Link to Pubmed [PMID] – 14506472
Nat. Rev. Mol. Cell Biol. 2003 Sep;4(9):690-9
Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.