Timeline

Claude Parsot
Permanent Researcher
26 May 2015
publication

Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA

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11 May 2015
team

Enteric Bacterial Pathogens

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26 Mar 2015
publication

Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp

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26 May 2014
publication

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection

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22 May 2014
publication

Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG

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12 Feb 2014
publication

A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread

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12 Mar 2012
publication

Characterization of the promoter, MxiE box and 5′ UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri

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27 May 2010
publication

The 33 carboxyl-terminal residues of Spa40 orchestrate the multi-step assembly process of the type III secretion needle complex in Shigella flexneri

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20 Jan 2009
publication

Shigella type III secretion effectors: how, where, when, for what purposes?

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10 Nov 2008
publication

MxiC is secreted by and controls the substrate specificity of the Shigella flexneri type III secretion apparatus

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09 Nov 2008
publication

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

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21 Mar 2008
publication

Cell regulation

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08 Dec 2007
publication

IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri

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15 Mar 2007
publication

Type III secretion effectors of the IpaH family are E3 ubiquitin ligases

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10 Dec 2006
publication

An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses

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24 Oct 2006
publication

Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri

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18 Oct 2006
publication

IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus

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07 Jul 2006
publication

Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri

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01 Feb 2006
publication

Transcriptional slippage in mxiE controls transcription and translation of the downstream mxiD gene, which encodes a component of the Shigella flexneri type III secretion apparatus

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01 Jan 2006
publication

[Control of the host inflammatory response during Shigella flexneri infection]

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15 Sep 2005
publication

Shigella spp. and enteroinvasive Escherichia coli pathogenicity factors

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14 Sep 2005
publication

The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes

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01 Jun 2005
publication

A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri

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01 Apr 2005
publication

Frameshifting by transcriptional slippage is involved in production of MxiE, the transcription activator regulated by the activity of the type III secretion apparatus in Shigella flexneri

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01 Mar 2005
publication

Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri

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25 Feb 2005
publication

Optimization of virulence functions through glucosylation of Shigella LPS

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16 Apr 2004
publication

Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity

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01 Aug 2003
publication

The evolutionary history of Shigella and enteroinvasive Escherichia coli revised

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01 Aug 2003
publication

MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneri

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01 Feb 2003
publication

The various and varying roles of specific chaperones in type III secretion systems

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01 Jan 2003
publication

Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system

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01 Dec 2002
publication

Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri

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01 Oct 2002
publication

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology

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01 Oct 2002
publication

Chaperones of the type III secretion pathway: jacks of all trades

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15 May 2002
publication

Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium

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01 Mar 2002
publication

Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus

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01 Mar 2002
publication

Spa15 of Shigella flexneri, a third type of chaperone in the type III secretion pathway

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01 Nov 2001
publication

Characterization of the interaction partners of secreted proteins and chaperones of Shigella flexneri

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01 Feb 2001
publication

Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery

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01 Feb 2001
publication

Structure and composition of the Shigella flexneri “needle complex”, a part of its type III secreton

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01 Nov 2000
publication

The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri

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01 Oct 2000
publication

IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation

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01 Sep 2000
publication

Characterization of the interaction of IpaB and IpaD, proteins required for entry of Shigella flexneri into epithelial cells, with a lipid membrane

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01 Mar 2000
publication

The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread

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01 Nov 1999
publication

The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes

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01 Sep 1999
publication

The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri

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01 Jul 1998
publication

SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity

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15 May 1998
publication

Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins

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01 Oct 1997
publication

Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation

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01 May 1997
publication

Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis

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01 Mar 1997
publication

SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri

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01 Jan 1997
publication

Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes

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01 Jan 1996
publication

Invasion and the pathogenesis of Shigella infections

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01 Aug 1995
publication

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

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01 Aug 1995
publication

MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination

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01 Jul 1995
publication

SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion

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01 Apr 1995
publication

Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures

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01 Dec 1994
publication

Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent

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15 Nov 1994
publication

The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD

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01 Nov 1994
publication

Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri

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01 Jan 1994
publication

Shigella flexneri: genetics of entry and intercellular dissemination in epithelial cells

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01 Sep 1993
publication

Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells

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01 Aug 1993
publication

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement

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01 May 1993
publication

Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus

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01 Apr 1993
publication

Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement

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01 Jan 1993
publication

MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri lpa invasins

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01 Dec 1992
publication

MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins

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01 Aug 1992
publication

Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression

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01 Jun 1992
publication

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

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01 Jan 1992
publication

Identification of a lacZ gene in Vibrio cholerae

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15 Jun 1991
publication

Regulatory cascade controls virulence in Vibrio cholerae

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01 May 1991
publication

Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator

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01 Mar 1991
publication

ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae

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01 Dec 1990
publication

Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response

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15 Oct 1988
publication

Cloning and nucleotide sequence of the Bacillus subtilis hom gene coding for homoserine dehydrogenase. Structural and evolutionary relationships with Escherichia coli aspartokinases-homoserine dehydrogenases I and II

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01 Sep 1988
publication

Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes

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01 Sep 1988
publication

Pseudomonas aeruginosa diaminopimelate decarboxylase: evolutionary relationship with other amino acid decarboxylases

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01 Jan 1988
publication

Methionine biosynthesis in Enterobacteriaceae: biochemical, regulatory, and evolutionary aspects

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01 Sep 1987
publication

Enzyme specialization during the evolution of amino acid biosynthetic pathways

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01 Aug 1987
publication

A common origin for enzymes involved in the terminal step of the threonine and tryptophan biosynthetic pathways

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01 Jul 1987
publication

Cloning and nucleotide sequence of the thrB gene from the cyanobacterium Calothrix PCC 7601

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25 Jun 1987
publication

Nucleotide sequence of the overlapping genes for the subunits of Bacillus subtilis aspartokinase II and their control regions

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01 Nov 1986
publication

Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase

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01 Feb 1986
publication

Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region

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25 Jan 1986
publication

Nucleotide sequence of lysC gene encoding the lysine-sensitive aspartokinase III of Escherichia coli K12. Evolutionary pathway leading to three isofunctional enzymes

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22 Jul 1985
publication

Two functional domains conserved in major and alternate bacterial sigma factors

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11 Nov 1983
publication

Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12

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25 Jun 1983
publication

In vitro transcription of the cloned chromosomal crystal gene from Bacillus thuringiensis

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01 Jan 1982
publication

DNA sequence change of a deletion mutation abolishing attenuation control of the threonine operon of E. coli K12

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