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© Research
Publication : Molecular microbiology

Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Molecular microbiology - 01 Aug 1995

Hermant D, Ménard R, Arricau N, Parsot C, Popoff MY

Link to Pubmed [PMID] – 8801431

Mol. Microbiol. 1995 Aug;17(4):781-9

A Salmonella typhi chromosomal locus composed of five adjacent genes, designated sipEBCDA, was identified by transposon mutagenesis as being essential for cell invasion. Products of the sip genes exhibit extensive sequence similarities to the effectors of Shigella entry into epithelial cells encoded by the virulence plasmid-borne ipa operon. Expression of sipE and sipB in a Shigella non-invasive ipaB mutant restored the ability to invade epithelial cells. The structural and functional conservation of the Sip and Ipa proteins suggests that Salmonella and Shigella entry processes are promoted by similar effectors.

http://www.ncbi.nlm.nih.gov/pubmed/8801431