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© Research
Event

“NMR in drug discovery” – Dr Wolfgang JAHNKE

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
20
Jun 2017
Time
11:00:00
25 Rue du Docteur Roux, Paris, France
Address
Building: LWOFF
Location
2017-06-20 11:00:00 2017-06-20 00:00:00 Europe/Paris “NMR in drug discovery” – Dr Wolfgang JAHNKE Séminaire du Département de Biologie Structurale & Chimie Dr Wolfgang JAHNKE (Novartis Institutes for Biomedical Research Chemical Biology and Therapeutics, Basel, Switzerland) “NMR in drug discovery” NMR spectroscopy not only is a powerful method […] 25 Rue du Docteur Roux, Paris, France Michael Nilges michael.nilges@pasteur.fr

About

Séminaire du Département de Biologie Structurale & Chimie

Dr Wolfgang JAHNKE

(Novartis Institutes for Biomedical Research Chemical Biology and Therapeutics, Basel, Switzerland)

“NMR in drug discovery”

NMR spectroscopy not only is a powerful method for structure determination, but also a robust biophysical method to detect and characterize even weak protein-ligand interactions. This makes NMR a very useful tool for drug discovery. Hit finding by NMR fragment screening can yield lead compounds even for difficult targets, and the hits can be characterized with respect to binding site and binding mode. Some applications of NMR in drug discovery will be shown, including the NMR-assisted identification of ABL001, an allosteric inhibitor of BCR-ABL kinase that is currently in clinical trials.

Contacts: Michael NILGES

michael.nilges@pasteur.fr

Location

Building: LWOFF
Address: 25 Rue du Docteur Roux, Paris, France