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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Current opinion in genetics & development

The PML nuclear bodies: actors or extras?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in genetics & development - 01 Jun 1999

Seeler JS, Dejean A

Link to Pubmed [PMID] – 10377280

Curr. Opin. Genet. Dev. 1999 Jun;9(3):362-7

The PML and SP100-containing nuclear bodies (NBs) represent the best-studied example of a defined nuclear substructure the integrity of which is compromised in certain human diseases, including leukemia, neurodegenerative disorders and viral infection. Although recent progress has underscored the unexpectedly broad involvement of NB constituents in the control of cell growth, gene regulation and apoptosis in both pathological and normal contexts, evidence for a specific physiological activity within the NBs remains scant, thus precluding a unifying hypothesis for NB function.

https://www.ncbi.nlm.nih.gov/pubmed/10377280