Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer
CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Endothelium disruption by toxin-induced transcellular tunnels
Crossing of the epithelium and endothelium barriers by pathogens and their toxins represents essential steps in pejorative evolution of infections. We have discovered that several exotoxins from S. aureus and C. botulinum disrupt epithelium and endothelium barriers by targeting […]
Detection and countermeasures against bacterial toxins
Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]
Inhibitors of bacterial NAD kinases
NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]
2022The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization., Gut Microbes ; 14(1): 2121577.
2017Listeriolysin S Is a Streptolysin S-Like Virulence Factor That Targets Exclusively Prokaryotic Cells In Vivo., mBio 2017 04; 8(2): .
2017Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection, mBio 8:e02179-16..