19 Mar 2015
project

Antibody based dipsticks tests

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19 Mar 2015
project

Use of nanobodies for imaging plaques and tangles in Alzheimer’s disease

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17 Feb 2015
team

Antibody Engineering

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28 Jun 2014
publication

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

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30 Jul 2013
publication

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

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27 Jun 2013
publication

Sensitivity and Specificity of a New Vertical Flow Rapid Diagnostic Test for the Serodiagnosis of Human Leptospirosis

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12 Jun 2013
publication

Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.

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16 May 2013
publication

Laboratory evaluation of a rapid diagnostic test for Neisseria meningitidis serogroup A.

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02 Jul 2012
publication

Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein

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22 Jun 2012
publication

Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging

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21 Apr 2012
publication

Influence of preliminary etching on the stability of bonds created by one-step self-etch bonding systems

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31 Oct 2011
publication

Molecular characterization of a Streptococcus gallolyticus genomic island encoding a pilus involved in endocarditis

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14 Jul 2009
publication

Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies

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28 Apr 2009
publication

Development and evaluation of two simple, rapid immunochromatographic tests for the detection of Yersinia pestis antibodies in humans and reservoirs

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12 Nov 2008
publication

Field evaluation of rapid diagnostic tests for meningococcal meningitis in Niger

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18 Oct 2008
publication

Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation

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22 Sep 2008
publication

An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype

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01 Aug 2008
publication

Tetrameric and homodimeric camelid IgGs originate from the same IgH locus

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01 Jan 2008
publication

Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1

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07 May 2007
publication

Biological diagnosis of meningococcal meningitis in the African meningitis belt: current epidemic strategy and new perspectives

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18 Apr 2007
publication

Dipstick for rapid diagnosis of Shigella flexneri 2a in stool

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01 Sep 2006
publication

New rapid diagnostic tests for Neisseria meningitidis serogroups A, W135, C, and Y

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01 Aug 2006
publication

Cloning and expression of functional single-chain Fv antibodies directed against NIa and coat proteins of potato virus Y

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01 Feb 2006
publication

Field evaluation of a rapid immunochromatographic dipstick test for the diagnosis of cholera in a high-risk population

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01 Feb 2006
publication

Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine

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01 Jan 2006
publication

Evaluation of three rapid diagnostic tests for cholera: does the skill level of the technician matter?

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01 Jun 2005
publication

[Rapid diagnosis of outbreak-prone bacterial diseases]

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08 Dec 2004
publication

Immunohistochemical detection of the human cytochrome P4507B1: production of a monoclonal antibody after cDNA immunization

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01 Nov 2004
publication

Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies

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29 Jul 2004
publication

Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

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01 Aug 2003
publication

Use of dipsticks for rapid diagnosis of cholera caused by Vibrio cholerae O1 and O139 from rectal swabs

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16 May 2003
publication

Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidate

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01 May 2003
publication

One-step immunochromatographic dipstick tests for rapid detection of Vibrio cholerae O1 and O139 in stool samples

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01 May 2003
publication

Expression of anti human IL-4 and IL-6 scFvs in transgenic tobacco plants

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18 Jan 2003
publication

Development and testing of a rapid diagnostic test for bubonic and pneumonic plague

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01 Jan 2003
publication

Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain

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01 Jan 2003
publication

[Interest in rapid immunochromatography tests for surveillance of characteristic diseases epidemic in developing countries: the example of plague in Madagascar]

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29 Nov 2002
publication

The binding of synthetic analogs of the upstream, terminal residue of the O-polysaccharides (O-PS) of Vibrio cholerae O:1 serotypes Ogawa and Inaba to two murine monoclonal antibodies (MAbs) specific for the Ogawa lipopolysaccharide (LPS)

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01 Aug 2001
publication

Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism

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15 May 2001
publication

Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies

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01 May 2001
publication

Preparation, immunogenicity, and protective efficacy, in a murine model, of a conjugate vaccine composed of the polysaccharide moiety of the lipopolysaccharide of Vibrio cholerae O139 bound to tetanus toxoid

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01 Apr 2000
publication

Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library

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01 Jan 2000
publication

7 alpha-hydroxy-dehydroepiandrosterone and immune response

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18 Oct 1999
publication

The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens

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01 Oct 1999
publication

The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling

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01 Aug 1999
publication

Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR

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01 May 1999
publication

Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin

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15 Apr 1999
publication

A recombinant Fab neutralizes dengue virus in vitro

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01 Jul 1998
publication

A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes its toxicity

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12 May 1998
publication

Polyreactive anti-DNA monoclonal antibodies and a derived peptide as vectors for the intracytoplasmic and intranuclear translocation of macromolecules

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30 Jan 1998
publication

On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba

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01 Jan 1998
publication

Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate

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01 Nov 1997
publication

Characterization of C-terminal merozoite surface protein-1 baculovirus recombinant proteins from Plasmodium vivax and Plasmodium cynomolgi as recognized by the natural anti-parasite immune response

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01 Sep 1997
publication

Phage-displayed and soluble mouse scFv fragments neutralize rabies virus

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01 Jul 1997
publication

B lineage-restricted rearrangement of a human Ig kappa transgene

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01 Jun 1997
publication

Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library

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01 May 1997
publication

Mimotopes of polyreactive anti-DNA antibodies identified using phage-display peptide libraries

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01 Aug 1996
publication

Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library

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01 Aug 1996
publication

Internalin must be on the bacterial surface to mediate entry of Listeria monocytogenes into epithelial cells

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01 Feb 1996
publication

Lack of cleavage of IcsA in Shigella flexneri causes aberrant movement and allows demonstration of a cross-reactive eukaryotic protein

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01 Jan 1996
publication

Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab

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01 Jul 1995
publication

Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab

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01 Apr 1995
publication

Cloning and expression of mamba toxins

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28 Feb 1994
publication

Development of a bispecific monoclonal antibody for use in molecular hybridisation

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01 Sep 1993
publication

Characterization of B-cell epitopes on IpaB, an invasion-associated antigen of Shigella flexneri: identification of an immunodominant domain recognized during natural infection

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01 Aug 1993
publication

Comparison of various methods and reagents for species identification of Staphylococcus aureus positive or negative for the mecA gene

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01 Jun 1993
publication

Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker

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01 May 1993
publication

New latex reagent using monoclonal antibodies to capsular polysaccharide for reliable identification of both oxacillin-susceptible and oxacillin-resistant Staphylococcus aureus

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01 Jan 1993
publication

Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis

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01 Dec 1992
publication

Detection of Pneumocystis carinii in bronchoalveolar lavage fluid by dot immunobinding assay and immunofluorescence

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01 Jun 1992
publication

Production and characterization of monoclonal antibodies to human Pneumocystis carinii for the diagnosis of P. carinii pneumonia

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01 May 1992
publication

Identification and characterization of B-cell epitopes of IpaC, an invasion-associated protein of Shigella flexneri

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01 Dec 1991
publication

Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O

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01 Oct 1991
publication

Immunological screening of a glycoprotein antigen expressed by Zajdela ascites hepatoma cells on normal rat tissues and tumour cells

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01 Jul 1991
publication

Production of polyclonal and monoclonal antibodies against group A, B, and C capsular polysaccharides of Neisseria meningitidis and preparation of latex reagents

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01 Feb 1990
publication

Potential proteolytic activity of fibronectin: fibronectin laminase and its substrate specificity

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01 May 1989
publication

Direct testing of blood culture for detection of the serotype 5 and 8 capsular polysaccharides of Staphylococcus aureus

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18 Jul 1988
publication

Identification of two fixation sites for penicilloyl groups on the albumin molecule from penicillin-treated patients

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01 Jul 1988
publication

Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients

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10 Aug 1987
publication

Location of penicilloyl groups on CNBr fragments of the albumin from penicillin-treated patients

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01 May 1985
publication

Enzyme-linked immunosorbent assay for measurement of penicilloyl groups

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01 Jan 1985
publication

Study of the antigenic structure of human serum albumin with monoclonal antibodies

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