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© Jacob SEELER & Anne DEJEAN, Institut Pasteur
Immunostaining of PML nuclear bodies involved in acute promyelocytic leukemia
Publication : Cancer epidemiology

Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma

Team: Nuclear Organization and Oncogenesis
Member: Anne Dejean
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cancer epidemiology - 17 Jun 2012

Akil A, Ezzikouri S, El Feydi AE, Benazzouz M, Afifi R, Diagne AG, Benjouad A, Dejean A, Pineau P, Benjelloun S

Link to Pubmed [PMID] – 22709982

Cancer Epidemiol 2012 Oct;36(5):e300-5

Hepatocellular carcinoma (HCC) is a common cause of death by cancer worldwide. In Morocco, HCC is characterized by few mutations and a mild chromosome instability suggesting that epigenetic changes may represent the driving force of tumorigenesis in the region. Recently, three studies looked for an association between EP300 or PCAF polymorphisms and cancer but there is a conspicuous lack of data regarding these histone acetyltransferase (HAT) variants and HCC development. The aim of the current study was to assess the impact of the Ile997Val in EP300 and Asn386Ser in PCAF polymorphisms on the risk of HCC.