Timeline

Anne Dejean
Head of Structure
17 Sep 2023
publication
Generation of embryo-like structures from mouse embryonic stem cells treated with a chemical inhibitor of SUMOylation and cultured in microdroplets
Read more26 May 2023
news
New publication – Transient suppression of SUMOylation in embryonic stem cells generates embryo like structures
Read more17 May 2023
15 Apr 2023
publication
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
Read more06 Oct 2021
project
Integrating the activities of SUMO in gene expression, inflammation and cancer (ERC-2011-AdG SUMOSTRESS)
Read more06 Oct 2021
01 Sep 2021
02 Mar 2021
publication
Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry
Read more23 Sep 2020
publication
SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes.
Read more18 Sep 2020
publication
An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency.
Read more15 Sep 2020
publication
Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells.
Read more18 Feb 2020
publication
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells
Read more18 Jul 2019
project
Deconstructing the role of SUMO on chromatin in cell identity and tissue repair (ERC-2018-AdG SUMiDENTITY)
Read more22 Oct 2018
publication
SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states
Read more13 Aug 2018
publication
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden
Read more12 Dec 2017
publication
entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation
Read more06 Dec 2017
publication
Shigella entry unveals a calcium/calpain-dependent mechanism for inhibiting sumoylation
Read more17 Mar 2017
09 Mar 2017
30 Jan 2017
05 Jan 2017
publication
Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.
Read more14 Jul 2016
15 Dec 2015
14 Dec 2015
publication
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
Read more11 May 2015
02 Apr 2015
11 Dec 2014
publication
A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma
Read more19 Nov 2014
publication
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Read more05 Aug 2014
publication
Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Read more18 Jul 2014
04 May 2014
publication
Common polymorphic effectors of immunity against hepatitis B and C modulate susceptibility to infection and spontaneous clearance in a Moroccan population
Read more16 Apr 2014
publication
Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome
Read more26 Jul 2013
publication
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation
Read more02 Jul 2013
25 Mar 2013
22 Feb 2013
publication
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
Read more08 Oct 2012
publication
Insertion/deletion polymorphisms are convenient and reliable markers to assess chromosomal instability in human tumors
Read more17 Jun 2012
publication
Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma
Read more06 Apr 2012
26 Feb 2012
publication
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
Read more14 Oct 2011
publication
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
Read more25 Apr 2011
publication
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Read more02 Mar 2011
publication
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
Read more27 Jan 2011
publication
First multicenter study for risk factors for hepatocellular carcinoma development in North Africa
Read more14 Oct 2010
publication
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice
Read more27 May 2010
01 May 2010
22 Apr 2010
01 Jan 2010
publication
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
Read more15 Dec 2009
24 Sep 2009
10 Feb 2009
publication
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
Read more01 Feb 2009
16 Mar 2008
publication
Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure
Read more19 Feb 2008
publication
Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity
Read more03 Feb 2008
25 May 2007
20 Mar 2007
18 Mar 2007
05 Feb 2007
publication
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
Read more01 Feb 2007
publication
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer
Read more05 Jan 2007
17 Dec 2006
publication
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus
Read more02 May 2006
publication
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma
Read more01 Dec 2005
publication
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
Read more07 Sep 2005
publication
FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family
Read more01 Jul 2005
publication
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
Read more15 Dec 2004
publication
A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species
Read more18 Nov 2004
publication
HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF
Read more09 Sep 2004
publication
Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance
Read more01 Nov 2003
publication
Loss of parental-specific methylation at the IGF2 locus in human hepatocellular carcinoma
Read more18 Sep 2003
publication
Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification
Read more01 Sep 2003
20 Aug 2003
publication
Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci
Read more01 Apr 2003
publication
Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis
Read more01 Jan 2003
publication
Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma
Read more13 Sep 2002
publication
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha
Read more01 Jul 2002
01 Jun 2002
11 Jan 2002
29 Oct 2001
01 Aug 2001
publication
Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation
Read more01 May 2001
publication
Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification
Read more01 Jan 2001
01 Aug 2000
publication
Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
Read more01 May 2000
01 May 2000
01 Mar 2000
publication
Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey
Read more01 Feb 2000
publication
Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies
Read more11 Nov 1999
publication
Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas
Read more01 Jun 1999
publication
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption
Read more01 Jun 1999
20 May 1999
publication
Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma
Read more01 Dec 1998
publication
Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells
Read more23 Jun 1998
publication
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
Read more14 May 1998
publication
Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
Read more01 Mar 1998
publication
Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma
Read more01 Jan 1998
publication
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
Read more19 Aug 1997
publication
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia
Read more01 Aug 1997
publication
Molecular cloning of a new interferon-induced PML nuclear body-associated protein
Read more19 Jun 1997
01 Apr 1997
publication
The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice
Read more01 Jan 1997
publication
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
Read more01 Oct 1996
publication
A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus
Read more01 Jun 1996
publication
A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias
Read more01 Mar 1996
publication
Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia
Read more01 Oct 1995
publication
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies
Read more01 Sep 1995
publication
The acute promyelocytic leukaemia-associated PML gene is induced by interferon
Read more01 Aug 1995
publication
Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways
Read more01 Apr 1995
publication
PML nuclear bodies are general targets for inflammation and cell proliferation
Read more09 Jan 1994
publication
The PML-RAR gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells
Read more01 Jan 1994
publication
Retinoic acid regulates aberrant nuclear localization of PML-RAR in acute promyelocytic leukaemia cells
Read more15 Oct 1993
publication
The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1
Read more01 Jan 1993
publication
A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro
Read more15 Jun 1992
publication
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia
Read more23 Aug 1991
publication
The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
Read more01 Dec 1990
publication
The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias
Read more11 Oct 1990
publication
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
Read more01 Jun 1990
publication
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma
Read more11 Jan 1990
publication
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene
Read more01 Feb 1989
publication
Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes
Read more01 Oct 1988
publication
Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3
Read more28 Apr 1988
17 Dec 1987
publication
A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma
Read more03 Jul 1986
publication
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma
Read more10 Oct 1985
01 Sep 1984
publication
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat
Read more01 Mar 1984
publication
Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus
Read more01 May 1983
publication
Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5
Read more01 Aug 1982
publication
Presence and state of woodchuck hepatitis virus DNA in liver and serum of woodchucks: further analogies with human hepatitis B virus
Read more01 Jan 1982
publication
Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA
Read more01 Jun 1981
publication