Timeline

Pierre Lafaye
Head of Facility
04 Nov 2024
21 Jun 2024
publication
Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus.
Read more18 Mar 2024
publication
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Read more01 Jan 2024
03 Nov 2023
25 Oct 2023
25 Sep 2023
publication
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Read more18 Jul 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Read more22 Jun 2023
25 May 2023
publication
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Read more09 Mar 2023
publication
Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases.
Read more25 Oct 2022
project
Advances in cancer immunotherapy development: VHH-based immune checkpoint inhibitors targeting the receptor ILT4
Read more01 Jan 2022
publication
Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein.
Read more01 Jul 2021
publication
A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.
Read more30 Sep 2020
10 Apr 2020
16 Jan 2020
project
VenoMATIcs: Toward a Global Management of Venoms and Envenomations: the Pasteur network Translational Approach
Read more01 Dec 2019
publication
[New formats for improving brain drug delivery of antibodies: the blood-brain barrier case].
Read more09 Apr 2019
publication
A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain.
Read more01 Dec 2018
publication
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.
Read more07 Nov 2018
project
High throughput selection of VHHs by droplet based microfluidics (PTR nanofluidic)
Read more25 Oct 2018
publication
[Single-chain antibodies from alpaca for the detection of Fasciola hepatica antigens].
Read more01 Oct 2018
publication
Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases.
Read more27 Feb 2018
project
Toxins and VHHs as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Read more01 Aug 2017
publication
Selection of similar single domain antibodies from two immune VHH libraries obtained from two alpacas by using different selection methods.
Read more11 Jul 2017
publication
Paper microfluidics for nucleic acid amplification testing (NAAT) of infectious diseases.
Read more02 May 2017
publication
Paper-based RNA detection and multiplexed analysis for Ebola virus diagnostics.
Read more01 Jan 2017
publication
Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer’s disease.
Read more10 Dec 2016
publication
Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.
Read more25 Nov 2015
05 Nov 2015
publication
Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Read more04 Nov 2015
30 Sep 2015
publication
New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates
Read more12 Sep 2015
19 Mar 2015
17 Feb 2015
28 Jun 2014
publication
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
Read more30 Jul 2013
publication
An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission
Read more01 Jul 2013
publication
Laboratory evaluation of a rapid diagnostic test for Neisseria meningitidis serogroup A.
Read more12 Jun 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Read more02 Jul 2012
publication
Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein.
Read more22 Jun 2012
publication
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging
Read more31 Oct 2011
publication
Molecular characterization of a Streptococcus gallolyticus genomic island encoding a pilus involved in endocarditis
Read more14 Jul 2009
publication
Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies
Read more18 Oct 2008
publication
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation
Read more22 Sep 2008
publication
An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype
Read more01 Aug 2008
01 Jan 2008
publication
Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
Read more18 Apr 2007
01 Aug 2006
publication
Cloning and expression of functional single-chain Fv antibodies directed against NIa and coat proteins of potato virus Y
Read more01 Feb 2006
publication
Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
Read more08 Dec 2004
publication
Immunohistochemical detection of the human cytochrome P4507B1: production of a monoclonal antibody after cDNA immunization
Read more01 Nov 2004
publication
Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies
Read more29 Jul 2004
publication
Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.
Read more16 May 2003
publication
Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidate
Read more01 May 2003
18 Jan 2003
publication
Development and testing of a rapid diagnostic test for bubonic and pneumonic plague
Read more01 Jan 2003
publication
Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain
Read more01 Aug 2001
publication
Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism
Read more15 May 2001
publication
Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies
Read more01 Apr 2000
publication
Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library
Read more01 Jan 2000
18 Oct 1999
publication
The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens
Read more01 Oct 1999
publication
The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling
Read more01 Aug 1999
publication
Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR
Read more01 May 1999
publication
Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin
Read more15 Apr 1999
01 Jul 1998
publication
A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes its toxicity
Read more30 Jan 1998
publication
On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba
Read more01 Jan 1998
publication
Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate
Read more01 Sep 1997
01 Jun 1997
publication
Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library
Read more01 Aug 1996
publication
Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library
Read more01 Aug 1996
publication
Internalin must be on the bacterial surface to mediate entry of Listeria monocytogenes into epithelial cells
Read more01 Jan 1996
publication
Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab
Read more01 Jul 1995
publication
Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab
Read more01 Apr 1995
01 Jun 1993
publication
Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker
Read more01 Jan 1993
publication
Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis
Read more01 Dec 1991
publication
Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O
Read more01 Feb 1990
publication
Potential proteolytic activity of fibronectin: fibronectin laminase and its substrate specificity
Read more18 Jul 1988
publication
Identification of two fixation sites for penicilloyl groups on the albumin molecule from penicillin-treated patients
Read more01 Jul 1988
publication
Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients
Read more10 Aug 1987
publication
Location of penicilloyl groups on CNBr fragments of the albumin from penicillin-treated patients
Read more01 May 1985
01 Jan 1985
publication