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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : The Journal of general virology

Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of the virus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of general virology - 01 Mar 1984

Dejean A, Lugassy C, Zafrani S, Tiollais P, Brechot C

Link to Pubmed [PMID] – 6699625

J. Gen. Virol. 1984 Mar;65 ( Pt 3):651-5

Using the Southern blot technique, we have analysed the presence and state of hepatitis B virus (HBV) DNA in non-hepatic tissue from two human HBV carriers. HBV DNA sequences were detected in the pancreas, kidney and skin, demonstrating HBV infection of these organs. Moreover, the restriction DNA patterns were consistent with the integration of these viral sequences into high molecular weight DNA. These results demonstrate that HBV infection is not restricted to the liver.