Timeline

Michael Nilges

Head of Structure

07 Nov 2024

event

2nd EPFL-Institut Pasteur Symposium in Paris on December 5, 2024

30 Oct 2024

publication

Dynamic interplay between a TonB-dependent heme transporter and a TonB protein in a membrane environment

26 Sep 2024

event

Workshop of The Structural Bioinformatics Unit

05 Jul 2024

publication

Structure and Dynamics of Type 4a Pili and Type 2 Secretion System Endopili

30 Apr 2024

event

Roles of core facilities in institutional and regional R&D&I, and management practices

20 Apr 2024

publication

A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery

25 Aug 2023

event

DBSC workshop “Optimal Prediction of Protein Complex Structures with AlphaFold Made Easy” on September 26th

22 Jun 2023

event

Single-Domain Antibodies 2023

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

27 Jan 2023

event

NMR: a tool for biology XIIIth

13 Sep 2022

publication

Building Protein Atomic Models from Cryo-EM Density Maps and Residue Co-Evolution.

11 Sep 2022

project

Energir: Energy dependent iron import by Gram-negative bacteria

28 Apr 2022

publication

Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.

14 Apr 2022

publication

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.

16 Mar 2022

event

Half-day Latest innovations and Applications in CryoEM& CryoET

15 Dec 2021

publication

InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions.

01 Oct 2021

publication

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

11 Sep 2021

publication

Computational and biochemical analysis of type IV pilus dynamics and stability.

14 Jul 2021

publication

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.

08 Jan 2021

publication

The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators.

22 Jun 2020

event

NMR: a tool for Biology XIIth

21 Apr 2020

tool

ARIAweb: a server for automated NMR structure calculation

19 Nov 2019

event

Thesis defense: Borja Rodriguez de Francisco – “Self-assembly into functional amyloids of Aspergillus fumigatus hydrophobins”

03 Oct 2019

event

Department of Structural Biology and Chemistry seminar: James Conway, Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy

31 Jul 2019

project

Synergy_T2SS

23 May 2019

publication

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

09 Apr 2019

publication

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.

26 Jan 2019

event

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

24 Jan 2019

patent

Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987

01 Jan 2019

publication

Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

18 Dec 2018

publication

Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR.

04 Sep 2018

event

Binless: bayesian normalization of Hi-C data provides significant interaction and difference detection independently of resolution

29 May 2018

event

Half-Day Symposium “NMR Beyond Protein Structures”

16 Mar 2018

publication

Ordering Protein Contact Matrices

09 Mar 2018

publication

Tuning interval Branch-and-Prune for protein structure determination

28 Nov 2017

project

ViBrANT (Viral and Bacterial Adhesin Network Training)

15 May 2017

event

“NMR in drug discovery” – Dr Wolfgang JAHNKE

13 Mar 2017

event

Jane Clarke seminar

10 Mar 2017

event

Pr. Timothy DAFFORN seminar

02 Mar 2016

project

ARIA for hybrid structure determination on the cloud

05 Jan 2016

publication

Structure determination of helical filaments by solid-state NMR spectroscopy

16 Oct 2015

project

AEGIS (Accelerated Early staGe drug dIScovery)

08 Oct 2015

team

Tech Lab

14 Sep 2015

publication

Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation

31 Aug 2015

project

Binding mode of promising antituberculosis clinical compounds to their bacterial target

23 Jul 2015

software

ARIA (Ambiguous Restraints for Iterative Assignment)

22 Jul 2015

project

FiberSpace

22 Jul 2015

publication

Biogenesis and structure of a type VI secretion membrane core complex

07 Jul 2015

project

ERC-2011-AdG BAYCELLS

07 Jul 2015

project

Bip:Bip

07 Jul 2015

project

CACSICE

11 May 2015

team

Structural Bioinformatics

11 Apr 2015

publication

Improved reliability, accuracy and quality in automated NMR structure calculation with ARIA

26 Dec 2014

publication

An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps

14 Sep 2014

publication

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

31 May 2012

publication

Efficient modeling of symmetric protein aggregates from NMR data

01 Jan 2012

publication

ARIA for solution and solid-state NMR

05 May 2011

publication

Grid computing for improving conformational sampling in NMR structure calculation

01 Mar 2011

publication

Bayesian estimation of NMR restraint potential and weight: a validation on a representative set of protein structures

28 Jun 2010

publication

Structural insights into serine-rich fimbriae from Gram-positive bacteria

09 Jun 2010

publication

Simultaneous use of solution, solid-state NMR and X-ray crystallography to study the conformational landscape of the Crh protein during oligomerization and crystallization

15 May 2009

publication

Influence of different assignment conditions on the determination of symmetric homodimeric structures with ARIA

01 Apr 2009

publication

Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation

10 Sep 2008

publication

Accurate NMR structures through minimization of an extended hybrid energy

05 Jun 2008

publication

Graphical analysis of NMR structural quality and interactive contact map of NOE assignments in ARIA

20 Feb 2008

publication

3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints

22 Nov 2006

publication

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei

22 Nov 2006

publication

ARIA2: automated NOE assignment and data integration in NMR structure calculation

01 Sep 2006

publication

Determination of dihedral Psi angles in large proteins by combining NH(N)/C(alpha)H(alpha) dipole/dipole cross-correlation and chemical shifts

01 Mar 2006

publication

Comparison of different torsion angle approaches for NMR structure determination

01 Apr 2005

publication

A little guide for advanced search:

2nd EPFL-Institut Pasteur Symposium in Paris on December 5, 2024

Dynamic interplay between a TonB-dependent heme transporter and a TonB protein in a membrane environment

Workshop of The Structural Bioinformatics Unit

Structure and Dynamics of Type 4a Pili and Type 2 Secretion System Endopili

Roles of core facilities in institutional and regional R&D&I, and management practices

A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery

DBSC workshop “Optimal Prediction of Protein Complex Structures with AlphaFold Made Easy” on September 26th

Single-Domain Antibodies 2023

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

NMR: a tool for biology XIIIth

Building Protein Atomic Models from Cryo-EM Density Maps and Residue Co-Evolution.

Energir: Energy dependent iron import by Gram-negative bacteria

Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.

Bat coronaviruses related to SARS-CoV-2 and infectious for human cells.

Half-day Latest innovations and Applications in CryoEM& CryoET

InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions.

1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system

Computational and biochemical analysis of type IV pilus dynamics and stability.

Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.

The iPPI-DB initiative: a community-centered database of protein-protein interaction modulators.

NMR: a tool for Biology XIIth

ARIAweb: a server for automated NMR structure calculation

Thesis defense: Borja Rodriguez de Francisco – “Self-assembly into functional amyloids of Aspergillus fumigatus hydrophobins”

Department of Structural Biology and Chemistry seminar: James Conway, Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy

Synergy_T2SS

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.

11th Conference “NMR: a tool for Biology”, 28-30 Jan 2019

Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987

Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling

Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR.

Binless: bayesian normalization of Hi-C data provides significant interaction and difference detection independently of resolution

Half-Day Symposium “NMR Beyond Protein Structures”

Ordering Protein Contact Matrices

Tuning interval Branch-and-Prune for protein structure determination

ViBrANT (Viral and Bacterial Adhesin Network Training)

“NMR in drug discovery” – Dr Wolfgang JAHNKE

Jane Clarke seminar

Pr. Timothy DAFFORN seminar

ARIA for hybrid structure determination on the cloud

Structure determination of helical filaments by solid-state NMR spectroscopy

AEGIS (Accelerated Early staGe drug dIScovery)

Tech Lab

Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation

Binding mode of promising antituberculosis clinical compounds to their bacterial target

ARIA (Ambiguous Restraints for Iterative Assignment)

FiberSpace

Biogenesis and structure of a type VI secretion membrane core complex

ERC-2011-AdG BAYCELLS

Bip:Bip

CACSICE

Structural Bioinformatics

Improved reliability, accuracy and quality in automated NMR structure calculation with ARIA

An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps

Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG

Efficient modeling of symmetric protein aggregates from NMR data

ARIA for solution and solid-state NMR

Grid computing for improving conformational sampling in NMR structure calculation

Bayesian estimation of NMR restraint potential and weight: a validation on a representative set of protein structures

Structural insights into serine-rich fimbriae from Gram-positive bacteria

Simultaneous use of solution, solid-state NMR and X-ray crystallography to study the conformational landscape of the Crh protein during oligomerization and crystallization

Influence of different assignment conditions on the determination of symmetric homodimeric structures with ARIA

Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation

Accurate NMR structures through minimization of an extended hybrid energy

Graphical analysis of NMR structural quality and interactive contact map of NOE assignments in ARIA

3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints

Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei

ARIA2: automated NOE assignment and data integration in NMR structure calculation

Determination of dihedral Psi angles in large proteins by combining NH(N)/C(alpha)H(alpha) dipole/dipole cross-correlation and chemical shifts

Comparison of different torsion angle approaches for NMR structure determination

Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism