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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
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© Ce graphique présente, pour chaque date d'observation depuis 2018, le taux d'accès ouvert des publications scientifiques de l'Institut Pasteur, avec un DOI Crossref, parues durant l'année précédente.
News

Highlighted paper: “Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis” Raffael Junio Araujo de Castro et al. (2023)

In a recent issue of PLOS Pathogens, the team of Alexandre Alanio of the National reference center for invasive Mycoses and Antifungals describe how macrophages participate in the dissemination of the deadly fungus Cryptococcus neoformans.

Macrophages were already known to serve as reservoir for the dormant yeast. The present study highlight their role in reactivating a subset of dormant yeasts and in their spreading in the host.

Authors show that C. neoformans maintain macrophages in a non-activated, non-inflammatory state which release some extracellular vesicles that promote the excretion of reactivated C. neoformans cells by non-lytic exocytosis. This study contributes to the understanding of the pathophysiology of cryptococcosis and potentially other latent infections

read more here : https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011841#abstract1