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© Vishu Aimanianda, Institut Pasteur
Cryptococcus neoformans with chitin (blue) and capsule (green) labelings
Event

“Novel aspects of host-pathogen interactions – the case of the human-pathogenic fungus Aspergillus fumigatus” – Axel Brakhage

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
28
Mar 2019
Time
12:00:00
Institut Pasteur, Rue du Docteur Roux, Paris, France
Address
Building: Centre François Jacob Room: Auditorium François Jacob
Location
2019-03-28 12:00:00 2019-03-28 13:00:00 Europe/Paris “Novel aspects of host-pathogen interactions – the case of the human-pathogenic fungus Aspergillus fumigatus” – Axel Brakhage Axel Brakhage – Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll Institute (HKI) Jena Germany) Aspergillus fumigatus represents the most important air-borne fungal pathogen. Life-threatening invasive aspergillosis affects about 200.000 patients […] Institut Pasteur, Rue du Docteur Roux, Paris, France Vishu Kumar Aimanianda Bopaiah kumar-vishu.aimanianda-bopaiah@pasteur.fr

About

Axel Brakhage – Leibniz Institute for Natural Product Research and Infection Biology – Hans-Knöll Institute (HKI) Jena Germany)

Aspergillus fumigatus represents the most important air-borne fungal pathogen. Life-threatening invasive aspergillosis affects about 200.000 patients every year. Upon inhalation of spores, innate immunity plays a major role for defense, in particular neutrophilic granulocytes and alveolar macrophages.

In my laboratory we are interested in fungal virulence determinants including secondary metabolites and immune evasion mechanisms. We use proteome, transcriptome and metabolome analyses to describe the host pathogen interaction. In my talk, I will focus on recent findings concerning the interaction of surface molecules with immune cells and in particular the meaning of lipid raft microdomains for immunity against A. fumigatus. In addition, I will discuss the formation of antifungal extracellular vesicles produced by neutrophils for defense against A. fumigatus.

Contact : Vishu Kumar Aimanianda Bopaiah (kumar-vishu.aimanianda-bopaiah@pasteur.fr)

Location

Building: Centre François Jacob
Room: Auditorium François Jacob
Address: Institut Pasteur, Rue du Docteur Roux, Paris, France