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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : Lancet (London, England)

Development and testing of a rapid diagnostic test for bubonic and pneumonic plague

Team: Antibody Engineering
Team: Yersinia
Member: Pierre Lafaye
Member: Elisabeth Carniel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Lancet (London, England) - 18 Jan 2003

Chanteau S, Rahalison L, Ralafiarisoa L, Foulon J, Ratsitorahina M, Ratsifasoamanana L, Carniel E, Nato F

Link to Pubmed [PMID] – 12547544

Lancet 2003 Jan;361(9353):211-6

Plague is often fatal without prompt and appropriate treatment. It affects mainly poor and remote populations. Late diagnosis is one of the major causes of human death and spread of the disease, since it limits the effectiveness of control measures. We aimed to develop and assess a rapid diagnostic test (RDT) for plague.