This is an example of transplanted human iPSC derived cells.
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Uwe Maskos is a native Bavarian. He studied Physics and Chemistry. A graduate of New College, Oxford, he carried out his doctoral work with Professor Sir Edwin M. Southern (Lasker 2005), inventor of the ‘Southern Blot’, pursuing a highly original project, creating what was then going to become the first ever ‘DNA chips’. Having finished his DPhil at an early age, he went on to work in Neurobiology, a discipline that had started to captivate his interest already for a while. In Ron McKay’s laboratory, working at the National Institutes of Health (NIH), he developed a method of intra-uterine transplantation of neural stem cells. This was subsequently used to study the integration of cells derived from knock-out (KO) animals, human stem cells, and from differentiated embryonic stem (ES) cells, that he was also able to derive de novo. He was tenured working with Professor Jean-Pierre Changeux developing novel tools to study the neuronal nicotinic acetylcholine receptor (nAChR) in vivo. He is heading a Research Unit at the Institut Pasteur. In 2010 he received the Prix Duquesne.
Publications
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2024Targeting high-affinity nicotinic receptors protects against the functional consequences of β-amyloid in mouse hippocampus., Mol Psychiatry 2024 Aug; (): .
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2024Serum autoantibodies against α7-nicotinic receptors in subgroups of patients with bipolar disorder or schizophrenia: clinical features and link with peripheral inflammation, Translational Psychiatry, 2024, 14 (1), pp.146. ⟨10.1038/s41398-024-02853-8⟩.
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2023An original potentiating mechanism revealed by the cryo-EM structures of the human α7 nicotinic receptor in complex with nanobodies., Nat Commun 2023 Sep; 14(1): 5964.
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2023Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor., Cell Mol Life Sci 2023 May; 80(6): 164.
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2023Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero., Cells 2023 Mar; 12(7): .
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2023Impact of the gut microbiome on nicotine’s motivational effects and glial cells in the ventral tegmental area in male mice., Neuropsychopharmacology 2023 Mar; (): .
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2023Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue., Front Cell Neurosci 2023 ; 17(): 1259712.
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2022[Nicotinic acetylcholine receptor and chronic obstructive pulmonary disease]., Med Sci (Paris) ; 38(8-9): 637-639.
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2022The Nicotinic Receptor Polymorphism rs16969968 Is Associated with Airway Remodeling and Inflammatory Dysregulation in COPD Patients., Cells 2022 Sep; 11(19): .
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2022Divergent Roles of α5 and β4 Nicotinic Receptor Subunits in Food Reward and Nicotine-induced Weight Loss in Male Mice., Endocrinology 2022 Jul; 163(7): .
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