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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.
Starting Date
01
Jan 2008
Ending Date
14
Jul 2037
Status
Ongoing
Members
3
Structures
1
Publications
11

About

Digestive tract of mammals is one of the most complex microbial ecosystems subject to both external and internal factors, through food consumption and interactions with intestinal cells.

We are developing and using several experimental models of intestinal colonization to study how the two antogonistic populations of bacteria and bacteriophages coexist in the intestinal flora. We are focusing on Escherichia coli, one of the best studied facultative anaerobic bacterial species of the human microflora, and several virulent bacteriophages infecting a large panel of E. coli strains. Looking at both short and long term interactions between bacteriophages and their hosts in different ecological settings led us to uncover the underevaluated complexity of these interactions. Studies to identify the molecular mechanisms behind these interactions and more broadly the role of bacteriophages on intestinal homeostasis are undergoing.

ecoli-phage.jpg
Luisa De Sordi won the Best Talk Prize during the Evergreen Phage Biology Conference held in Olympia (USA) from August 2nd to 7th, 2015.

Fundings

References