Ligne de temps
Michael Nilges
Responsable de Structure
20 avr. 2024
publication
A comprehensive dataset of protein-protein interactions and ligand binding pockets for advancing drug discovery.
Lire plus25 août 2023
event
DBSC workshop “Optimal Prediction of Protein Complex Structures with AlphaFold Made Easy” on September 26th
Lire plus22 juin 2023
02 févr. 2023
publication
Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Lire plus01 févr. 2023
news
Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Lire plus27 janv. 2023
13 sept. 2022
publication
Building Protein Atomic Models from Cryo-EM Density Maps and Residue Co-Evolution.
Lire plus11 sept. 2022
project
Energir: Comprendre les mécanismes moléculaires d’acquisition du fer chez les bactéries à Gram-négatif, par une approche intégrative
Lire plus28 avr. 2022
publication
Secondary structure and 1H, 15 N & 13C resonance assignments of the periplasmic domain of OutG, major pseudopilin from Dickeya dadantii type II secretion system.
Lire plus14 avr. 2022
16 mars 2022
15 déc. 2021
publication
InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein-protein interactions.
Lire plus01 oct. 2021
publication
1 H, 15 N and 13 C resonance assignments of the C-terminal domain of PulL, a component of the Klebsiella oxytoca type II secretion system
Lire plus11 sept. 2021
publication
Computational and biochemical analysis of type IV pilus dynamics and stability.
Lire plus14 juil. 2021
publication
Host-Pathogen Adhesion as the Basis of Innovative Diagnostics for Emerging Pathogens.
Lire plus08 janv. 2021
publication
The iPPI-DB initiative: A Community-centered database of Protein-Protein Interaction modulators.
Lire plus22 juin 2020
21 avr. 2020
19 nov. 2019
event
Thesis defense: Borja Rodriguez de Francisco – “Self-assembly into functional amyloids of Aspergillus fumigatus hydrophobins”
Lire plus03 oct. 2019
event
Department of Structural Biology and Chemistry seminar: James Conway, Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy
Lire plus31 juil. 2019
23 mai 2019
publication
Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches
Lire plus09 avr. 2019
publication
Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.
Lire plus26 janv. 2019
24 janv. 2019
patent
Docking method based on saturation transfer difference NMR data, and means for its implementation WO 2019/011987
Lire plus01 janv. 2019
publication
Bayesian Weighing of Electron Cryo-Microscopy Data for Integrative Structural Modeling
Lire plus18 déc. 2018
publication
Target engagement and binding mode of an anti-tuberculosis drug to its bacterial target deciphered in whole living cells by NMR.
Lire plus04 sept. 2018
event
Binless: bayesian normalization of Hi-C data provides significant interaction and difference detection independently of resolution
Lire plus29 mai 2018
16 mars 2018
09 mars 2018
28 nov. 2017
15 mai 2017
13 mars 2017
10 mars 2017
02 mars 2016
05 janv. 2016
16 oct. 2015
08 oct. 2015
14 sept. 2015
publication
Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation
Lire plus31 août 2015
project
Binding mode of promising antituberculosis clinical compounds to their bacterial target
Lire plus23 juil. 2015
22 juil. 2015
22 juil. 2015
07 juil. 2015
07 juil. 2015
07 juil. 2015
11 mai 2015
11 avr. 2015
publication
Improved reliability, accuracy and quality in automated NMR structure calculation with ARIA
Lire plus26 déc. 2014
publication
An automatic tool to analyze and cluster macromolecular conformations based on self-organizing maps
Lire plus14 sept. 2014
publication
Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG
Lire plus31 mai 2012
01 janv. 2012
05 mai 2011
publication
Grid computing for improving conformational sampling in NMR structure calculation
Lire plus01 mars 2011
publication
Bayesian estimation of NMR restraint potential and weight: a validation on a representative set of protein structures
Lire plus28 juin 2010
09 juin 2010
publication
Simultaneous use of solution, solid-state NMR and X-ray crystallography to study the conformational landscape of the Crh protein during oligomerization and crystallization
Lire plus15 mai 2009
publication
Influence of different assignment conditions on the determination of symmetric homodimeric structures with ARIA
Lire plus01 avr. 2009
publication
Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation
Lire plus10 sept. 2008
05 juin 2008
publication
Graphical analysis of NMR structural quality and interactive contact map of NOE assignments in ARIA
Lire plus20 févr. 2008
publication
3D structure determination of the Crh protein from highly ambiguous solid-state NMR restraints
Lire plus22 nov. 2006
publication
ARIA2: automated NOE assignment and data integration in NMR structure calculation
Lire plus22 nov. 2006
publication
Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei
Lire plus01 sept. 2006
publication
Determination of dihedral Psi angles in large proteins by combining NH(N)/C(alpha)H(alpha) dipole/dipole cross-correlation and chemical shifts
Lire plus01 mars 2006
publication
Comparison of different torsion angle approaches for NMR structure determination
Lire plus01 avr. 2005
publication