Timeline

Anne Dejean
Head of Structure
18 Jul 2019
project

Deconstructing the role of SUMO on chromatin in cell identity and tissue repair (ERC-2018-AdG SUMiDENTITY)

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22 Oct 2018
publication

SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states

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13 Aug 2018
publication

Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden

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12 Dec 2017
publication

Shigella entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation

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06 Dec 2017
publication

Shigella entry unveals a calcium/calpain-dependent mechanism for inhibiting sumoylation

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17 Mar 2017
publication

Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

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09 Mar 2017
event

« Cancer cell of origin and tumor heterogeneity »

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30 Jan 2017
publication

SUMO and the robustness of cancer

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05 Jan 2017
publication

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.

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14 Jul 2016
publication

Protein SUMOylation Is Required for Regulatory T Cell Expansion and Function

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05 May 2016
publication

USP1 Regulates Cellular Senescence by Controlling Genomic Integrity

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15 Dec 2015
project

Molecular Epidemiology of Hepatocellular carcinoma

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14 Dec 2015
publication

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

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11 May 2015
team

Nuclear Organization and Oncogenesis

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02 Apr 2015
publication

TP53 R72P polymorphism modulates DNA methylation in hepatocellular carcinoma

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11 Dec 2014
publication

A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma

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19 Nov 2014
publication

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

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05 Aug 2014
publication

Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri

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18 Jul 2014
publication

Sumoylation of human argonaute 2 at lysine-402 regulates its stability

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04 May 2014
publication

Common polymorphic effectors of immunity against hepatitis B and C modulate susceptibility to infection and spontaneous clearance in a Moroccan population

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16 Apr 2014
publication

Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome

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26 Jul 2013
publication

Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation

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02 Jul 2013
publication

Somatic changes in primary liver cancer in Russia: a pilot study

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25 Mar 2013
publication

Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation

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22 Feb 2013
publication

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

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08 Oct 2012
publication

Insertion/deletion polymorphisms are convenient and reliable markers to assess chromosomal instability in human tumors

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17 Jun 2012
publication

Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma

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06 Apr 2012
publication

[A new player in PML-mediated cellular senescence: TBX2 gets into the loop]

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26 Feb 2012
publication

Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells

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14 Oct 2011
publication

Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

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25 Apr 2011
publication

p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

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02 Mar 2011
publication

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

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27 Jan 2011
publication

First multicenter study for risk factors for hepatocellular carcinoma development in North Africa

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14 Oct 2010
publication

Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice

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27 May 2010
publication

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

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01 May 2010
publication

Reprogramming of miRNA networks in cancer and leukemia

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22 Apr 2010
publication

Listeria monocytogenes impairs SUMOylation for efficient infection

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01 Jan 2010
publication

SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7

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15 Dec 2009
publication

miR-221 overexpression contributes to liver tumorigenesis

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24 Sep 2009
publication

PARP-1 transcriptional activity is regulated by sumoylation upon heat shock

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10 Feb 2009
publication

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

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01 Feb 2009
publication

[A review of cellular senescence: friend or foe of tumorigenesis?]

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16 Mar 2008
publication

Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure

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19 Feb 2008
publication

Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity

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03 Feb 2008
publication

Genotype determination in Moroccan hepatitis B chronic carriers

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25 May 2007
publication

Genomic stability prevails in North-African hepatocellular carcinomas

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20 Mar 2007
publication

SUMO is growing senescent

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18 Mar 2007
publication

C-terminal modifications regulate MDM2 dissociation and nuclear export of p53

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05 Feb 2007
publication

An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity

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01 Feb 2007
publication

Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer

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05 Jan 2007
publication

Role of SUMO in the dynamics of telomere maintenance in fission yeast

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17 Dec 2006
publication

Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus

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23 Jun 2006
publication

The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

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02 May 2006
publication

Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma

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01 Dec 2005
publication

The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice

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07 Sep 2005
publication

FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family

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01 Jul 2005
publication

Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein

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01 Feb 2005
publication

Human papillomavirus oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways

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15 Dec 2004
publication

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

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18 Nov 2004
publication

HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF

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09 Sep 2004
publication

Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance

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01 Nov 2003
publication

Loss of parental-specific methylation at the IGF2 locus in human hepatocellular carcinoma

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18 Sep 2003
publication

Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification

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01 Sep 2003
publication

Nuclear and unclear functions of SUMO

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20 Aug 2003
publication

Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci

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01 Apr 2003
publication

Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis

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01 Jan 2003
publication

Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma

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13 Sep 2002
publication

Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha

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01 Jul 2002
publication

Deconstructing PML-induced premature senescence

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01 Jun 2002
publication

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

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11 Jan 2002
publication

The nucleoporin RanBP2 has SUMO1 E3 ligase activity

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29 Oct 2001
publication

SUMO: of branched proteins and nuclear bodies

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01 Aug 2001
publication

Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation

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01 May 2001
publication

Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification

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01 Jan 2001
publication

Regulation of Pax3 transcriptional activity by SUMO-1-modified PML

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01 Aug 2000
publication

Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients

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01 May 2000
publication

Role of SUMO-1-modified PML in nuclear body formation

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01 May 2000
publication

c-Jun and p53 activity is modulated by SUMO-1 modification

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01 Mar 2000
publication

Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey

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01 Feb 2000
publication

Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies

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11 Nov 1999
publication

Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas

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01 Jun 1999
publication

Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption

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01 Jun 1999
publication

The PML nuclear bodies: actors or extras?

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20 May 1999
publication

Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma

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01 Dec 1998
publication

Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells

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23 Jun 1998
publication

Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

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14 May 1998
publication

Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein

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01 Mar 1998
publication

Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma

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01 Jan 1998
publication

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

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19 Aug 1997
publication

SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia

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01 Aug 1997
publication

Molecular cloning of a new interferon-induced PML nuclear body-associated protein

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19 Jun 1997
publication

Comprehensive allelotyping of human hepatocellular carcinoma

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01 Apr 1997
publication

The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice

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01 Jan 1997
publication

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

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01 Oct 1996
publication

A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus

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01 Jun 1996
publication

A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias

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01 Mar 1996
publication

Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia

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01 Oct 1995
publication

Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies

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01 Sep 1995
publication

The acute promyelocytic leukaemia-associated PML gene is induced by interferon

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01 Aug 1995
publication

Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways

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01 Apr 1995
publication

PML nuclear bodies are general targets for inflammation and cell proliferation

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09 Jan 1994
publication

The PML-RAR gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells

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01 Jan 1994
publication

Retinoic acid regulates aberrant nuclear localization of PML-RAR in acute promyelocytic leukaemia cells

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15 Oct 1993
publication

The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1

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01 Jan 1993
publication

A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro

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15 Jun 1992
publication

A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia

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23 Aug 1991
publication

The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

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01 Dec 1990
publication

The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias

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11 Oct 1990
publication

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus

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01 Jun 1990
publication

Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma

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11 Jan 1990
publication

Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene

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01 Feb 1989
publication

Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes

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01 Oct 1988
publication

Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3

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28 Apr 1988
publication

Identification of a second human retinoic acid receptor

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17 Dec 1987
publication

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

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03 Jul 1986
publication

Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma

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10 Oct 1985
publication

The hepatitis B virus

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01 Sep 1984
publication

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat

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01 Mar 1984
publication

Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus

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01 May 1983
publication

Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5

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01 Aug 1982
publication

Presence and state of woodchuck hepatitis virus DNA in liver and serum of woodchucks: further analogies with human hepatitis B virus

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01 Jan 1982
publication

Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA

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01 Jun 1981
publication

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases

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