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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Journal of immunology (Baltimore, Md. : 1950)

Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of immunology (Baltimore, Md. : 1950) - 17 Mar 2017

Wang A, Ding X, Demarque M, Liu X, Pan D, Xin H, Zhong B, Wang X, Dejean A, Jin W, Dong C

Link to Pubmed [PMID] – 28314856

J. Immunol. 2017 05;198(9):3461-3470

SUMOylation is an important posttranslational modification that regulates protein function in diverse biological processes. However, its role in early T cell development has not been genetically studied. UBC9 is the only E2 enzyme for all SUMOylation. In this study, by selectively deleting gene in T cells, we have investigated the functional roles of SUMOylation in T cell development. Loss of results in a significant reduction of CD4 and CD8 single-positive lymphocytes in both thymus and periphery. -deficient cells exhibit defective late-stage maturation post the initial positive selection with increased apoptosis and impaired proliferation, among which attenuated IL-7 signaling was correlated with the decreased survival of -deficent CD8 single-positive cells. Furthermore, NFAT nuclear retention induced by TCR signals was regulated by SUMOylation during thymocytes development. Our study thus reveals a novel posttranslational mechanism underlying T cell development.

https://www.ncbi.nlm.nih.gov/pubmed/28314856