Timeline

Vishu Kumar Aimanianda Bopaiah

Group Leader

18 Mar 2024

event

Symposium “Microbial Cell Wall” ; Monday, June 3rd ; Jules Bordet room

06 Feb 2024

news

Focus on Sarah Dellière (Immunobiology of Aspergillus) on Pasteur.fr

06 Feb 2024

project

Priming mosquito immunity with fungus: a novel strategy to reduce mosquito vector competence

19 Jan 2024

news

Highlighted paper: “Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis” Raffael Junio Araujo de Castro et al. (2023)

30 Nov 2023

publication

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis.

22 Sep 2023

event

PhD Defense: Sarah Dellière (Immunobiology of Aspergillus group, Mycology dpt) “Role of humoral immunity against Aspergillus fumigatus” ; Thursday 28 September @2.30 pm ; Jules Bordet room

16 Jun 2023

publication

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.

08 Jun 2023

publication

Humoral Immunity Against Aspergillus fumigatus.

01 Jun 2023

publication

Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens.

01 Jun 2023

publication

Invasive aspergillosis in liver transplant recipients.

01 Apr 2023

publication

Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.

28 Feb 2023

publication

What Is New in Pulmonary Mucormycosis?

07 Feb 2023

publication

Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition.

24 Jan 2023

publication

Conidium Specific Polysaccharides in Aspergillus fumigatus.

01 Dec 2022

publication

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus.

15 Apr 2022

publication

Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium

14 Feb 2022

publication

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

25 Jan 2022

news

Highlighted Publication: ” Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus” Wong et al.; The Cell Surface; Molecular Mycology’s team

01 Jan 2022

publication

CT295 Is Chlamydia trachomatis’ Phosphoglucomutase and a Type 3 Secretion Substrate.

01 Jan 2022

publication

Protective role of host complement system in Aspergillus fumigatus infection.

01 Dec 2021

project

FUNPOLYVAC – Exploring fungal cell-wall polysaccharides for immunotherapies

01 Dec 2021

project

ANR-DFG project : Proteome and polysaccharidome of Aspergillus fumigatus at early stage of infection

16 Nov 2021

publication

Wnt-β-Catenin Signaling in Human Dendritic Cells Mediates Regulatory T-Cell Responses to Fungi via the PD-L1 Pathway.

01 Nov 2021

publication

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency.

26 Oct 2021

publication

Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus.

14 Sep 2021

course

MOOC Medical Mycology

10 Sep 2021

news

New Highlighted publication: “Cryptococcus extracellular vesicles properties and their use as vaccine platforms”, Juliana Rizzo et al. JEV, 2021, RNA Biology of Fungal Pathogen team

01 Aug 2021

publication

Cryptococcus extracellular vesicles properties and their use as vaccine platforms.

27 Jul 2021

publication

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.

26 Jul 2021

news

ANR PRC call : Congratulations to Vishu Kumar Aimanianda and Thierry Fontaine for their successful project proposal “FUNPOLYVAC”

01 Jan 2021

publication

Complement-Mediated Differential Immune Response of Human Macrophages to Sporothrix Species Through Interaction With Their Cell Wall Peptidorhamnomannans.

01 Jan 2021

publication

Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two Aspergillus, Aspergillus fumigatus and A. flavus.

01 Jan 2021

publication

Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus.

19 Oct 2020

team

Immunobiology of Aspergillus

26 Aug 2020

publication

The Role of RodA-Conserved Cysteine Residues in the Aspergillus fumigatus Conidial Surface Organization.

19 Aug 2020

publication

Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus.

27 Jun 2020

publication

Soluble mediators in anti-fungal immunity.

16 Jun 2020

publication

Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect.

02 Jun 2020

publication

Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca2+-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of Aspergillus fumigatus.

08 May 2020

publication

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.

01 Jan 2020

publication

Aspergillus fumigatus Infection in Humans With STAT3-Deficiency Is Associated With Defective Interferon-Gamma and Th17 Responses.

01 Jan 2020

publication

Editorial: The Role of the Fungal Cell Wall in Host-Fungal Interactions.

01 Dec 2019

publication

Assembly and disassembly of Aspergillus fumigatus conidial rodlets

10 Sep 2019

event

The fungal cell wall – organization and role during host-pathogen interaction -Vishu AIMANIANDIA BOPAIAH

19 Jun 2019

publication

β-Glucan Grafted Microcapsule, a Tool for Studying the Immunomodulatory Effect of Microbial Cell Wall Polysaccharides.

01 May 2019

publication

The puzzling construction of the conidial outer layer of Aspergillus fumigatus.

06 Mar 2019

event

“Novel aspects of host-pathogen interactions – the case of the human-pathogenic fungus Aspergillus fumigatus” – Axel Brakhage

01 Jan 2019

publication

Novel mouse monoclonal antibodies specifically recognizing β-(1→3)-D-glucan antigen.

16 Oct 2018

publication

Chemical Synthesis and Application of Biotinylated Oligo-α-(1 → 3)-d-Glucosides To Study the Antibody and Cytokine Response against the Cell Wall α-(1 → 3)-d-Glucan of Aspergillus fumigatus.

23 Aug 2018

publication

Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.

24 Jul 2018

project

Pathogenic Aspergillus: Interaction with innate immune cells

24 Jul 2018

project

Hydrophobin: functional amyloids from the fungal pathogen Aspergillus fumigatus

28 Feb 2018

publication

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

05 Feb 2018

publication

Fungal melanin stimulates surfactant protein D-mediated opsonization of and host immune response to spores

05 Jan 2018

publication

Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles

24 Dec 2017

publication

Host Soluble Mediators: Defying the Immunological Inertness of Conidia

05 Dec 2017

publication

Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells

21 Jul 2017

publication

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

20 Jun 2017

publication

The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall

11 Oct 2016

publication

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus

15 Jun 2016

publication

GH16 and GH81 family β-(1,3)-glucanases in Aspergillus fumigatus are essential for conidial cell wall morphogenesis

31 May 2016

publication

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

06 Oct 2015

project

COMASPIN

01 Apr 2015

publication

(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus

30 Dec 2014

publication

Aspergillus fumigatus devoid of cell wall β-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors

05 Nov 2014

publication

Synthesis of a pentasaccharide and neoglycoconjugates related to fungal α-(1→3)-glucan and their use in the generation of antibodies to trace Aspergillus fumigatus cell wall

15 Aug 2014

publication

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

20 Jun 2014

publication

Aspergillus cell wall and biofilm

12 May 2014

publication

Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response

07 Aug 2013

publication

The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo

16 Jul 2013

publication

Unraveling the nanoscale surface properties of chitin synthase mutants of Aspergillus fumigatus and their biological implications

18 Mar 2013

publication

SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis

01 Feb 2013

publication

Circulating human basophils lack the features of professional antigen presenting cells

01 Jan 2013

publication

Undressing the fungal cell wall/cell membrane–the antifungal drug targets

04 Dec 2012

publication

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

10 Sep 2012

publication

Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins

31 May 2012

publication

Hydrophobins–unique fungal proteins

20 Oct 2011

publication

HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus

01 Jan 2011

publication

The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR)

22 Dec 2010

publication

Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus

29 Nov 2010

publication

The Candida albicans Sur7 protein is needed for proper synthesis of the fibrillar component of the cell wall that confers strength

07 Jul 2010

publication

Characterization of the GPI-anchored endo β-1,3-glucanase Eng2 of Aspergillus fumigatus

01 Jul 2010

publication

Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus.

01 May 2010

publication

Fungal hydrophobins form a sheath preventing immune recognition of airborne conidia

29 Apr 2010

publication

Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA

14 Apr 2010

publication

Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability

01 Apr 2010

publication

Problems and hopes in the development of drugs targeting the fungal cell wall

16 Nov 2009

publication

Aspergillus fumigatus LaeA-mediated phagocytosis is associated with a decreased hydrophobin layer

27 Aug 2009

publication

Surface hydrophobin prevents immune recognition of airborne fungal spores

19 Aug 2009

publication

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors

01 Jun 2009

publication

Aspergillus fumigatus: cell wall polysaccharides, their biosynthesis and organization

11 May 2009

publication

Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants

11 Mar 2009

publication

Cell wall beta-(1,6)-glucan of Saccharomyces cerevisiae: structural characterization and in situ synthesis

09 Jan 2009

publication

A role for the unfolded protein response (UPR) in virulence and antifungal susceptibility in Aspergillus fumigatus

21 Jul 2008

publication

Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins

27 Jan 2007

publication

Low molecular weight chitosan–preparation with the aid of pepsin, characterization, and its bactericidal activity

20 Dec 2006

publication

Low molecular weight chitosans–preparation with the aid of pronase, characterization and their bactericidal activity towards Bacillus cereus and Escherichia coli

15 Oct 2005

publication

Characterization of chito-oligosaccharides prepared by chitosanolysis with the aid of papain and Pronase, and their bactericidal action against Bacillus cereus and Escherichia coli

01 May 2005

publication

Chitooligosaccharides–preparation with the aid of pectinase isozyme from Aspergillus niger and their antibacterial activity

01 Feb 2004

publication

Non-specific depolymerization of chitosan by pronase and characterization of the resultant products

22 Jan 2004

publication

Low molecular weight chitosans: preparation with the aid of papain and characterization

16 Jun 2003

publication

Low molecular weight chitosans–preparation by depolymerization with Aspergillus niger pectinase, and characterization

01 Dec 1997

publication

A little guide for advanced search:

Symposium “Microbial Cell Wall” ; Monday, June 3rd ; Jules Bordet room

Focus on Sarah Dellière (Immunobiology of Aspergillus) on Pasteur.fr

Priming mosquito immunity with fungus: a novel strategy to reduce mosquito vector competence

Highlighted paper: “Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis” Raffael Junio Araujo de Castro et al. (2023)

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis.

PhD Defense: Sarah Dellière (Immunobiology of Aspergillus group, Mycology dpt) “Role of humoral immunity against Aspergillus fumigatus” ; Thursday 28 September @2.30 pm ; Jules Bordet room

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates.

Humoral Immunity Against Aspergillus fumigatus.

Comparative proteome analysis identifies species-specific signature proteins in Aspergillus pathogens.

Invasive aspergillosis in liver transplant recipients.

Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis.

What Is New in Pulmonary Mucormycosis?

Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition.

Conidium Specific Polysaccharides in Aspergillus fumigatus.

Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus.

Genetics and immunity of Anopheles response to the entomopathogenic fungus Metarhizium anisopliae overlap with immunity to Plasmodium

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

Highlighted Publication: ” Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus” Wong et al.; The Cell Surface; Molecular Mycology’s team

CT295 Is Chlamydia trachomatis’ Phosphoglucomutase and a Type 3 Secretion Substrate.

Protective role of host complement system in Aspergillus fumigatus infection.

FUNPOLYVAC – Exploring fungal cell-wall polysaccharides for immunotherapies

ANR-DFG project : Proteome and polysaccharidome of Aspergillus fumigatus at early stage of infection

Wnt-β-Catenin Signaling in Human Dendritic Cells Mediates Regulatory T-Cell Responses to Fungi via the PD-L1 Pathway.

Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency.

Pleiotropic Effects of the P5-Type ATPase SpfA on Stress Response Networks Contribute to Virulence in the Pathogenic Mold Aspergillus fumigatus.

MOOC Medical Mycology

New Highlighted publication: “Cryptococcus extracellular vesicles properties and their use as vaccine platforms”, Juliana Rizzo et al. JEV, 2021, RNA Biology of Fungal Pathogen team

Cryptococcus extracellular vesicles properties and their use as vaccine platforms.

Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity.

ANR PRC call : Congratulations to Vishu Kumar Aimanianda and Thierry Fontaine for their successful project proposal “FUNPOLYVAC”

Complement-Mediated Differential Immune Response of Human Macrophages to Sporothrix Species Through Interaction With Their Cell Wall Peptidorhamnomannans.

Species-Specific Immunological Reactivities Depend on the Cell-Wall Organization of the Two Aspergillus, Aspergillus fumigatus and A. flavus.

Proteomic Analysis of Humoral Immune Components in Bronchoalveolar Lavage of Patients Infected or Colonized by Aspergillus fumigatus.

Immunobiology of Aspergillus

The Role of RodA-Conserved Cysteine Residues in the Aspergillus fumigatus Conidial Surface Organization.

Differential Interactions of Serum and Bronchoalveolar Lavage Fluid Complement Proteins with Conidia of Airborne Fungal Pathogen Aspergillus fumigatus.

Soluble mediators in anti-fungal immunity.

Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect.

Functional Coupling between the Unfolded Protein Response and Endoplasmic Reticulum/Golgi Ca2+-ATPases Promotes Stress Tolerance, Cell Wall Biosynthesis, and Virulence of Aspergillus fumigatus.

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.

Aspergillus fumigatus Infection in Humans With STAT3-Deficiency Is Associated With Defective Interferon-Gamma and Th17 Responses.

Editorial: The Role of the Fungal Cell Wall in Host-Fungal Interactions.

Assembly and disassembly of Aspergillus fumigatus conidial rodlets

The fungal cell wall – organization and role during host-pathogen interaction -Vishu AIMANIANDIA BOPAIAH

β-Glucan Grafted Microcapsule, a Tool for Studying the Immunomodulatory Effect of Microbial Cell Wall Polysaccharides.

The puzzling construction of the conidial outer layer of Aspergillus fumigatus.

“Novel aspects of host-pathogen interactions – the case of the human-pathogenic fungus Aspergillus fumigatus” – Axel Brakhage

Novel mouse monoclonal antibodies specifically recognizing β-(1→3)-D-glucan antigen.

Chemical Synthesis and Application of Biotinylated Oligo-α-(1 → 3)-d-Glucosides To Study the Antibody and Cytokine Response against the Cell Wall α-(1 → 3)-d-Glucan of Aspergillus fumigatus.

Aspergillus fumigatus conidial metalloprotease Mep1p cleaves host complement proteins.

Pathogenic Aspergillus: Interaction with innate immune cells

Hydrophobin: functional amyloids from the fungal pathogen Aspergillus fumigatus

Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus

Fungal melanin stimulates surfactant protein D-mediated opsonization of and host immune response to spores

Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles

Host Soluble Mediators: Defying the Immunological Inertness of Conidia

Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells

MybA, a transcription factor involved in conidiation and conidial viability of the human pathogen Aspergillus fumigatus

The Dual Activity Responsible for the Elongation and Branching of β-(1,3)-Glucan in the Fungal Cell Wall

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus

GH16 and GH81 family β-(1,3)-glucanases in Aspergillus fumigatus are essential for conidial cell wall morphogenesis

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

COMASPIN

(1)H, (13)C and (15)N resonance assignments of the RodA hydrophobin from the opportunistic pathogen Aspergillus fumigatus

Aspergillus fumigatus devoid of cell wall β-1,3-glucan is viable, massively sheds galactomannan and is killed by septum formation inhibitors

Synthesis of a pentasaccharide and neoglycoconjugates related to fungal α-(1→3)-glucan and their use in the generation of antibodies to trace Aspergillus fumigatus cell wall

Deciphering the role of the chitin synthase families 1 and 2 in the in vivo and in vitro growth of Aspergillus fumigatus by multiple gene targeting deletion

Aspergillus cell wall and biofilm

Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response

The RodA hydrophobin on Aspergillus fumigatus spores masks dectin-1- and dectin-2-dependent responses and enhances fungal survival in vivo

Unraveling the nanoscale surface properties of chitin synthase mutants of Aspergillus fumigatus and their biological implications

SUN proteins belong to a novel family of β-(1,3)-glucan-modifying enzymes involved in fungal morphogenesis

Circulating human basophils lack the features of professional antigen presenting cells

Undressing the fungal cell wall/cell membrane–the antifungal drug targets

Hypoxia enhances innate immune activation to Aspergillus fumigatus through cell wall modulation

Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins

Hydrophobins–unique fungal proteins

HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus

The virulence of the opportunistic fungal pathogen Aspergillus fumigatus requires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR)