Philippe J. Sansonetti, MS, MD, is a microbiologist, Professor at the Pasteur Institute and the Collège de France in Paris. He is the Director of the Inserm Unit 1202 and of the Institut Pasteur laboratory Molecular Microbial Pathogenesis.
Concepts émergents pour des maladies émergentes
Chaire de Microbiologie et Maladies Infectieuses, Année académique 2016-2017 Philippe SANSONETTI, Professeur Programme : cours-sansonetti-2016-20172
MITICA: Identifying the mechanisms of acquisition of a dysbiotic microbiota and pediatric environmental enteropathy in infants in the context of chronic malnutrition
Undernutrition contributes to more than 40% of the global child mortality rate. In 2014 stunting, which is the main manifestation of chronic undernutrition, affected 159 million children. Stunting entails long-term repercussions for the child, […]
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Private: Histoire évolutive du bacille de la dysenterie épidémique (Shigella dysenteriae de type 1)
L’agent de la dysenterie épidémique, la bactérie Shigella dysenteriae de type 1, a été isolé au Japon en 1897 par le Dr Kyoshi Shiga au cours d’une vaste épidémie de diarrhée sanglante ayant provoqué […]
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]
Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Pathogens and symbionts: War and Peace at mucosal surfaces and in intestinal crypts. My previous ERC-funded grant HOMEOEPITH intended to achieve a major transition from our “classical” research focus on deciphering the molecular cross-talks […]
Medical perspective, translational research
Boosting epithelial innate antimicrobial mechanisms. Recurrent enteric infections in children of low income countries, chronic inflammatory bowel diseases, myelosuppressive/immunosuppressive therapies, are – among others – clinical situations that require strong boosting of mucosal innate […]
Peace: towards a cellular microbiology of bacterial symbiosis
Metagenomic description of the whole gut microbiome was recently provided (22) and attempts are made to establish correlations between variations in microbiome composition and the occurrence of diseases. Beside this correlative approach, it is […]
War: Rupture, invasion and inflammatory destruction of the gut epithelial barrier by Shigella
Our Unit, over the years, has provided a unique and detailed analysis of how a pathogen subverts an epithelial barrier. Central to this process is a type III secretory system (TTSS) that delivers effectors […]
2020Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
2019Intracellular offspring released from SFB filaments are flagellated, Nat Microbiol 2020 Jan;5(1):34-39.
2019Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection, Cell Host Microbe 2019 10;26(4):565.
2019Mapping of Shigella flexneri’s tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs, Pathog Dis 2019 10;77(7).
2019Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection, Cell Host Microbe 2019 Sep;26(3):435-444.e4.
2019promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport, Proc. Natl. Acad. Sci. U.S.A. 2019 Jul;116(27):13582-13591.
2018MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker, Cell Chem Biol 2018 Apr;25(4):483-493.e9.
2017Colorectal cancer specific conditions promote gut colonization, Proc. Natl. Acad. Sci. U.S.A. 2018 01;115(2):E283-E291.
2017Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy, Cell Host Microbe 2017 Jun;21(6):769-776.e3.
2016Anoxia and glucose supplementation preserve neutrophil viability and function, Blood 2016 Aug;128(7):993-1002.
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