Philippe J. Sansonetti, MS, MD, is a microbiologist, Professor at the Pasteur Institute and the Collège de France in Paris. He is the Director of the Inserm Unit 786 and of the Institut Pasteur laboratory Molecular Microbial Pathogenesis.
“Salmonella diarrhea: growth, gene transfer and mutations to escape the host’s immune response” – Wolf-Dietrich Hardt
Concepts émergents pour des maladies émergentes
Chaire de Microbiologie et Maladies Infectieuses, Année académique 2016-2017 Philippe SANSONETTI, Professeur Programme : cours-sansonetti-2016-20172
The Afribiota project
Towards a better understanding and treatment of childhood malnutrition in the developing world Pediatric Environmental Enteropathy (PEE) and malnutrition are complex syndromes, reflecting a plethora of diverse environmental influences. To tackle this complexity, […]
LabEx IBEID – Integrative Biology of Emerging Infectious Diseases
Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart, is to develop a structure to anticipate and tackle emerging infectious diseases (EIDs). […]
MITICA: Identifying the mechanisms of acquisition of a dysbiotic microbiota and pediatric environmental enteropathy in infants in the context of chronic malnutrition
Undernutrition contributes to more than 40% of the global child mortality rate. In 2014 stunting, which is the main manifestation of chronic undernutrition, affected 159 million children. Stunting entails long-term repercussions for the child, […]
A synthetic carbohydrate-based conjugate vaccine ready for a clinical trial
Phylogenomics of Shiga’s epidemic dysentery bacillus (Shigella dysenteriae type 1)
The agent of epidemic dysentery, the bacterium Shigella dysenteriae type 1, was isolated in Japan in 1897 by Dr Kyoshi Shiga during a massive epidemic of bloody diarrhea that caused 20,000 deaths over a […]
Welcome to the club! Welcome to Microfluidics@Pasteur! Our goal is to serve as the major entry point to all the scientists on the campus (beginners and experts) interested in undertaking projects where microfluidics is involved. Our […]
Pathogens and symbionts: War and Peace at mucosal surfaces and in intestinal crypts. My previous ERC-funded grant HOMEOEPITH intended to achieve a major transition from our “classical” research focus on deciphering the molecular cross-talks […]
Medical perspective, translational research
Boosting epithelial innate antimicrobial mechanisms. Recurrent enteric infections in children of low income countries, chronic inflammatory bowel diseases, myelosuppressive/immunosuppressive therapies, are – among others – clinical situations that require strong boosting of mucosal innate […]
Peace: towards a cellular microbiology of bacterial symbiosis
Metagenomic description of the whole gut microbiome was recently provided (22) and attempts are made to establish correlations between variations in microbiome composition and the occurrence of diseases. Beside this correlative approach, it is […]
War: Rupture, invasion and inflammatory destruction of the gut epithelial barrier by Shigella
Our Unit, over the years, has provided a unique and detailed analysis of how a pathogen subverts an epithelial barrier. Central to this process is a type III secretory system (TTSS) that delivers effectors […]
2017Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy, Cell Host Microbe 2017 Jun;21(6):769-776.e3.
2016Anoxia and glucose supplementation preserve neutrophil viability and function, Blood 2016 Aug;128(7):993-1002.
2015Draft genomes of Shigella strains used by the STOPENTERICS consortium, Gut Pathog 2015;7:14.
2015Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA, MBio 2015;6(3):e02567-14.
2015Streptococcus gallolyticus Pil3 Pilus Is Required for Adhesion to Colonic Mucus and for Colonization of Mouse Distal Colon, J. Infect. Dis. 2015 Nov;212(10):1646-55.
2015Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling, J. Biol. Chem. 2015 Jul;290(27):16678-97.
2015Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp, PLoS ONE 2015;10(3):e0121785.
2015An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei, PLoS Pathog. 2015 Mar;11(3):e1004749.
2015Pathogen manipulation of B cells: the best defence is a good offence, Nat. Rev. Microbiol. 2015 Mar;13(3):173-84.
2015Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance, EMBO Mol Med 2015 Mar;7(3):259-74.
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