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© Research
Publication : Frontiers in cell and developmental biology

Mechanics and regulation of cytokinetic abscission.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Frontiers in cell and developmental biology - 01 Jan 2022

Andrade V, Echard A,

Link to Pubmed [PMID] – 36506096

Link to DOI – 104661710.3389/fcell.2022.1046617

Front Cell Dev Biol 2022 ; 10(): 1046617

Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting the daughter cells and concludes cell division. In different animal cells, it is well established that the ESCRT-III machinery is responsible for the constriction and scission of the ICB. Here, we review the mechanical context of abscission. We first summarize the evidence that the ICB is initially under high tension and explain why, paradoxically, this can inhibit abscission in epithelial cells by impacting on ESCRT-III assembly. We next detail the different mechanisms that have been recently identified to release ICB tension and trigger abscission. Finally, we discuss whether traction-induced mechanical cell rupture could represent an ancient alternative mechanism of abscission and suggest future research avenues to further understand the role of mechanics in regulating abscission.

https://pubmed.ncbi.nlm.nih.gov/36506096