Ligne de temps
Anne Dejean
Responsable de Structure
17 sept. 2023
publication
Generation of embryo-like structures from mouse embryonic stem cells treated with a chemical inhibitor of SUMOylation and cultured in microdroplets
Lire plus26 mai 2023
news
New publication – Transient suppression of SUMOylation in embryonic stem cells generates embryo like structures
Lire plus17 mai 2023
15 avr. 2023
publication
Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structures
Lire plus06 oct. 2021
project
Integrating the activities of SUMO in gene expression, inflammation and cancer (ERC-2011-AdG SUMOSTRESS)
Lire plus06 oct. 2021
01 sept. 2021
02 mars 2021
publication
Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry
Lire plus23 sept. 2020
publication
SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes.
Lire plus18 sept. 2020
publication
An unanticipated tumor-suppressive role of the SUMO pathway in the intestine unveiled by Ubc9 haploinsufficiency.
Lire plus15 sept. 2020
publication
Extensive SUMO Modification of Repressive Chromatin Factors Distinguishes Pluripotent from Somatic Cells.
Lire plus18 févr. 2020
publication
Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells
Lire plus18 juil. 2019
project
Deconstructing the role of SUMO on chromatin in cell identity and tissue repair (ERC-2018-AdG SUMiDENTITY)
Lire plus22 oct. 2018
publication
SUMO safeguards somatic and pluripotent cell identities by enforcing distinct chromatin states
Lire plus13 août 2018
publication
Early-onset liver cancer in South America associates with low hepatitis B virus DNA burden
Lire plus12 déc. 2017
publication
entry unveils a calcium/calpain-dependent mechanism for inhibiting sumoylation
Lire plus06 déc. 2017
publication
Shigella entry unveals a calcium/calpain-dependent mechanism for inhibiting sumoylation
Lire plus17 mars 2017
09 mars 2017
30 janv. 2017
05 janv. 2017
publication
Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes.
Lire plus14 juil. 2016
15 déc. 2015
14 déc. 2015
publication
Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing
Lire plus11 mai 2015
02 avr. 2015
11 déc. 2014
publication
A peculiar mutation spectrum emerging from young peruvian patients with hepatocellular carcinoma
Lire plus19 nov. 2014
publication
Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit
Lire plus05 août 2014
publication
Sumoylation controls host anti-bacterial response to the gut invasive pathogen Shigella flexneri
Lire plus18 juil. 2014
04 mai 2014
publication
Common polymorphic effectors of immunity against hepatitis B and C modulate susceptibility to infection and spontaneous clearance in a Moroccan population
Lire plus16 avr. 2014
publication
Mutation spectrum of hepatocellular carcinoma from eastern-European patients betrays the impact of a complex exposome
Lire plus26 juil. 2013
publication
Sumoylation at chromatin governs coordinated repression of a transcriptional program essential for cell growth and proliferation
Lire plus02 juil. 2013
25 mars 2013
22 févr. 2013
publication
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
Lire plus08 oct. 2012
publication
Insertion/deletion polymorphisms are convenient and reliable markers to assess chromosomal instability in human tumors
Lire plus17 juin 2012
publication
Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma
Lire plus06 avr. 2012
26 févr. 2012
publication
Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells
Lire plus14 oct. 2011
publication
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
Lire plus25 avr. 2011
publication
p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2
Lire plus02 mars 2011
publication
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
Lire plus27 janv. 2011
publication
First multicenter study for risk factors for hepatocellular carcinoma development in North Africa
Lire plus14 oct. 2010
publication
Sumoylation by Ubc9 regulates the stem cell compartment and structure and function of the intestinal epithelium in mice
Lire plus27 mai 2010
01 mai 2010
22 avr. 2010
01 janv. 2010
publication
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7
Lire plus15 déc. 2009
24 sept. 2009
10 févr. 2009
publication
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer
Lire plus01 févr. 2009
16 mars 2008
publication
Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure
Lire plus19 févr. 2008
publication
Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity
Lire plus03 févr. 2008
25 mai 2007
20 mars 2007
18 mars 2007
05 févr. 2007
publication
An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity
Lire plus01 févr. 2007
publication
Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer
Lire plus05 janv. 2007
17 déc. 2006
publication
Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus
Lire plus02 mai 2006
publication
Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma
Lire plus01 déc. 2005
publication
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
Lire plus07 sept. 2005
publication
FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family
Lire plus01 juil. 2005
publication
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
Lire plus15 déc. 2004
publication
A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species
Lire plus18 nov. 2004
publication
HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF
Lire plus09 sept. 2004
publication
Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance
Lire plus01 nov. 2003
publication
Loss of parental-specific methylation at the IGF2 locus in human hepatocellular carcinoma
Lire plus18 sept. 2003
publication
Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification
Lire plus01 sept. 2003
20 août 2003
publication
Homozygous deletions scanning in tumor cell lines detects previously unsuspected loci
Lire plus01 avr. 2003
publication
Homozygous deletion scanning in hepatobiliary tumor cell lines reveals alternative pathways for liver carcinogenesis
Lire plus01 janv. 2003
publication
Mutation analysis of novel human liver-related putative tumor suppressor gene in hepatocellular carcinoma
Lire plus13 sept. 2002
publication
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha
Lire plus01 juil. 2002
01 juin 2002
11 janv. 2002
29 oct. 2001
01 août 2001
publication
Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation
Lire plus01 mai 2001
publication
Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification
Lire plus01 janv. 2001
01 août 2000
publication
Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
Lire plus01 mai 2000
01 mai 2000
01 mars 2000
publication
Effect of TT virus infection on hepatocellular carcinoma development: results of a Euro-Asian survey
Lire plus01 févr. 2000
publication
Covalent modification of the transcriptional repressor tramtrack by the ubiquitin-related protein Smt3 in Drosophila flies
Lire plus11 nov. 1999
publication
Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas
Lire plus01 juin 1999
publication
Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption
Lire plus01 juin 1999
20 mai 1999
publication
Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma
Lire plus01 déc. 1998
publication
Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells
Lire plus23 juin 1998
publication
Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
Lire plus14 mai 1998
publication
Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein
Lire plus01 mars 1998
publication
Extensive analysis of duplicated-inverted hepatitis B virus integrations in human hepatocellular carcinoma
Lire plus01 janv. 1998
publication
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
Lire plus19 août 1997
publication
SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia
Lire plus01 août 1997
publication
Molecular cloning of a new interferon-induced PML nuclear body-associated protein
Lire plus19 juin 1997
01 avr. 1997
publication
The acute promyelocytic leukemia PML-RAR alpha protein induces hepatic preneoplastic and neoplastic lesions in transgenic mice
Lire plus01 janv. 1997
publication
Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
Lire plus01 oct. 1996
publication
A t(3;8) chromosomal translocation associated with hepatitis B virus intergration involves the carboxypeptidase N locus
Lire plus01 juin 1996
publication
A retrovirus carrying the promyelocyte-retinoic acid receptor PML-RARalpha fusion gene transforms haematopoietic progenitors in vitro and induces acute leukaemias
Lire plus01 mars 1996
publication
Retroviral vectors for the transduction of the PML-RARalpha fusion product of acute promyelocytic leukemia
Lire plus01 oct. 1995
publication
Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies
Lire plus01 sept. 1995
publication
The acute promyelocytic leukaemia-associated PML gene is induced by interferon
Lire plus01 août 1995
publication
Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways
Lire plus01 avr. 1995
publication
PML nuclear bodies are general targets for inflammation and cell proliferation
Lire plus09 janv. 1994
publication
The PML-RAR gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells
Lire plus01 janv. 1994
publication
Retinoic acid regulates aberrant nuclear localization of PML-RAR in acute promyelocytic leukaemia cells
Lire plus15 oct. 1993
publication
The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1
Lire plus01 janv. 1993
publication
A hepatitis B virus pre-S-retinoic acid receptor beta chimera transforms erythrocytic progenitor cells in vitro
Lire plus15 juin 1992
publication
A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia
Lire plus23 août 1991
publication
The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
Lire plus01 déc. 1990
publication
The retinoic acid receptor alpha gene is rearranged in retinoic acid-sensitive promyelocytic leukemias
Lire plus11 oct. 1990
publication
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
Lire plus01 juin 1990
publication
Hepatitis B virus as an insertional mutagene in a human hepatocellular carcinoma
Lire plus11 janv. 1990
publication
Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene
Lire plus01 févr. 1989
publication
Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes
Lire plus01 oct. 1988
publication
Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3
Lire plus28 avr. 1988
17 déc. 1987
publication
A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma
Lire plus03 juil. 1986
publication
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinoma
Lire plus10 oct. 1985
01 sept. 1984
publication
Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat
Lire plus01 mars 1984
publication
Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus
Lire plus01 mai 1983
publication
Characterization of integrated hepatitis B viral DNA cloned from a human hepatoma and the hepatoma-derived cell line PLC/PRF/5
Lire plus01 août 1982
publication
Presence and state of woodchuck hepatitis virus DNA in liver and serum of woodchucks: further analogies with human hepatitis B virus
Lire plus01 janv. 1982
publication
Organization and expression of hepatitis B sequences cloned from hepatocellular carcinoma tissue DNA
Lire plus01 juin 1981
publication