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2024High Content Screening Assay of Inhibitors of the Legionella pneumophila Histone Methyltransferase RomA in Infected Cells., Chembiochem 2024 Sep; (): e202400293.
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2024A toolbox for enzymatic modification of nucleic acids with photosensitizers for photodynamic therapy, RSC Chem. Biol. 2024, 5, 841-852.
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2024Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy, Nature Communications, 2024, 15 (1), pp.4175. ⟨10.1038/s41467-024-48269-2⟩.
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2024Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy, Nature Communications.
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2024Adenine, a key player in biology and medicinal chemistry , Comptes Rendus Chimie, Académie des Sciences .
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2024Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells, Nature communication.
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2024Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization., J Cell Biol 2024 Apr; 223(4): .
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2024Facilitated Synthetic Access to Boronic Acid-Modified Nucleoside Triphosphates and Compatibility with Enzymatic DNA Synthesis, Synlett 2024, 35, 677-683.
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2023DAXX safeguards heterochromatin formation in embryonic stem cells, J Cell Sci. 2023 Sep 1:jcs.261092. doi: 10.1242/jcs.261092. Epub ahead of print. PMID: 37655670..
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2023A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation, Nucleic Acids Res. 2023 Aug 31.
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2023Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors., ACS Infect Dis 2023 May; (): .
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2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
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2022Enzymatic Synthesis of Vancomycin-Modified DNA, Molecules 2022, 27, 8927.
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2022Identification of Chemical Probes Targeting MBD2., ACS Chem Biol 2022.
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2022DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness, https://biorxiv.org/cgi/content/short/2022.04.11.487909v1.
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2022A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1., RSC Chem Biol 2022 Apr; 3(4): 456-467.
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2022Quinazoline-based analog of adenine as an antidote against MLL-rearranged leukemia cells: synthesis, inhibition assays and docking studies., Future Med Chem 2022 04; 14(8): 557-570.
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2022A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chem. Biol., 2022, 3, 85-95.
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2021Direct Synthesis of Allyl Amines with 2-Nitrosulfonamide Derivatives via the Tsuji-Trost Reaction., ChemistryOpen 2021 12; 10(12): 1166-1169.
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2021Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation, mBio. 2021 Nov-Dec; 12(6): e02558-21.
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, RSC Chemical Biology.
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2021The methylome of Biomphalaria glabrata and other mollusks: enduring modification of epigenetic landscape and phenotypic traits by a new DNA methylation inhibitor., Epigenetics Chromatin 2021 10; 14(1): 48.
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2021A Comparative Study on the Efficiency of Two Mycobacterium avium subsp. paratuberculosis (MAP)-Derived Lipopeptides of L3P and L5P as Capture Antigens in an In-House Milk ELISA Test., Vaccines (Basel) 2021 Sep; 9(9): .
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2021A ruthenium-oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy, ChemRxiv 2021, 10.33774/chemrxiv-2021-5n9xv.
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2021Towards the sustainable discovery and development of new antibiotics, Nat Rev Chem. 2021 Aug 19:1-24.
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2021Synthesis and Biological Activity of a Cytostatic Inhibitor of MLLr Leukemia Targeting the DOT1L Protein, Molecules 2021, 26(17), 5300 .
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2021Characterization of a triad of genes in cyanophage S-2L sufficient to replace adenine by 2-aminoadenine in bacterial DNA., Nat Commun 2021 08; 12(1): 4710.
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2021Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites., J Med Chem 2021 07; 64(14): 10403-10417.
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2021A genome-wide knock-out screen for actors of epigenetic silencing reveals new regulators of germline genes and 2-cell like cell state, bioRxiv 2021.05.03.442415.
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2021Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest., Pharmaceutics 2021 Jan; 13(1): .
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2021Engineering Synthetic Lipopeptide Antigen for Specific Detection of Mycobacterium avium subsp. paratuberculosis Infection., Front Vet Sci 2021 ; 8(): 637841.
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2020Chapter 4 – Targeting DOT1L for mixed-lineage rearranged leukemia, Histone Modifications in Therapy, Translational Epigenetics 2020.
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2020Study of the Effect of Substituents of ortho-Phenylenediamines in the Opening of Lactones and Lactams for Access to Benzimidazol-2-yl Alkanols and Benzimidazol-2-yl Alkylamines., SynLett 2020 31.
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2020Bisubstrate-Type Chemical Probes Identify GRP94 as a Potential Target of Cytosine-Containing Adenosine Analogs., ACS Chem Biol 2020 04; 15(4): 952-961.
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2020Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation, Cancers (Basel) 2020 Feb;12(2).
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2020DNA Methylation Bisubstrate Inhibitors Are Fast-Acting Drugs Active against Artemisinin-Resistant Plasmodium falciparum Parasites., ACS Cent Sci 2020 Jan; 6(1): 16-21.
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2019The Many Faces of Epigenetics, Oxford, December 2017, Epigenetics 2019 Apr 17:1-9.
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2019Demethylation by low-dose 5-aza-2′-deoxycytidine impairs 3D melanoma invasion partially through miR-199a-3p expression revealing the role of this miR in melanoma, Clin Epigenetics 2019 Jan;11(1):9.
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2019Microtubule-Driven Stress Granule Dynamics Regulate Inhibitory Immune Checkpoint Expression in T Cells, Cell Rep 2019 Jan;26(1):94-107.e7.
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2019Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide, Chemistry 2019 Jan;.
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2018Natural Products and Chemical Biology Tools: Alternatives to Target Epigenetic Mechanisms in Cancers, Chem Rec 2018 Dec;18(12):1854-1876.
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2018Identification of novel quinazoline derivatives as potent antiplasmodial agents, Eur J Med Chem 2019 Jan;161:277-291.
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2018A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy, Mol. Cancer Ther. 2018 Sep;17(9):1881-1892.
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2018The DNMT3A R882H mutant displays altered flanking sequence preferences, Nucleic Acids Res. 2018 Apr;46(6):3130-3139.
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2018Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-β-lactamases., Bioorg Med Chem 2018 07; 26(11): 2928-2936.
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2018Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches, J. Comput. Aided Mol. Des. 2018 Mar;32(3):435-458.
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2017Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors, Future Med Chem 2017 09;9(13):1465-1481.
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2017Cell wall peptidolipids of Mycobacterium avium: from genetic prediction to exact structure of a nonribosomal peptide., Mol Microbiol 2017 Aug; 105(4): 525-539.
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2017Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer’s disease., MAbs 2017 ; 9(6): 1016-1027.
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2016DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies, Biochem. Pharmacol. 2017 04;129:1-13.
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2016Identification of epigenetic factors regulating the mesenchyme to epithelium transition by RNA interference screening in breast cancer cells, BMC Cancer 2016 08;16:700.
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2016Identification and optimization of hydrazone-gallate derivatives as specific inhibitors of DNA methyltransferase 3A, Future Med Chem 2016;8(4):373-80.
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2015Design and synthesis of new non nucleoside inhibitors of DNMT3A, Bioorg. Med. Chem. 2015 Sep;23(17):5946-53.
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2015Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2′-deoxycytidine in human leukemic KG1 cells, Oncotarget 2015 Jun;6(17):15265-82.
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2015Combined analysis of DNA methylation and cell cycle in cancer cells, Epigenetics 2015;10(1):82-91.
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2014New insights on the mechanism of quinoline-based DNA Methyltransferase inhibitors, J. Biol. Chem. 2015 Mar;290(10):6293-302.
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2014Cytisine-like alkaloids from Ormosia hosiei Hemsl. & E.H. Wilson, Phytochemistry 2014 Nov;107:97-101.
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2014Challenges in developing novel DNA methyltransferases inhibitors for cancer therapy, Future Med Chem 2014 Jul;6(11):1237-40.
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2014Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity, PLoS ONE 2014;9(5):e96941.
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2014Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation, ChemMedChem 2014 Mar;9(3):590-601.
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2014Synergistic chromatin repression of the tumor suppressor gene RARB in human prostate cancers, Epigenetics 2014 Apr;9(4):477-82.
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2014Selective non-nucleoside inhibitors of human DNA methyltransferases active in cancer including in cancer stem cells, J. Med. Chem. 2014 Feb;57(3):701-13.
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2014Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1, J. Med. Chem. 2014 Jan;57(2):421-34.
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2013Development of a universal radioactive DNA methyltransferase inhibition test for high-throughput screening and mechanistic studies, Nucleic Acids Res. 2013 Oct;41(19):e185.
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2013Dichapetalins from Dichapetalum species and their cytotoxic properties, Phytochemistry 2013 Oct;94:184-91.
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2012DNA methylation inhibitors in cancer: recent and future approaches, Biochimie 2012 Nov;94(11):2280-96.
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2011Sequence-specific base pair mimics are efficient topoisomerase IB inhibitors, Biochemistry 2012 Jan;51(1):43-51.
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2011Commercial reverse transcriptase as source of false-positive strand-specific RNA detection in human cells, Biochimie 2011 Oct;93(10):1731-7.
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2011C5-DNA methyltransferase inhibitors: from screening to effects on zebrafish embryo development, Chembiochem 2011 Jun;12(9):1337-45.
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2011Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme–drug–DNA complex, Biochemistry 2011 Jun;50(22):5058-66.
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2011Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts, PLoS ONE 2011 Apr;6(4):e18554.
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2010Introduction “DNA and chromosomes: Physical and biological approaches”, Biochimie 2010 Dec;92(12):v-vi.
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2010Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine, PLoS ONE 2010 Aug;5(8):e12388.
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2010Specific hypomethylated CpGs at the IGF2 locus act as an epigenetic biomarker for familial adenomatous polyposis colorectal cancer, Epigenomics 2010 Jun;2(3):365-75.
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2003Synthesis and antiproliferative activity of basic ethers of 1,2-dihydropyrrolo[1,2-a]indole, 6H-isoindolo[2,1-a]indole, and 6H-benz[5,6]isoindolo[2,1-a]indole, Oncol. Res. 2003;13(12):537-49.
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2000Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ions, Biochem. Biophys. Res. Commun. 2000 Apr;270(2):363-9.
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