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© A. Alanio, E. Perret
Prolifération de Cryptococcus neoformans dans des macrophages murins.
News

Highlighted Publication: ” Surfactant protein D inhibits growth, alters cell surface polysaccharide exposure and immune activation potential of Aspergillus fumigatus” Wong et al.; The Cell Surface; Molecular Mycology’s team

In this article published in The Cell Surface in December 2021, the group led by Vishu Kumar Amanandia from the Molecular Mycology team addresses the role of Surfactant protein (SP-D) in the humoral response to Aspergillus fumigatus infection.

Wong et al., show that SP-D ,a C-type lectin and a major humoral immune component in the human lung-alveoli,  inhibits Aspergillus fumigatus, an airborne opportunistic fungal pathogen growth in lung alveoli. This fungistatic effect is achieved through a modification of the surface structure of A. fumigatus hyphea thereby inhibiting their growth.

A. fumigatus hyphae grown in presence of SP-D stimulate significantly lower secretions of pro-inflammatory cytokine, but higher anti-inflammatory cytokine and chemokine secretions upon interaction with immune cells, compared to hyphae grown without SP-D.

Of interest, increased permeability of A. fumigatus hyphae upon SP-D treatment leads to a better efficacy of voriconazole, an antifungal drug that has its target in the fungal cytosol.