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© Marie-Christine Prévost, Anne Derbise
Bactéries Yersinia pestis en microscopie electronique à balayage.
Publication : Cellular microbiology

Biosynthesis of cell wall mannan in the conidium and the mycelium of Aspergillus fumigatus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cellular microbiology - 11 Oct 2016

Henry C, Fontaine T, Heddergott C, Robinet P, Aimanianda V, Beau R, Beauvais A, Mouyna I, Prevost MC, Fekkar A, Zhao Y, Perlin D, Latgé JP

Link to Pubmed [PMID] – 27603677

Cell. Microbiol. 2016 Dec;18(12):1881-1891

The galactomannan is a major cell wall molecule of Aspergillus fumigatus. This molecule is composed of a linear mannan with a repeating unit composed of four α1,6 and α1,2 linked mannose with side chains of galactofuran. To obtain a better understanding of the mannan biosynthesis in A. fumigatus, it was decided to undertake the successive deletion of the 11 genes which are putative orthologs of the mannosyltransferases responsible for establishing α1,6 and α1,2 mannose linkages in yeast. These deletions did not lead to a reduction of the mannan content of the cell wall of the mycelium of A. fumigatus. In contrast, the mannan content of the conidial cell wall was reduced and this reduction was associated with a partial disorganization of the cell wall leading to defects in conidial survival both in vitro and in vivo.

https://www.ncbi.nlm.nih.gov/pubmed/27603677