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© Pierre Lafaye
Astrocytes marqués par des anticorps VHH anti-GFAP. Des anticorps d'alpagas dirigés contre une protéine spécifique des astrocytes, la GFAP (Glial Fibrillary Acidic Protein), ont été obtenus à partir de camélidés immunisés. La partie VHH (partie de l'anticorps qui reconnaît l'antigène) a été exprimée sous forme recombinante chez Escherichia coli.
Publication : Molecular microbiology

Interactions of HasA, a bacterial haemophore, with haemoglobin and with its outer membrane receptor HasR

Team: Antibody Engineering
Member: Pierre Lafaye
Member: Michel Goldberg
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 01 Aug 1999

Létoffé S, Nato F, Goldberg ME, Wandersman C

Link to Pubmed [PMID] – 10417645

Mol. Microbiol. 1999 Aug;33(3):546-55

The major mechanism by which bacteria acquire free or haemoglobin-bound haem involves direct binding of haem to specific outer membrane receptors. Serratia marcescens and Pseudomonas aeruginosa have an alternative system, which involves an extracellular haemophore, HasA, that captures free or haemoglobin-bound haem and shuttles it to a specific cell surface outer membrane receptor, HasR. Both haem-free (apoprotein) and haem-loaded (holoprotein) HasA bind to HasR, evidence for direct protein-protein interactions between HasA and HasR. HasA binding to HasR takes place in a tonB mutant. TonB is thus required for a step subsequent to HasA binding.