Timeline
Caroline Demangel
Head of Structure
17 Jan 2024
17 Jan 2024
17 Jan 2024
23 Nov 2023
publication
Host-pathogen interactions from a metabolic perspective: methods of investigation.
Read more30 May 2023
publication
From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone.
Read more18 May 2023
24 Mar 2023
publication
Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity.
Read more24 Jan 2023
publication
Click-chemistry-based protocol to quantitatively assess fatty acid uptake by Mycobacterium tuberculosis in axenic culture and inside mouse macrophages.
Read more01 Jan 2023
publication
Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma.
Read more25 Oct 2022
07 Mar 2022
11 Jan 2022
news
New publication – The Sec61 translocon is a therapeutic vulnerability in multiple myeloma
Read more01 Jan 2022
publication
Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples.
Read more01 Jan 2022
publication
Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61.
Read more24 Dec 2021
publication
De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis.
Read more01 Sep 2021
publication
Insights into the ancestry evolution of the Mycobacterium tuberculosis complex from analysis of Mycobacterium riyadhense.
Read more04 May 2021
19 Feb 2021
08 Feb 2021
publication
Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis.
Read more01 Jan 2021
publication
Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone.
Read more01 Jan 2021
publication
Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities.
Read more17 Dec 2020
11 Dec 2020
publication
Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system.
Read more01 Dec 2020
publication
Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system.
Read more23 Oct 2020
publication
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
Read more16 Oct 2020
02 Oct 2020
publication
Mycolactone induces cell death by SETD1B-dependent degradation of glutathione.
Read more24 Sep 2020
publication
Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.
Read more10 Aug 2020
17 Dec 2019
publication
CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy
Read more01 Sep 2019
publication
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Read more30 Aug 2019
event
Department of Immunology seminar: Harry Sokol, Gut Microbiome, intestinal inflammation and Tryptophan Metabolism
Read more17 Jun 2019
21 May 2019
event
Department of Immunology seminar: Alan Korman, Tumor Immunotherapy and a pH Selective Pathway for Immune Regulation
Read more06 May 2019
28 Jul 2018
27 Jul 2018
publication
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Read more18 Jun 2018
publication
Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature
Read more17 Nov 2017
07 Oct 2017
20 Sep 2017
05 Jul 2017
publication
Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export
Read more14 Jun 2017
publication
Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells.
Read more06 Apr 2017
18 Mar 2017
publication
Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids
Read more12 Dec 2016
25 Oct 2016
30 Sep 2016
06 Sep 2016
publication
Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses.
Read more07 Jun 2016
event
Seminaire conjoint du departement d’immunologie et departement de biologie du développement & cellules souches
Read more27 May 2016
04 Dec 2015
07 Aug 2015
27 May 2015
11 May 2015
11 May 2015
15 Sep 2014
02 Sep 2014
publication
Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins
Read more01 Aug 2014
publication
Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings
Read more10 Apr 2014
publication
Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease.
Read more21 Jan 2014
publication
Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens
Read more02 Jul 2013
publication
Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected]
Read more15 Mar 2013
publication
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
Read more01 Jun 2012
publication
Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer
Read more08 May 2012
publication
ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria
Read more30 Nov 2011
publication
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins
Read more19 Jul 2011
publication
Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring
Read more18 Jul 2011
publication
Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression.
Read more21 Oct 2010
publication
Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes
Read more01 Dec 2009
publication
Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease
Read more26 May 2009
publication
Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression
Read more07 Feb 2009
01 Jan 2009
publication
Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans
Read more22 Oct 2008
publication
Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs
Read more17 Apr 2008
publication
Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria
Read more23 Nov 2007
21 May 2007
publication
Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone
Read more01 Sep 2006
publication
Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence
Read more26 May 2006
24 May 2006
publication
Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer
Read more01 Jan 2006
publication
Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence
Read more01 Jan 2006
01 Aug 2005
01 Aug 2005
publication
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin
Read more01 Apr 2005
publication
Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens
Read more10 Dec 2004
publication
Single chain antibody fragments for the selective targeting of antigens to dendritic cells
Read more15 Jun 2004
publication
Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy.
Read more01 Apr 2004
publication
Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6
Read more14 Apr 2003
publication
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis
Read more01 May 2002
publication
TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection
Read more01 Apr 2002
publication
Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production
Read more01 Aug 2001
publication
Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism
Read more01 Jun 2001
publication
Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis
Read more01 Apr 2001
publication
Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope
Read more01 Apr 2001
publication
Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection
Read more01 Aug 2000
01 Apr 2000
publication
Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis
Read more01 Apr 2000
publication
Combining phage display and molecular modeling to map the epitope of a neutralizing antitoxin antibody
Read more01 Jun 1999
publication
Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guérin-infected dendritic cells
Read more01 May 1999
publication
Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin
Read more01 Jan 1998
publication
Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate
Read more01 Sep 1997
01 Jun 1997
publication
Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library
Read more01 Aug 1996
publication
Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library
Read more01 Jan 1993
publication
An attempt to correlate cattle breed origins and diseases associated with or transmitted by the tick Amblyomma variegatum in the French West Indies
Read more01 Sep 1992
publication
Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium [corrected]
Read more01 Jun 1992
publication
Role of metabolic waste products in the control of cell proliferation and antibody production by mouse hybridoma cells
Read more01 Sep 1991
publication
Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply
Read more01 Dec 1990