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© Research
Publication : Molecular microbiology

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 01 Jun 1992

Allaoui A, Mounier J, Prévost MC, Sansonetti PJ, Parsot C

Link to Pubmed [PMID] – 1495389

Mol. Microbiol. 1992 Jun;6(12):1605-16

Shigella flexneri causes bacillary dysentery by invading epithelial cells of the colonic mucosa. We have characterized the icsB gene which is located on the virulence plasmid pWR100. After inactivation of icsB, the mutant strain remained invasive, but formed abnormally small plaques on HeLa cell monolayers, colonized only the peripheral cells of Caco-2 islets, and was unable to provoke a keratoconjunctivitis in guinea-pigs. Examination of infected HeLa cells showed that the icsB mutant was able to lyse the phagocytic vacuole and to form protrusions at the surface of infected cells, but, unlike the wild type, remained trapped in protrusions surrounded by two membranes. These results indicate that IcsB is involved in the lysis of the protrusions, a step necessary for intercellular spread.

http://www.ncbi.nlm.nih.gov/pubmed/1495389