Our aim is to characterize stem cells and their daughters during embryonic and postnatal development of skeletal muscle to understand how this tissue is established, how it regenerates, and how aging in this tissue is defined.
We are examining the gene regulatory networks that regulate myogenic stem cell emergence, and relating this to how cell order is established in this lineage with particular focus on transcription factors and signaling pathways. We are also investigating how stem/progenitor cells self-renew, essentially via symmetric vs. asymmetric cell divisions, and how the stem cell niche is defined.
