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© Research
Event

Department of Structural Biology and Chemistry seminar: James Conway, Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
11
Oct 2019
Time
11:30:00
28 Rue du Dr Roux, Paris, France
Address
Building: Roux building Room: Chamberland room
Location
2019-10-11 11:30:00 2019-10-11 13:00:00 Europe/Paris Department of Structural Biology and Chemistry seminar: James Conway, Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy Department of Structural Biology  and Chemistry SEMINAR Vendredi 11 Oct. 2019 at 11:30 Chamberland room Pr. James Conway University of Pittsburgh – USA   Probing the common architectures of bacteriophage T5 and herpesvirus by […] 28 Rue du Dr Roux, Paris, France Michael Nilges michael.nilges@pasteur.fr

About

Department of Structural Biology  and Chemistry

SEMINAR

Vendredi 11 Oct. 2019 at 11:30
Chamberland room

Pr. James Conway
University of Pittsburgh – USA

 

Probing the common architectures of bacteriophage T5 and herpesvirus by cryo-electron microscopy

 

The capsid protein fold of double-stranded DNA tailed bacteriophages was first detailed for phage HK97 and has since been observed in all members of this extraordinarily diverse and large family of viruses. For the past 15 years we have also been studying phage T5 whose capsid is larger than that of HK97 and offers insights into how the common fold of the major capsid protein can be directed to different icosahedral geometries. The tractability of these phage systems has been instrumental in understanding the architecture of the more directly biomedically important herpesvirus capsid, where the much larger major capsid protein also adopts the HK97 fold, and in particular in understanding the structure of the unique DNA-packaging vertex. Advances in cryo-electron microscopy have had a major impact on these studies and recent results on the capsid structures of both phage T5 and herpesvirus will be reviewed.

 

 

Contact: michael.nilges@pasteur.fr or matthijn.vos@pasteur.fr
Structural Bioinformatics
Nanoimaging Core Facility

Location

Building: Roux building
Room: Chamberland room
Address: 28 Rue du Dr Roux, Paris, France