Timeline
Claude Parsot
Permanent Researcher
26 May 2015
publication
Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA
Read more26 Mar 2015
publication
Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp
Read more02 Jun 2014
22 May 2014
publication
Structural basis for the inhibition of host protein ubiquitination by Shigella effector kinase OspG
Read more12 Feb 2014
publication
A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread
Read more12 Mar 2012
publication
Characterization of the promoter, MxiE box and 5′ UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri
Read more27 May 2010
publication
The 33 carboxyl-terminal residues of Spa40 orchestrate the multi-step assembly process of the type III secretion needle complex in Shigella flexneri
Read more20 Jan 2009
10 Nov 2008
publication
MxiC is secreted by and controls the substrate specificity of the Shigella flexneri type III secretion apparatus
Read more09 Nov 2008
publication
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases
Read more21 Mar 2008
08 Dec 2007
publication
IpgB1 and IpgB2, two homologous effectors secreted via the Mxi-Spa type III secretion apparatus, cooperate to mediate polarized cell invasion and inflammatory potential of Shigella flexenri
Read more15 Mar 2007
10 Dec 2006
publication
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses
Read more24 Oct 2006
publication
Transcriptional slippage controls production of type III secretion apparatus components in Shigella flexneri
Read more18 Oct 2006
publication
IpaD is localized at the tip of the Shigella flexneri type III secretion apparatus
Read more07 Jul 2006
publication
Structural mimicry for vinculin activation by IpaA, a virulence factor of Shigella flexneri
Read more01 Feb 2006
publication
Transcriptional slippage in mxiE controls transcription and translation of the downstream mxiD gene, which encodes a component of the Shigella flexneri type III secretion apparatus
Read more01 Jan 2006
publication
[Control of the host inflammatory response during Shigella flexneri infection]
Read more15 Sep 2005
14 Sep 2005
publication
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
Read more01 Jun 2005
publication
A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri
Read more01 Apr 2005
publication
Frameshifting by transcriptional slippage is involved in production of MxiE, the transcription activator regulated by the activity of the type III secretion apparatus in Shigella flexneri
Read more01 Mar 2005
publication
Analysis of virulence plasmid gene expression defines three classes of effectors in the type III secretion system of Shigella flexneri
Read more25 Feb 2005
16 Apr 2004
publication
Structure of Spa15, a type III secretion chaperone from Shigella flexneri with broad specificity
Read more01 Aug 2003
publication
The evolutionary history of Shigella and enteroinvasive Escherichia coli revised
Read more01 Aug 2003
publication
MxiK and MxiN interact with the Spa47 ATPase and are required for transit of the needle components MxiH and MxiI, but not of Ipa proteins, through the type III secretion apparatus of Shigella flexneri
Read more01 Feb 2003
publication
The various and varying roles of specific chaperones in type III secretion systems
Read more01 Jan 2003
publication
Identification of substrates and chaperone from the Yersinia enterocolitica 1B Ysa type III secretion system
Read more01 Dec 2002
publication
Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri
Read more01 Oct 2002
publication
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology
Read more01 Oct 2002
15 May 2002
publication
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium
Read more01 Mar 2002
publication
Regulation of transcription by the activity of the Shigella flexneri type III secretion apparatus
Read more01 Mar 2002
publication
Spa15 of Shigella flexneri, a third type of chaperone in the type III secretion pathway
Read more01 Nov 2001
publication
Characterization of the interaction partners of secreted proteins and chaperones of Shigella flexneri
Read more01 Feb 2001
publication
Secretion of predicted Inc proteins of Chlamydia pneumoniae by a heterologous type III machinery
Read more01 Feb 2001
publication
Structure and composition of the Shigella flexneri “needle complex”, a part of its type III secreton
Read more01 Nov 2000
publication
The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri
Read more01 Oct 2000
publication
IpgD, a protein secreted by the type III secretion machinery of Shigella flexneri, is chaperoned by IpgE and implicated in entry focus formation
Read more01 Sep 2000
publication
Characterization of the interaction of IpaB and IpaD, proteins required for entry of Shigella flexneri into epithelial cells, with a lipid membrane
Read more01 Mar 2000
publication
The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread
Read more01 Nov 1999
publication
The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes
Read more01 Sep 1999
publication
The secreted IpaB and IpaC invasins and their cytoplasmic chaperone IpgC are required for intercellular dissemination of Shigella flexneri
Read more01 Jul 1998
publication
SepA, the 110 kDa protein secreted by Shigella flexneri: two-domain structure and proteolytic activity
Read more15 May 1998
publication
Induction of type III secretion in Shigella flexneri is associated with differential control of transcription of genes encoding secreted proteins
Read more01 Oct 1997
publication
Secretion of Ipa proteins by Shigella flexneri: inducer molecules and kinetics of activation
Read more01 May 1997
publication
Functional analysis of the Shigella flexneri IpaC invasin by insertional mutagenesis
Read more01 Mar 1997
publication
SopA, the outer membrane protease responsible for polar localization of IcsA in Shigella flexneri
Read more01 Jan 1997
publication
Purification of IpaC, a protein involved in entry of Shigella flexneri into epithelial cells and characterization of its interaction with lipid membranes
Read more01 Jan 1996
01 Aug 1995
publication
MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination
Read more01 Aug 1995
publication
Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells
Read more01 Jul 1995
publication
SepA, the major extracellular protein of Shigella flexneri: autonomous secretion and involvement in tissue invasion
Read more01 Apr 1995
publication
Enhanced secretion through the Shigella flexneri Mxi-Spa translocon leads to assembly of extracellular proteins into macromolecular structures
Read more01 Dec 1994
publication
Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent
Read more15 Nov 1994
publication
The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD
Read more01 Nov 1994
publication
Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri
Read more01 Jan 1994
publication
Shigella flexneri: genetics of entry and intercellular dissemination in epithelial cells
Read more01 Sep 1993
publication
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells
Read more01 Aug 1993
publication
Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement
Read more01 May 1993
publication
Characterization of the Shigella flexneri ipgD and ipgF genes, which are located in the proximal part of the mxi locus
Read more01 Apr 1993
publication
Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement
Read more01 Jan 1993
publication
MxiD, an outer membrane protein necessary for the secretion of the Shigella flexneri lpa invasins
Read more01 Dec 1992
publication
MxiJ, a lipoprotein involved in secretion of Shigella Ipa invasins, is homologous to YscJ, a secretion factor of the Yersinia Yop proteins
Read more01 Aug 1992
publication
Structural analysis of the acfA and acfD genes of Vibrio cholerae: effects of DNA topology and transcriptional activators on expression
Read more01 Jun 1992
publication
icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread
Read more01 Jan 1992
15 Jun 1991
01 May 1991
publication
Expression of the Vibrio cholerae gene encoding aldehyde dehydrogenase is under control of ToxR, the cholera toxin transcriptional activator
Read more01 Mar 1991
publication
ToxR regulates the production of lipoproteins and the expression of serum resistance in Vibrio cholerae
Read more01 Dec 1990
publication
Expression of ToxR, the transcriptional activator of the virulence factors in Vibrio cholerae, is modulated by the heat shock response
Read more15 Oct 1988
publication
Cloning and nucleotide sequence of the Bacillus subtilis hom gene coding for homoserine dehydrogenase. Structural and evolutionary relationships with Escherichia coli aspartokinases-homoserine dehydrogenases I and II
Read more01 Sep 1988
publication
Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes
Read more01 Sep 1988
publication
Pseudomonas aeruginosa diaminopimelate decarboxylase: evolutionary relationship with other amino acid decarboxylases
Read more01 Jan 1988
publication
Methionine biosynthesis in Enterobacteriaceae: biochemical, regulatory, and evolutionary aspects
Read more01 Sep 1987
publication
Enzyme specialization during the evolution of amino acid biosynthetic pathways
Read more01 Aug 1987
publication
A common origin for enzymes involved in the terminal step of the threonine and tryptophan biosynthetic pathways
Read more01 Jul 1987
publication
Cloning and nucleotide sequence of the thrB gene from the cyanobacterium Calothrix PCC 7601
Read more25 Jun 1987
publication
Nucleotide sequence of the overlapping genes for the subunits of Bacillus subtilis aspartokinase II and their control regions
Read more01 Nov 1986
publication
Evolution of biosynthetic pathways: a common ancestor for threonine synthase, threonine dehydratase and D-serine dehydratase
Read more01 Feb 1986
publication
Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region
Read more25 Jan 1986
publication
Nucleotide sequence of lysC gene encoding the lysine-sensitive aspartokinase III of Escherichia coli K12. Evolutionary pathway leading to three isofunctional enzymes
Read more22 Jul 1985
publication
Two functional domains conserved in major and alternate bacterial sigma factors
Read more11 Nov 1983
publication
Nucleotide sequence of thrC and of the transcription termination region of the threonine operon in Escherichia coli K12
Read more25 Jun 1983
publication
In vitro transcription of the cloned chromosomal crystal gene from Bacillus thuringiensis
Read more01 Jan 1982
publication