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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Nature reviews. Cancer

SUMO and the robustness of cancer

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature reviews. Cancer - 30 Jan 2017

Seeler JS, Dejean A

Link to Pubmed [PMID] – 28134258

Nat. Rev. Cancer 2017 01;

Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed sumoylation, is an important mechanism in cellular responses to stress and one that appears to be upregulated in many cancers. Here, we examine the role of sumoylation in tumorigenesis as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.

https://www.ncbi.nlm.nih.gov/pubmed/28134258