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About

Marc Lecuit, MD, PhD, is a microbiologist and an infectious diseases physician. He is the Director of the Biology of Infection Unit at the Institut Pasteur and Inserm (U1117) and of the Listeria National Reference Center and WHO Collaborating Center. He is a Professor at Université Paris Cite and Deputy Head of the Department of Infectious Diseases and Tropical Medicine at the Necker-Enfants Malades University Hospital. ML is a member of EMBO and of the Academia Europaea, a Fellow of the European Academy of Microbiology and ESCMID, and a Senior Member of the Institut Universitaire de France.

Transversal Projects

Array

The microbial communities that live with us, the microbiota, are now understood to be a key component of our being, playing roles in metabolism, immunity and behavior. More than a decade has elapsed since […]

Ageing & Longevity

According to the WHO, the global percentage of people aged of more than 60 years will double from 11 to 22% between 2000 and 2050. Nowadays most of the elderly die of non-transmissible diseases […]

Major Federating Program Microbes & Brain

Program general concept Can microbes influence the brain to maintain health or drive pathology? Will our understanding of the microbes and brain connection generate novel therapeutic approaches? The Major Federating Program Microbes & Brain […]

The Southeast Asia encephalitis project

  An integrative approach to understand and fight infectious encephalitis in children An encephalitis is an acute inflammation of the central nervous system associated with neurologic dysfunction. The most common etiologies are infections by […]

LabEx IBEID – Integrative Biology of Emerging Infectious Diseases

Presentation The aim of the Integrative Biology of Emerging Infectious Diseases (IBEID) project, coordinated by Professors Philippe Sansonetti and Pascale Cossart and currently coordinated by Carla Saleh and Philippe Bastin, is to develop a […]

Projects

Project
Ongoing
2 Members

ERC-CoG INVADIS

Marc Lecuit (PI)

An infection is defined by the deleterious consequences of the interactions between a pathogen and a host. Thus, studying the biology of infection reveals critical properties of hosts and pathogens, and is a way […]
Project
Completed
2 Members

ERC-StG MICROTRANS

Marc Lecuit (PI)

Infections remain a major cause of mortality in humans. New infections are emerging, and resistance to antimicrobial drugs is widespread and expanding. There is thus an urgent need to develop novel therapeutic strategies based on rationally-designed drugs […]
Project
Ongoing
16 Members

Pathogen discovery through clinical metagenomics

Marc Eloit (PI)

Our main objective is to increase the knowledge regarding the human virome during homeostasis and diseases. We mainly focus on: immunocompromised patients, where new pathogens and new associations between known pathogens and diseases at found at higher frequency than […]
Project
Ongoing
4 Members

ERC-PoC PRESERVE

Marc Lecuit (PI)

The success of organ transplantation depends on the lifelong use of immunosuppressive drugs to prevent rejection of the donor cells by the recipient’s immune system. These immunosuppressive drugs have several limitations, most notably major […]
Project
Ongoing
5 Members

Role of microglia in neurological sequelae of Listeria monocytogenes infection

Marc Lecuit (PI)

Infections of the central nervous system (CNS) are frequently severe, lethal or leading to long-term neurological sequelae. Neonates endure the highest rates of mortality and disabilities from these infections. The mechanisms responsible for the […]
Project
Ongoing
3 Members

Deciphering the age-dependent susceptibility to Listeria monocytogenes

Claire Maudet-Crépin (PI)

Aging comes with specific pathologies that result in dependency states and high hospitalization rates, resulting in very high social and economic burdens. Understanding age-related pathologies is therefore critically needed. Listeria monocytogenes is the etiological […]
Project
Ongoing
6 Members

Think tank: Mucosal Immunology

Gérard Eberl (PI)

The Think tank Mucosal Immunology gathers several research units form the departments of immunology, microbiology, cellular biology and epidemilogy and infection, as well as from the Institut Imagine (Necker) and Hôpital Paul Brousse. It […]
Project
Ongoing
3 Members

Microbial translocation across the intestinal epithelium (ANR, Organolist)

Olivier Disson (PI)

We use intestinal organoids, live imaging and molecular/cell biology approaches to study Listeria monocytogenes translocation across the intestinal epithelium.
Project
Ongoing
5 Members

Host responses to microbial intestinal invasion, impact on microbial dissemination

Marc Lecuit (PI)

We study the impact of the portal of entry of microbes in the intestine on host responses and microbial dissemination. To this end, we combine in vivo, ex vivo and in vitro systems, as well […]
Project
Ongoing
4 Members

Listeria monocytogenes invasion of the placenta

Marc Lecuit (PI)

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the placenta. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, cell biology, […]
Project
Ongoing
3 Members

Listeria monocytogenes invasion of the central nervous system

Marc Lecuit (PI)

We study the host and bacterial factors involved in Listeria monocytogenes invasion of the central nervous system. To this end, we combine in vivo, ex vivo and in vitro systems, as well as imaging, […]
Project
Ongoing
4 Members

Subversive pro- and anti-inflammation trade-offs promote infection by Listeria monocytogenes (Infect-ERA, PROANTILIS)

Marc Lecuit (PI)

Listeriosis is a leading cause of death from food-transmitted bacterial pathogens. It can cause infections in the blood stream and brain, and lead to abortion, neonatal infection and fetal death. The causative organism, Listeria […]
Project
Ongoing
15 Members

When Gut Bacteria Changes Brain Functions

Pierre-Marie Lledo (PI)

We are interested in deciphering the relationships that link gut microbiota with the immune system and the brain. So far, the mechanisms underlying these interplay, and most importantly their consequences, remain largely unknown. Therefore […]
Project
Ongoing
8 Members

Human and ruminant neurolisteriosis: a comparative study (Swiss National Science Foundation, Sinergia)

Marc Lecuit (PI)

Neurolisteriosis is a common and frequently fatal complication of Listeria monocytogenes infection in human and ruminants. It has a high impact on human and animal health, but only little is known about its pathogenesis. […]
Project
Ongoing
4 Members

LISTERIAGEN (ANR)

Caroline Charlier-Woerther (PI)

The LISTERIAGEN project aims to identify host genetic factors associated with susceptibility to listeriosis.
Project
Ongoing
4 Members

MONALISA: A Multicenter Observational National Analysis on Listeriosis and Listeria

Caroline Charlier-Woerther (PI)

MONALISA is a prospective national study on invasive listeriosis. It aims to identify risk and prognostic factors for invasive listeriosis and to dissect the clinical and biological features of each form of infection (septicemia, central nervous system […]
Project
Ongoing
4 Members

Chikungunya virus pathogenesis

Marc Lecuit (PI)

Structural and functional studies of Chikungunya virus entry into host cells Deciphering Chikungunya virus cell biology by high-throughput / high-content screening Chikungunya virus infection of fibroblasts Chikungunya virus and the central nervous system infection  
Project
Ongoing
5 Members

Enterovirus EV71 pathogenesis

Marc Lecuit (PI)

This project aims to study the pathogenesis of EV71-associated encephalitis. It combines in vitro and in vivo approaches.

CV

Marc LECUIT, MD, PhD

Education
2004  Ability to supervise research (HDR), Paris Descartes University, Paris-F
2002  MD, Paris Descartes University, Necker-Enfants Malades University Hospital, Paris-F 2001  PhD, Paris Diderot University, Institut Pasteur, Paris-F
1996  Master (DEA), Paris Diderot University, Institut Pasteur, Paris-F
1993  Bachelor (Maîtrise), Paris 12 University, Paris-F

Current positions
Since 2013  Head, Biology of Infection Unit, Institut Pasteur, Paris-F
Since 2013  Director, Inserm Unit 1117, Institut Pasteur, Paris-F
Since 2008  Head, National Reference Center & WHO Collaborating Center on Listeria, Institut Pasteur, Paris-F
Since 2006  Professor of Medicine, Université Paris Cité, Paris, France
Since 2006  Deputy Head, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-F

Past positions
2019-2023  Chair, Department of Cell Biology and Infection, Institut Pasteur, Paris-F
2008–2012  Group leader, Microbes and host barriers Group, Institut Pasteur, Paris-F
2006–2012  Group leader, Inserm avenir Group, Institut Pasteur, Paris-F
2003–2005  Chief Assistant, Division of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-F
2002–2003  Post-doctoral fellow (with Jeffrey I. Gordon), Washington University in St. Louis, MO, USA
1997–2001  PhD student (with Pascale Cossart), Paris Diderot University, Institut Pasteur, Paris-F
1991–2001  Medical Internship and Residency Program, Paris Hospitals, Assistance Publique-Hôpitaux de Paris

Fellowships and awards
2020  Prix Eloi Collery, Académie Nationale de Médecine
2020  Senior Member, Institut Universitaire de France
2019  Member of Academia Europaea
2017  Prix Duquesne
2017  EMBO Member
2017  ESCMID Fellow
2016  Grand Prix Robert Debré
2015  ERC Consolidator Grant
2010  Médaille Louis Pasteur, Académie des Sciences
2010  ERC Starting Independent Researcher Grant
2009  Fondation pour la recherche médicale “Equipe” award
2009  Ville de Paris “Equipe” award
2009  Grand Prix Jean Hamburger de la Ville de Paris
2008  Institut Pasteur “Groupe à 5 ans” award
2006  Inserm “Equipe avenir” award
2005  Franco-British Prize of the Académie des Sciences and the Royal Society
2004  European Society of Clinical Microbiology and Infectious Diseases Young Investigator Award
2003  Research Award of the College of Professors of Infectious Diseases and Tropical Medicine
2002  EMBO Long-Term fellowship
2002  Philippe Foundation fellowship
2001  Prix Jean Valade Fondation de France
2000  Gold Medal of the Residency Program (Médaille d’Or du Concours de Médecine de l’Internat)
1999  Research Prize in Nutrition CIDEF

Supervision of graduate students and postdoctoral fellows
Since 2006  13 Postdocs, 8 PhD, 7 Master Students, 8 Undergraduate Students

Teaching activities
Since 2008  Courses in Master 1 and 2, Paris Descartes University and Pierre and Marie Curie University
Since 2006  Teaching position, Infectious Diseases, Paris Descartes University Medical School
2004–2006  Courses in Infectious Diseases and Microbiology, Paris Descartes University Medical School
1998–2002  Course in Microbiology, Institut Pasteur, Paris-F
1993–1998  Courses for Interns in Infectious Diseases, Laennec Center, Paris-F

Organization of scientific meetings
ISOPOL XX International symposium on listeriosis, Toronto, Canada, 2019 Sep 24-27, scientific committee member
ISOPOL XIX International symposium on listeriosis, Paris, France, 2016 Jun 14-17, scientific committee member
Gordon Research Conference, CNS Infections, Hong Kong, China, 2015 Jun 14-15, scientific committee member
Chikungunya 2013 Conference, Langkawi, Malaysia, 2013 Oct 28-30, scientific committee member
European Congress in Clinical Microbiology & Infectious Diseases 2010, 2011, 2013, program committee member
Metchnikoff’s Legacy, Institut Pasteur, Paris, France, 2008 Apr 28-30, scientific committee member

Institutional responsibilities
Since 2014  Member, steering committee, Center for Translational Research, Institut Pasteur
Since 2014  Member, steering committee, Bio Paris Cité Doctoral School, Infectiology and Microbiology, Paris-F
Since 2013  Member, scientific advisory board, Institut de Microbiologie et des Maladies Infectieuses, Aviesan
2007–2008  Member, award committee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID)
2007–2011  Member, scientific affairs subcommittee, Eur. Soc. Clin. Microbiol. Infect. Dis. (ESCMID)
2007–2010  Member, steering committee, National prospective survey on encephalitis
Since 2006  Member, steering committee, National Reference Center for Hereditary Immunodeficiency
Since 2006  Member, scientific advisory board, Cochin-Pasteur Clinical Investigation Center in Vaccinology
Since 2004  Member, Necker–Pasteur Center for Infectious Diseases

Commissions of trust
Since 2006  Member, Faculty of 1000 Biology, Section Microbiology, Cellular Microbiology & Pathogenesis
Since 2014  Scientific Advisory Board, Ville de Paris awards and Emergence grants
Since 2013  Editorial board member: Virulence, Journal of Visualized Experiments, Microbial Pathogenesis
Since 2013  Advisory board member: F1000Research
Since 2008  Reviewer: Nature, Science, Nature Medicine, N Engl J Med, Lancet, PNAS, eLife, Cell Host Microbe, Lancet Infect Dis, PLOS Pathogens, Molecular Microbiology, Cellular Microbiology, Journal of Infectious Diseases, Emerging Infectious Diseases, Infection and Immunity, …
Since 2008  Regular review panel member:  ANR, Inserm, Institut Pasteur, ERC, PHRC

Membership of scientific societies
Since 2007  Member, European Society of Clinical Microbiology and Infectious Diseases
Since 2004  Member, American Society for Microbiology
Since 2004  Member, American Society for Cell Biology

Publications

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