Ligne de temps
Pierre Lafaye
Responsable de Plateforme
18 mars 2024
publication
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Lire plus03 nov. 2023
25 oct. 2023
25 sept. 2023
publication
An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies.
Lire plus18 juil. 2023
publication
T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations
Lire plus22 juin 2023
25 mai 2023
publication
Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor.
Lire plus09 mars 2023
publication
Development of Nanobodies as Theranostic Agents against CMY-2-Like Class C β-Lactamases.
Lire plus25 oct. 2022
project
Advances in cancer immunotherapy development: VHH-based immune checkpoint inhibitors targeting the receptor ILT4
Lire plus01 janv. 2022
publication
Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein.
Lire plus01 juil. 2021
publication
A Novel Nanobody Precisely Visualizes Phosphorylated Histone H2AX in Living Cancer Cells under Drug-Induced Replication Stress.
Lire plus30 sept. 2020
10 avr. 2020
16 janv. 2020
project
VenoMATIcs: Toward a Global Management of Venoms and Envenomations: the Pasteur network Translational Approach
Lire plus01 déc. 2019
publication
[New formats for improving brain drug delivery of antibodies: the blood-brain barrier case].
Lire plus09 avr. 2019
publication
A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain.
Lire plus01 déc. 2018
publication
Adhesion to nanofibers drives cell membrane remodeling through one-dimensional wetting.
Lire plus07 nov. 2018
project
High throughput selection of nanobodies by droplet based microfluidics (PTR nanofluidic)
Lire plus25 oct. 2018
publication
[Single-chain antibodies from alpaca for the detection of Fasciola hepatica antigens].
Lire plus01 oct. 2018
publication
Use of camel single-domain antibodies for the diagnosis and treatment of zoonotic diseases.
Lire plus27 févr. 2018
project
Toxins and nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors (PTR Nicobinder)
Lire plus01 août 2017
publication
Selection of similar single domain antibodies from two immune VHH libraries obtained from two alpacas by using different selection methods.
Lire plus11 juil. 2017
publication
Paper microfluidics for nucleic acid amplification testing (NAAT) of infectious diseases.
Lire plus02 mai 2017
publication
Paper-based RNA detection and multiplexed analysis for Ebola virus diagnostics.
Lire plus01 janv. 2017
publication
Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer’s disease.
Lire plus10 déc. 2016
publication
Camelid single-domain antibodies: A versatile tool for in vivo imaging of extracellular and intracellular brain targets.
Lire plus25 nov. 2015
05 nov. 2015
publication
Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes.
Lire plus04 nov. 2015
30 sept. 2015
publication
New tools for amyloid plaques detection by MRI: Gadolinium-VHH antibody conjugates
Lire plus12 sept. 2015
19 mars 2015
17 févr. 2015
28 juin 2014
publication
Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity
Lire plus30 juil. 2013
publication
An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission
Lire plus12 juin 2013
publication
Penicillin resistance compromises Nod1-dependent proinflammatory activity and virulence fitness of neisseria meningitidis.
Lire plus16 mai 2013
publication
Laboratory evaluation of a rapid diagnostic test for Neisseria meningitidis serogroup A.
Lire plus02 juil. 2012
publication
Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein.
Lire plus22 juin 2012
publication
Cell-penetrating anti-GFAP VHH and corresponding fluorescent fusion protein VHH-GFP spontaneously cross the blood-brain barrier and specifically recognize astrocytes: application to brain imaging
Lire plus31 oct. 2011
publication
Molecular characterization of a Streptococcus gallolyticus genomic island encoding a pilus involved in endocarditis
Lire plus14 juil. 2009
publication
Llama VHH antibody fragments against GFAP: better diffusion in fixed tissues than classical monoclonal antibodies
Lire plus18 oct. 2008
publication
Single-domain antibodies recognize selectively small oligomeric forms of amyloid beta, prevent Abeta-induced neurotoxicity and inhibit fibril formation
Lire plus22 sept. 2008
publication
An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype
Lire plus01 août 2008
01 janv. 2008
publication
Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1
Lire plus18 avr. 2007
01 août 2006
publication
Cloning and expression of functional single-chain Fv antibodies directed against NIa and coat proteins of potato virus Y
Lire plus01 févr. 2006
publication
Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
Lire plus08 déc. 2004
publication
Immunohistochemical detection of the human cytochrome P4507B1: production of a monoclonal antibody after cDNA immunization
Lire plus01 nov. 2004
publication
Functional analysis of Bacillus anthracis protective antigen by using neutralizing monoclonal antibodies
Lire plus29 juil. 2004
publication
Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.
Lire plus16 mai 2003
publication
Crystal structure of a Fab complex formed with PfMSP1-19, the C-terminal fragment of merozoite surface protein 1 from Plasmodium falciparum: a malaria vaccine candidate
Lire plus01 mai 2003
18 janv. 2003
publication
Development and testing of a rapid diagnostic test for bubonic and pneumonic plague
Lire plus01 janv. 2003
publication
Tetanus neurotoxin-insensitive vesicle-associated membrane protein localizes to a presynaptic membrane compartment in selected terminal subsets of the rat brain
Lire plus01 août 2001
publication
Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism
Lire plus15 mai 2001
publication
Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies
Lire plus01 avr. 2000
publication
Neutralizing human anti crotoxin scFv isolated from a nonimmunized phage library
Lire plus01 janv. 2000
18 oct. 1999
publication
The 7alpha-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigens
Lire plus01 oct. 1999
publication
The 213-amino-acid leucine-rich repeat region of the listeria monocytogenes InlB protein is sufficient for entry into mammalian cells, stimulation of PI 3-kinase and membrane ruffling
Lire plus01 août 1999
publication
Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR
Lire plus01 mai 1999
publication
Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin
Lire plus15 avr. 1999
01 juil. 1998
publication
A monoclonal antibody directed against the non-toxic subunit of a dimeric phospholipase A2 neurotoxin, crotoxin, neutralizes its toxicity
Lire plus30 janv. 1998
publication
On the antigenic determinants of the lipopolysaccharides of Vibrio cholerae O:1, serotypes Ogawa and Inaba
Lire plus01 janv. 1998
publication
Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate
Lire plus01 sept. 1997
01 juin 1997
publication
Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library
Lire plus01 août 1996
publication
Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library
Lire plus01 août 1996
publication
Internalin must be on the bacterial surface to mediate entry of Listeria monocytogenes into epithelial cells
Lire plus01 janv. 1996
publication
Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab
Lire plus01 juil. 1995
publication
Similar binding properties for a neutralizing anti-tetanus toxoid human monoclonal antibody and its bacterially expressed Fab
Lire plus01 avr. 1995
01 juin 1993
publication
Cloning and functional expression of dendrotoxin K from black mamba, a K+ channel blocker
Lire plus01 janv. 1993
publication
Monoclonal antibodies for identification of Borrelia afzelii sp. nov. associated with late cutaneous manifestations of Lyme borreliosis
Lire plus01 déc. 1991
publication
Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O
Lire plus01 févr. 1990
publication
Potential proteolytic activity of fibronectin: fibronectin laminase and its substrate specificity
Lire plus18 juil. 1988
publication
Identification of two fixation sites for penicilloyl groups on the albumin molecule from penicillin-treated patients
Lire plus01 juil. 1988
publication
Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients
Lire plus10 août 1987
publication
Location of penicilloyl groups on CNBr fragments of the albumin from penicillin-treated patients
Lire plus01 mai 1985
01 janv. 1985
publication