Timeline

Caroline Demangel
Head of Structure
13 Sep 2019
publication

A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals

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30 Aug 2019
event

Department of Immunology seminar: Harry Sokol, Gut Microbiome, intestinal inflammation and Tryptophan Metabolism

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17 Jun 2019
publication

Recombinant Antibodies against Mycolactone

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21 May 2019
event

Department of Immunology seminar: Alan Korman, Tumor Immunotherapy and a pH Selective Pathway for Immune Regulation

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06 May 2019
publication

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

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28 Jul 2018
publication

Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease

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27 Jul 2018
publication

Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

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18 Jun 2018
publication

Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature

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19 Jan 2018
publication

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

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17 Nov 2017
publication

Mycolactone displays anti-inflammatory effects on the nervous system

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07 Oct 2017
news

Microbes, Immunity and Metabolism international conference, November 15th-17th, 2017

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20 Sep 2017
publication

Modular total syntheses of mycolactone A/B and its [(2)H]-isotopologue

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05 Jul 2017
publication

Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export

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04 May 2017
publication

Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells

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06 Apr 2017
event

MIM 2017 “Microbes, Immunity and Metabolism international conference”

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18 Mar 2017
publication

Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids

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07 Nov 2016
publication

Mycolactone subverts immunity by selectively blocking the Sec61 translocon

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25 Oct 2016
event

Department of Immunology seminar: Oliver Neyrolles

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30 Sep 2016
event

Jonathan Kagan seminar

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25 Aug 2016
publication

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

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07 Jun 2016
event

Seminaire conjoint du departement d’immunologie et departement de biologie du développement & cellules souches

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27 May 2016
event

Immunology department seminar

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04 Dec 2015
publication

Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease

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07 Aug 2015
project

Therapeutic potential of mycolactone surrogates

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07 Aug 2015
project

Mycolactone of M. ulcerans and immunodulation

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07 Aug 2015
project

Biomarkers of Buruli ulcer disease

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01 Jul 2015
project

Mycobacterial phenolic glycolipids and innate host defenses

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01 Jul 2015
project

Mycolactone of M. ulcerans and the actin cytoskeleton

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27 May 2015
publication

Shaping mycolactone for therapeutic use against inflammatory disorders

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11 May 2015
team

Integrated Mycobacterial Pathogenomics

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11 May 2015
team

Immunobiology of Infection

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15 Sep 2014
department

Immunology

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02 Sep 2014
publication

Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins

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01 Aug 2014
publication

Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings

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10 Apr 2014
publication

Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease

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21 Jan 2014
publication

Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens

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02 Jul 2013
publication

Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected]

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15 Mar 2013
publication

Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

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01 Jun 2012
publication

Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer

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08 May 2012
publication

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria

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30 Nov 2011
publication

A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins

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19 Jul 2011
publication

Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring

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18 Jul 2011
publication

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

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18 Nov 2010
publication

Entrapment of intracytosolic bacteria by septin cage-like structures

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21 Oct 2010
publication

Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes

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30 Dec 2009
publication

Mycolactone suppresses T cell responsiveness by altering both early signaling and posttranslational events

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01 Dec 2009
publication

Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease

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26 May 2009
publication

Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression

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07 Feb 2009
publication

Buruli ulcer disease: prospects for a vaccine

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01 Jan 2009
publication

Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans

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22 Oct 2008
publication

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs

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17 Apr 2008
publication

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria

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23 Nov 2007
publication

A novel mycolactone toxin obtained by biosynthetic engineering

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21 May 2007
publication

Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone

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01 Sep 2006
publication

Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence

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26 May 2006
publication

Towards an immunodiagnostic test for leprosy

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24 May 2006
publication

Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer

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01 Jan 2006
publication

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence

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01 Jan 2006
publication

Antigen discovery: a postgenomic approach to leprosy diagnosis

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01 Aug 2005
publication

Tuberculosis: from genome to vaccine

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01 Aug 2005
publication

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin

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01 Apr 2005
publication

Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens

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10 Dec 2004
publication

Single chain antibody fragments for the selective targeting of antigens to dendritic cells

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15 Jun 2004
publication

Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy

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01 Apr 2004
publication

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6

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14 Apr 2003
publication

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

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01 May 2002
publication

TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection

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01 Apr 2002
publication

Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production

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01 Aug 2001
publication

Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism

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01 Jun 2001
publication

Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis

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01 Apr 2001
publication

Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope

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01 Apr 2001
publication

Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection

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01 Aug 2000
publication

Interaction of dendritic cells with mycobacteria: where the action starts

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01 Apr 2000
publication

Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis

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01 Apr 2000
publication

Combining phage display and molecular modeling to map the epitope of a neutralizing antitoxin antibody

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01 Jun 1999
publication

Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guérin-infected dendritic cells

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01 May 1999
publication

Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin

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01 Jan 1998
publication

Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate

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01 Sep 1997
publication

Phage-displayed and soluble mouse scFv fragments neutralize rabies virus

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01 Jun 1997
publication

Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library

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01 Aug 1996
publication

Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library

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01 Jan 1993
publication

An attempt to correlate cattle breed origins and diseases associated with or transmitted by the tick Amblyomma variegatum in the French West Indies

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01 Sep 1992
publication

Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium [corrected]

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01 Jun 1992
publication

Role of metabolic waste products in the control of cell proliferation and antibody production by mouse hybridoma cells

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01 Sep 1991
publication

Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply

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01 Dec 1990
publication

Comparison of various methods for monitoring hybridoma cell proliferation

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